Janis Keck

@keckjanis.bsky.social

phd student in computational neuroscience, interested in geometric principles of biological & artificial learning ||

1/7 🧠 My journey into development begins with this work and question: how does the brain's spatial navigation system develop? We found that the neural networks for spatial navigation (tori and rings) are preconfigured and only later anchor gradually to the world with experience! 🧵

Edvard I Moser@edvardmoser.bsky.social · 7mo ago

Is spatial navigation innate 🧠? Using #NeuroPixels we show that the #torus 🍩 underlying the #GridCell map exists already on day 10 in rats — before pups open eyes and ears and before they start upright walking. 🧵1:4 👇 www.biorxiv.org/content/10.6...

Can whole-brain fMRI responses to naturalistic video stimuli be predicted using only transcripts? Last year, I gave a tutorial on exactly that. Since the response was very positive, I’ve now released both the tutorial notebook and the trained models publicly.

“Humans across multiple languages spontaneously associate the nonwords kiki & bouba with spiky & round shapes, respectively...We tested the bouba-kiki effect in baby chickens. Similar to humans, they spontaneously chose a spiky shape when hearing a kiki sound & a round shape when hearing a bouba.”😲🧪

Matching sounds to shapes: Evidence of the bouba-kiki effect in naïve baby chicks

Humans across multiple languages spontaneously associate the nonwords “kiki” and “bouba” with spiky and round shapes, respectively, a phenomenon named the bouba-kiki effect. To explore the origin of t...

science.org

The hippocampal map has its own attentional control signal! Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See 📹 in post 4/6 and preprint here 👉 www.biorxiv.org/content/10.6... 🧵(1/6)

Attention-like regulation of theta sweeps in the brain's spatial navigation circuit

Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion — without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)

biorxiv.org

New preprint! Have you ever wondered, what are these fuzzy simplicial sets, the theoretical framework behind e.g. UMAP? Here we show that you may simply see them as marginal distributions over simplicial sets. This provides a generative model for UMAP. (1/2) arxiv.org/abs/2512.03899

Probabilistic Foundations of Fuzzy Simplicial Sets for Nonlinear Dimensionality Reduction

Fuzzy simplicial sets have become an object of interest in dimensionality reduction and manifold learning, most prominently through their role in UMAP. However, their definition through tools from alg...

arxiv.org

New preprint from the lab and great work by Fei Wang. We show how subiculum trace vector cells can be modeled consistent with known effects in CA1. Traces are driven by a mismatch learning rule to keep associative memories in line with experience. www.biorxiv.org/content/10.1...

Dynamic updating of cognitive maps via traces of experience in the subiculum

In the classical view of hippocampal function, the subiculum is assigned the role as the output layer. In spatial paradigms, some subiculum neurons manifest as so-called boundary vector cells (BVCs), ...

biorxiv.org

Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology

Arousal as a universal embedding for spatiotemporal brain dynamics - Nature

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

nature.com

🚨We believe this is a major step forward in how we study hippocampus function in healthy humans. Using novel behavioral tasks, fMRI, RL & RNN modeling, and transcranial ultrasound stimulation (TUS), we demonstrate the causal role of hippocampus in relational structure learning.

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bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

Causal necessity of human hippocampus for structure-based inference in learning https://www.biorxiv.org/content/10.1101/2025.08.19.664920v1