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Chris McGinnis

@cmcginnis.bsky.social

Cancer immunology, metastasis, TME, single-cell genomics | Postdoc Satpathy Lab Stanford | PhD Gartner Lab UCSF

62 Posts736 Follower511 Folgt
Liana Lareau@lianafaye.bsky.social · 12mo ago

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

Protein language models reveal evolutionary constraints on synonymous codon choice

Evolution has shaped the genetic code, with subtle pressures leading to preferences for some synonymous codons over others. Codons are translated at different speeds by the ribosome, imposing constrai...

biorxiv.org

Chrystal Paulos@chrystalpaulos.bsky.social · last yr.

🧵1/ New in @Cancer_Cell: Our lab discovered that Th17 cells must team up with B cells to eliminate tumors, and prevent it from coming back. 🔗 Read: www.cell.com/cancer-cell/... 🧬This unexpected immune duo sparks tumor immunity. 🖼️Image: See schematic Th17/B cell antitumor action!

Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

Cole et al. report that adoptively transferred, tumor-specific Th17 cells engage host B cells and drive B cell proliferation and differentiation. These Th17 cells require B cells for sustained immunit...

cell.com

Juliane Winkler@jwinkler.bsky.social · last yr.

Genomics fellows - ever wondered what to do with histopathology (e.g. H&E slides)? 🔬➕🧬🟰🤩 I am super excited to have contributed with @evachrenkova.bsky.social to this amazing effort of @andre-rendeiro.com & @yimin-zheng.bsky.social for multimodal data integration: LazySlide!🧵👇

Andre Rendeiro@andre-rendeiro.com · last yr.

🔬 Whole slide histopathology images are a goldmine for tissue biology and diagnostics - but too often locked away in inaccessible formats or tools. In our new preprint, we introduce LazySlide: an open-source, modular, and interoperable framework. www.biorxiv.org/content/10.1...

James Gagnon@james-gagnon.bsky.social · last yr.

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals. For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq. www.biorxiv.org/content/10.1...

MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos

Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...

biorxiv.org

Jeremy Berg@jeremymberg.bsky.social · last yr.

Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn. I felt I had to interrupt to respond...

Mara Sherman@marasherman.bsky.social · last yr.

Congratulations to the brilliant Boire and Pe’er labs plus all authors for this seminal study of the unique tumor immunology of the leptomeninges! ✨

@danapeer.bsky.social · last yr.

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Parker Institute for Cancer Immunotherapy (PICI)@parkerici.bsky.social · last yr.

What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer. 🔗 www.cell.com/cancer-cell/...

Translation dysregulation in cancer as a source for targetable antigens

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasin...

cell.com

Cancer Cell@cp-cancercell.bsky.social · last yr.

Online Now: Translation dysregulation in cancer as a source for targetable antigens

Translation dysregulation in cancer as a source for targetable antigens

Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide MHC presentation, increasing both tumor immunogenicity and sensitivity to ICB therapy. TYW2 expression levels in patients with melanoma predict clinical outcomes, highlighting translation regulatory factors as immunotherapy targets.

dlvr.it

Yardena Samuels@yardenasamuels.bsky.social · last yr.

Thrilled to share our latest work in Cancer Cell! 🚨 Led by @chenweller, Osnat Bartok, with amazing collaborators @Chrismcginnis, @AnsumanSatpathy, Andreas Schlosser, @EytanRuppin & more, we reveal that impaired translation fidelity enhances anti-tumor immunity!🧵(1/7)

James Briscoe@jamesbriscoe.bsky.social · last yr.

Provocative but important commentary from Sui Huang & co Argues we need to change the paradigm of cancer origin from a somatic mutation theory to one grounded in gene regulatory networks & tissue organisation: a system level rather purely genetic mechanism journals.plos.org/plosbiology/...

The end of the genetic paradigm of cancer

Genome sequencing results and single-cell transcriptomics continue to produce findings that challenge the idea that cancer is purely a ‘genetic disease’. This Essay delves into cancer omics data that ...

journals.plos.org

@danapeer.bsky.social · last yr.

1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer

Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...

biorxiv.org