1/ Delighted to share our paper out today in Nature: ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer. We found the switch that lets differentiated cells rewind into stem cells — in gut repair, and in metastasis. 🧵 doi.org/10.1038/s415...

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer - Nature

The RNA-binding protein ZFP36L2 mediates stress-adaptive plasticity in intestinal regeneration and colorectal cancer metastasis.

doi.org

Excited for #AACR26! Come check out our latest work and say hello at this fantastic session on the impact of the systemic macroenvironment on cancer

Very excited to have been awarded a Cancer Grand Challenge grant as part of team REWIRE-CAN @cancergrand.bsky.social to develop new approaches to combat cancer #plasticity. Our goal: to see all #colorectalcancer patients become colorectal cancer survivors.

Memorial Sloan Kettering Cancer Center@mskcancercenter.bsky.social · 5mo ago

🎉 Congratulations to MSK physician-scientist @karunamdphd.bsky.social and colleagues, who are part of an international team awarded a Cancer Grand Challenges grant — a prestigious global award providing up to $25M over five years to tackle some of the toughest challenges in #cancerresearch.

In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...

Inferring cancer type-specific patterns of metastatic spread using Metient - Nature Methods

Metient is a statistical framework that infers patterns of metastatic spread and reconstructs cancer migration histories.

nature.com

Super proud of all our amazing postdocs and the brilliant ideas and energy you contribute!

MSKEducation@mskeducation.bsky.social · 11mo ago

Meet #MSKPostdoc @chris-cowley14.bsky.social in the @karunamdphd.bsky.social lab! Chris studies colitis-associated cancer, an aggressive form of colorectal cancer linked to IBD. Using patient-derived organoids, he is uncovering how inflammation drives cancer susceptibility. #NPAW2025 🇿🇦

Congratulations Ellie @elliebenitez.bsky.social @mskeducation.bsky.social Tri-I MD/PhD student on being awarded the NIH/NCI F30 award! #proudPI

Immigrant workers, on average, are earning 17.9% less than a country’s native population, according to a paper in Nature. Three-quarters of the pay gap between the two correspond to a lack of accessible high-paying jobs for immigrants. go.nature.com/4nYgb0a #econsky 🧪

Congratulations to our recent Ganesh lab alumni Ahmed Mahmoud, Emile de Vet @emiliedevet.bsky.social, Aileen Rodriguez, Xiang (Molly Han) @xianghan.bsky.social - we are so proud and wish you all the best for career success! @mskeducation.bsky.social @mskcancercenter.bsky.social

Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social‬ www.nature.com/articles/s41...

Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature

The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

nature.com

Ready for an amazing educational session on tumor dormancy @theaacr.bsky.social with Drs. Isacke and Ganesh.

Congratulations Manisha Raghavan on winning both science and service awards at the Gerstner Sloan Kettering Graduate School retreat! #proudPI @mskeducation.bsky.social @mskcancercenter.bsky.social

Looking forward to sharing our work and learning about GI oncology research @mdanderson.bsky.social this week!

#preprint alert! Excited to share a #biobank of patient-derived #appendix cancer models, including matched primary-metastasis pairs, with novel insights into mechanisms and drug targeting of #peritoneal #carcinomatosis. Led by our 1st PhD student Ahmed Mahmoud www.biorxiv.org/content/10.1...

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer

Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on a...

biorxiv.org

Some great news: incredibly proud of our Medical Oncology Fellow Jaeyop Lee MD, PhD, comentored by David Scheinberg, who just received the NoA for an NCI K99/R00 award!!! Stay tuned for his groundbreaking work on CRC immunotherapy

📣The Beatson International Cancer Conference #BICC2025 is returning on Tuesday 27th – Thursday 29th May 2025 at the impressive Glasgow Science Centre! Celebrating 30 years of events, join us for 3 days of inspiring talks, posters and networking focusing on Data Science www.beatsonconference.org

Thank you @trevorgraham.bsky.social and Freddie Whiting for this nice commentary on our recent paper on progressive plasticity in colorectal cancer metastasis

Trevor Graham@trevorgraham.bsky.social · 2y ago

Freddie Whiting in our group wrote this thoughtful commentary on @karunamdphd.bsky.social's recent paper that explored cell state changes and plasticity in colorectal cancer evolution. He concludes we need to better understand epigenetic control of plasticity. authors.elsevier.com/c/1kTSf5Sx5g...

Starting 2025 with gratitude for @damonrunyon.org and all those who support our quest to understand and develop more effective treatments for metastatic cancer.

Damon Runyon Cancer Research Foundation@damonrunyon.org · 2y ago

Metastasis accounts for most cancer deaths. A study from Damon Runyon alum @karunamdphd.bsky.social reveals why metastatic tumors are so much harder to treat than primary tumors—and how the process of metastasis may be curbed.

2/Discover how colorectal cancer evolves during metastasis. This study reveals metastases shifting from stem-like to fetal progenitor states, driving squamous & neuroendocrine traits linked to poor outcomes. @karunamdphd.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

Progressive plasticity during colorectal cancer metastasis - Nature

Colorectal cancer metastasis involves dramatic plasticity and loss of PROX1-mediated repression of non-intestinal lineages.

nature.com

Happy Nearly Holidays from the Ganesh lab!

Chris Cowley, PhD@chris-cowley14.bsky.social · 2y ago

Got some pretty cool science cookin in the Ganesh Lab! @mskcc.bsky.social @karunamdphd.bsky.social

Join us in Austin, TXm Feb 9-10 2025, for an Abcam-sponsored symposium on Cancer and Metabolism. -RJD events.abcam.com/event/cancer...

Congratulations #ObenaufLab on this amazing study of how MAPK-induced PGE2 secretion induces tumor immunosuppression. Impressive work!

Anna Obenauf@obenaufa.bsky.social · 2y ago

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo

First post on this platform - thank you Elena @natrevgastrohep.bsky.social for this nice highlight of our recent Nature paper 👇🏽 www.nature.com/articles/s41... rdcu.be/d02rZ

Getting in on the starter pack game for folks focusing on studying tumor-immune interactions during metastasis — DM/comment if you want to be added! go.bsky.app/GyZxUDH