Katharina Melkonian

@katharinamel1.bsky.social

Biologist, Post-Doc at LRSV_Toulouse. PhD at mpipz_cologne. Interested in #evoMPMI #proteins #interactomics #Marchantia || Views are my own

How do transcription factors bind DNA strongly, and in a switch like manner, while remaining sequence specific? Our new paper on a canonical plant TF suggests the answer is a previously underappreciated assembly state: transcription factor nanoclusters. www.science.org/doi/10.1126/...

Nanoclustering of a plant transcription factor enables strong yet specific DNA binding

Transcription factor nanoclusters balance the DNA binding trade-off between weakly binding oligomers and nonspecific condensates.

science.org

If you want to learn a bit about our research in a different way!! ⬇️ Please. Do not comment the 'climbing the staircase' part 😅

Thomas Ott@ottlab.bsky.social · 2mo ago

A new documentary on scientific approaches to replace industrial nitrogen fertilizers is now online @artefr.bsky.social (only in DE/FR). Among them is our and @pierremarcdelaux.bsky.social's work @ensa-research.bsky.social further supported by @cibss.bsky.social. www.arte.tv/de/videos/11...

Bacterial immune proteins have repeatedly evolved to become parts of eukaryotic immunity. But how? Our new preprint uncovers a recent horizontal transfer event & shows how eukaryotes co-opted a toxic bacterial immune protein 🦠🧪🧵 1/

Microscopy image showing yeast cells expressing a fluorescently tagged version of the amoeba TirC protein. TirC forms filaments that span the yeast cells.