The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃

Congrats @handekarahan.bsky.social & our team members! A potential new drug target for Alzheimer's disease. Targeting the APOE pathway more effectively. Might also enhance neuroprotective pathways, offering resilience against disease progression. alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Deletion of neuronal Idol ameliorates Alzheimer's disease–related pathologies via APOE receptors

INTRODUCTION Overexpression of the low-density lipoprotein receptor (LDLR) is known to decrease apolipoprotein E (APOE) levels and alleviate amyloid beta (Aβ) pathology. We hypothesized that inhibit...

alz-journals.onlinelibrary.wiley.com

"The plagiarizing students of today will turn into the data-forging professors of tomorrow. Perhaps they already have." Source: The Harvard Crimson search.app/QfaFd

Plagiarize or Perish | Opinion | The Harvard Crimson

One might argue that academic dishonesty occurs everywhere, not just at success-obsessed places like Harvard. However, the problem is not about whether Harvard’s misconduct is unique; the problem is t...

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J&J's $5B Alzheimer's hope fades as anti-tau antibody posdinemab flops in phase 2 www.fiercebiotech.com/biotech/jjs-...

J&J's $5B Alzheimer's hope fades as anti-tau antibody posdinemab flops in phase 2

Johnson & Johnson’s attempt to develop a $5 billion-a-year Alzheimer’s disease drug has been rocked by a phase 2 flop. | Johnson & Johnson’s attempt to develop a $5 billion-a-year Alzheimer’s disease ...

fiercebiotech.com

NIH funding "Consider investigator career stage and promote sustainability of the biomedical research workforce" "Promote broad distribution and geographic balance of funding, considering the total amount and type of NIH funding already available to each investigator" grants.nih.gov/grants-proce...

Frost lab paper alert! This study was led by Dr. Paul Ramirez, Lead Biostatistician for the Brown University Center for Alzheimer’s Disease Research: alz-journals.onlinelibrary.wiley.com/doi/epdf/10.... 1/9

Our new review is out today! 𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀 We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility. onlinelibrary.wiley.com/doi/10.1111/...

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks

Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...

onlinelibrary.wiley.com

"Years after Brigham-Harvard scandal, U.S. pours millions into tainted stem-cell field" www.reuters.com/investigates... A bit outdated news Fabricated data in most research fields Reminds me of the following article "Why Most Published Research Findings Are False" journals.plos.org/plosmedicine...

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes - Al‐Amin - 2025 - Alzheimer's & Dementia - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Apolipoprotein ε4 exacerbates white matter impairment in a mouse model of Aβ amyloidosis by decreasing actively myelinating oligodendrocytes

INTRODUCTION The ε4 allele of the apolipoprotein E (APOE) gene is a risk factor for the development of Alzheimer's disease (AD). APOE4 isoform is associated with increased white matter lesions in hu.....

alz-journals.onlinelibrary.wiley.com

A very expensive R21 grant paid off well 🤩

open.substack.com/pub/andrewms...

Aging doesn't exist

“Biological aging,” I fear, is the pseudo-scientific association of societal bias with murky biochemistry.

open.substack.com

Excited to share new work from the lab showing that loss of AD risk gene Ms4a4a promotes abeta clearance and protects against amyloid plaque accumulation in a mouse model 🧠🐭 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

An interesting behind story. From a random mutant MOUSE 🐁 model To a HUMAN disease! Of course, Mouse models can be useful for understanding peripheral immune in Humans too. www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

nobelprize.org

Sandro Da Mesquita@da-mesquita.bsky.social · 11mo ago

Immunology Rocks! Immune tolerance is crucial in health and disease, even when it comes to our brain! Congratulations to the new Nobel Laureates in Physiology or Medicine! 🤩😁🎉 www.nobelprize.org/prizes/medic...

The future of universities: A Nature special report share.google/CkHwmHHBIU1K...

The future of universities: A Nature special report

The world's universities are under intense pressure. Nature examines the threats they face and asks how the sector can and must adapt to survive.

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"But given the growing emphasis on funding in many quarters as the sine qua non of academic achievement, we may reach the point where faculty members' obituaries will read along the lines of, "Professor X didn't leave much of an intellectual legacy, but he/she sure brought in a lot of grant money""

"FlyBase’s now-uncertain future highlights just how interconnected and interdependent research efforts are and how the effects of funding cuts to one institution can ripple worldwide. More than 4,000 labs use FlyBase." share.google/vYzdfRwVpnHb...

Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly

This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.

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Nevertheless, these two brief papers in BBRC, although not viewed as potentially seminal in the months after their publication, turned out to provide both the factual and conceptual underpinnings for all subsequent research on β-amyloidosis in AD By Masters & Selkoe pubmed.ncbi.nlm.nih.gov/22675658/

🤩Additional funding for AD & ADRD Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research www.nia.nih.gov/about/budget...

Fiscal Year 2027 NIH Professional Judgment Budget for Alzheimer’s Disease and Related Dementias Research: Advancing Progress in Dementia Research

The budget proposal outlines the additional funding needed in FY27 to advance NIH-supported research toward achieving the goals outlined by the National Plan to Address Alzheimer’s Disease.

nia.nih.gov

Reproducibility and Best Practices in Cell Biology rupress.org/jcb/collecti...

🤯 Postmortem vs Living brain Due to the unavailability of brain tissue from living people, most such studies are performed using tissue from postmortem brain. "Expression levels differed significantly for nearly 80% of genes,"🤯 www.nature.com/articles/s41...

A study of gene expression in the living human brain - Molecular Psychiatry

Molecular Psychiatry - A study of gene expression in the living human brain

nature.com

"it’s hard for me to believe that damaging the greatest biomedical research system in the world is the way to solve any problems, let alone the problem of antisemitism."

Tal Nuriel, PhD@talnuriel.bsky.social · last yr.

A little hesitant to post this on here, as I wrote it specifically for the Jewish community in Detroit...but maybe it'll inspire other scientists to write articles in their hometown papers. www.thejewishnews.com/opinion/biom...

End the unchecked growth of publishing fees and the overreliance on unpaid peer review A proposed NIH policy to limit allowable publication costs is a good start — but more must be done Peer reviewers should be paid for their considerable labor | STAT share.google/YXf4iuUCa9Zp...

End the unchecked growth of publishing fees and the overreliance on unpaid peer review

High publishing costs and a crumbling peer review infrastructure are symptoms of deeper structural issues in research.

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NIH chief calls for immediate research review, dangling threat of project termination By Darren Incorvaia Aug 15, 2025 3:53pm www.fiercebiotech.com/research/nih...

NIH chief calls for immediate research review, dangling threat of project termination

Jayanta Bhattacharya, M.D., Ph.D., director of the National Institutes of Health (NIH), has called on the agency’s scientific leadership to immediately review all of their current and planned resea | ...

fiercebiotech.com

"hyperphosphorylated tau PREVENTS the age-related decline in whole-body metabolism by preserving glucose tolerance and mitigating shifts in fuel utilization (respiratory exchange ratio; RER),"

Shannon Macauley@macauleylab.bsky.social · last yr.

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance

😡 The amount of bureaucratic barriers being thrown up for me to host an URM student from an urban high school and pay her a small stipend so she can afford to take this opportunity is making me absolutely stabby. Barriers to participation in STEM are real and undiminished.

Top-down and bottom-up neuroscience: overcoming the clash of research cultures | Nature Reviews Neuroscience share.google/WVex5VystbkH...

Top-down and bottom-up neuroscience: overcoming the clash of research cultures - Nature Reviews Neuroscience

As scientists, we want solid answers, but we also want to answer questions that matter. Yet, the brain’s complexity forces trade-offs between these desiderata, bringing about two distinct research app...

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Highly recommend everyone take a look! I especially like "Transcriptomic reprogramming represents a promising strategy for treating complex diseases"😍 Title: Cell-type-directed network-correcting combination therapy for Alzheimer’s disease www.cell.com/cell/fulltex...

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease

A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

cell.com

More than a decade-old story, but it resonates again now. "NIA is in an exceptional predicament. In recent years, it has made big commitments to costly clinical trials and large group projects." www.nature.com/articles/468... The value of top-down big projects needs to be reevaluated, especially now

Funding crisis hits US ageing research - Nature

Shortfalls hamper scientists' efforts to address a predicted epidemic of age-related diseases.

nature.com

Better Together: ORCID and Other Researcher Identifiers scholarlykitchen.sspnet.org/2025/07/16/b...

Better Together: ORCID and Other Researcher Identifiers - The Scholarly Kitchen

This post is based on a recently-published white paper by Alice Meadows and Josh Brown of MoreBrains Cooperative, in which they discuss why ORCID iDs work best in combination with other researcher ide...

scholarlykitchen.sspnet.org

"It also calls on Duke’s highest paid administrators and athletic personnel — those making over $500,000 — to consider voluntary, temporary pay cuts to offset the costs of a reduced budget, as opposed to laying off staff." www.dukechronicle.com/article/2025...

American Association of University Professors calls on Duke to 'immediately halt' its employee buyout program

The statement, signed by AAUP president Todd Wolfson, alleges that Duke did not consult faculty and staff in decision-making prior to rolling out the VSIP and has not been transparent with its cost-cu...

dukechronicle.com