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Cascales Lab

@cascaleslab.bsky.social

How to specifically select a protein from one side of the membrane and to transport it on the other side ? That's what we love to understand. #T6SS #T9SS Location: CNRS - Aix-Marseille Université, France https://www.cascaleslab.fr

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Jose Bengoechea@josebengoechea.bsky.social · last mo.

Recruiting a postdoc to join my lab at @lshtm.bsky.social to work in an MRC porgramme grant funded project to dissect the gut colonziation by Klebsiella. In vivo and in vitro models, and new approaches to identify Klebsiella factors involved. jobs.lshtm.ac.uk/vacancy.aspx...

Job Opportunity at LSHTM: Research Fellow

The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...

jobs.lshtm.ac.uk

Cascales Lab@cascaleslab.bsky.social · 2mo ago

Happy to share the last publication of @bobytaillefer.bsky.social, showing that #T6SS heterogeneity is an attenuation strategy to optimizes the trade-off between competitive killing and survival.

PLOS Biology@plosbiology.org · 2mo ago

The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45

Top: Representative confocal fields of the 3 types of TssC-GFP-TssK microcolonies (homogeneous ON, heterogeneous, homogeneous OFF). Scale bars, 10 μm. Bottom: Model for the role of T6SS phenotypic heterogeneity in EAEC. Top: The Psci1 promoter integrates Fur- and Dam-dependent regulation, generating ON (T6SS⁺, yellow) and OFF (T6SS⁻, blue) subpopulations at a reversible equilibrium. Bottom left: OFF (blue) cells, which do not express T6SS, do not kill competitors but avoid triggering such defences (1). Due to the absence of killing activity, OFF cells are unable to colonize the niche (2). Bottom centre: While ON (yellow) cells assemble and deploy functional T6SS (1) and kill susceptible competitors (2), they provoke retaliatory attacks from defensive T6SS⁺ species (gray) and are eliminated and fail to colonize the niche (3). Bottom right: Heterogeneous ON/OFF population (1) optimizes colonization by killing neighboring cells (2). While ON (yellow) cells are eliminated by counterattacks by defensive T6SS+ species (gray), OFF (blue) cells resist (3) and can ensure a continuous supply of ON cells (4-5) while limiting population-wide exposure to retaliation.
Jeunes microbiologistes de la SFM@jm-sfm.bsky.social · 2mo ago

Ce mois-ci, Marie nous présente 𝗹'𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗰𝗼𝘂𝗽 𝗱𝗲 ❤️ 𝗱𝘂 𝗥𝗲𝗝𝗠𝗶𝗙 : Vous êtes vous déjà demandé comment remporter la victoire dans une compétition inter-bactérienne ? 𝗣𝗮𝗶𝗹𝗹𝗮𝘁 𝗲𝘁 𝗮𝗹., oui ! Ils ont découvert la stratégie de 𝘍𝘭𝘢𝘷𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘫𝘰𝘩𝘯𝘴𝘰𝘯𝘪𝘢𝘦 pour éliminer ses concurrents ! urlr.me/yAHSbK

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Cascales Lab@cascaleslab.bsky.social · 3mo ago

T2SS ? T4SS ? CDI ? T6SS ? T7SS ? NO ! The T9SS is also involved in interbacterial competition !! Great work by Maelle Paillat @maellepllt.bsky.social under the supervision of Thierry Doan @thicoz.bsky.social Congratulations to both ! Glad to see this story out !

Maelle Paillat@maellepllt.bsky.social · 3mo ago

Very happy to see the second story from my PhD out in @currentbiology.bsky.social An exciting project where we explored the roles of secretion systems and gliding motility in predatory behavior in F. johnsoniae. www.cell.com/current-biol...

Erwan Gueguen@macerwan.bsky.social · 7mo ago

Nous recrutons un Maître ou une Maîtresse de conférences en bactériologie moléculaire pour notre équipe MTSB au laboratoire MAP à Lyon, France. Le poste combine recherche sur l'adaptation des bactéries phytopathogènes et enseignement en génétique microbienne. Notre team : sites.google.com/view/mtsb

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Cascales Lab@cascaleslab.bsky.social · 8mo ago

Happy to share the last work of @jmartinkus.bsky.social, led by @dukasju.bsky.social Immunity arrays associated with Rhs and CDI toxins and linked to a novel genetic element (XPC cassette) confer protection against competitors. @currentbiology.bsky.social Kudos !! www.cell.com/current-biol...

Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors

Martinkus et al. show that Photorhabdus and Xenorhabdus species encode arrays of immunity genes whose protein products neutralize toxins secreted by competitors. These arrays, often linked to Xer pass...

cell.com

Catalin Bunduc@catalinbunduc.bsky.social · 8mo ago

🚨PhD position alert🚨 🔬Cryo-EM? ✅ 🧫Membrane proteins? - we've got 165 TMs for you! ✅ Join me and the team👥 in beautiful Amsterdam🚴 to untangle the amazing mycobacterial protein secretion machinery! 📝Apply here: tinyurl.com/mmxnfpnw 📆Deadline: 23 January #PhDstudent #T7SS #cryoEM #newPI

Vacature — PhD candidate; Mechanism and assembly of type VII secretion system machineries

We are looking for an enthusiastic and motivated PhD candidate to join Dr. Catalin Bunduc’s team in the Molecular Microbiology Section of the Amsterdam Institute for Life and Environment (A-LIFE).

tinyurl.com

Cascales Lab@cascaleslab.bsky.social · 9mo ago

Happy to share the last paper form the lab: Specialized shuttle proteins recognize T9SS signals and target effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social www.nature.com/articles/s42...

Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae

Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...

nature.com

Séamus Holden 🔬🦠🧫@seamusholden.bsky.social · 10mo ago

PhD project available in my lab. Email me with CV if interested www.findaphd.com/phds/project... #microsky #bioimaging

Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick on FindAPhD.com

PhD Project - Using super-resolution microscopy to investigate the mechanistic principles of bacterial cell wall remodelling at University of Warwick, listed on FindAPhD.com

findaphd.com

Pierre Santucci @pierresantucci.bsky.social · 10mo ago

Extremely happy to share the fruit of a beautiful collaborative research study. France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺 Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇 doi.org/10.1101/2025...

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

doi.org

Cascales Lab@cascaleslab.bsky.social · 10mo ago

Happy to share our work on a T6SS effector with ADP ribose cyclase activity, published in JBC @asbmbjournals.bsky.social Great work of Julius Martinkus @jmartinkus.bsky.social and (always) great collaboration with @dukasju.bsky.social and @laurentterradot.bsky.social www.jbc.org/article/S002...

Widespread deployment of the human CD38 ADP-ribosyl cyclase fold in antibacterial and anti-eukaryotic polymorphic toxins

Bacterial polymorphic toxins are modular weapons that mediate inter-microbial competition and host interactions by delivering diverse cytotoxic domains through specialized secretion systems. Here, we ...

jbc.org

Cascales Lab@cascaleslab.bsky.social · last yr.

Le LISM (lism.imm.cnrs.fr) propose une mobilité en NOEMI pour travailler sur des assemblages de l'enveloppe bactérienne. Profil microbiologie, biologie moléculaire, avec une envie de faire de la biochimie, de la microscopie ou de la biologie cellulaire ! Rejoignez une unité dynamique !!

Welcome - LISM

The research topics of the LISM today remain centered on biological membranes and in particular membranes of Gram-negative bacteria. Since […]

lism.imm.cnrs.fr