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john sakon

@johnsakon.bsky.social

I’m a neuroscientist studying memory @ UCLA 🌌 *Were most of your stars out?* 🌌

385 Posts668 Follower405 Folgt
Amelia Eisch 🧪🧠👩‍🔬 🐁@eisch.bsky.social · 2w ago

New preprint from @sgrella.bsky.social team: silencing ventrolateral OFC (chemogenetically) blocks spatial memory-updating. Mice detect novelty fine but can’t use it to revise an existing memory. Deficit tracks w/ reduced engram reactivation in dentate gyrus. Looking forward to digging into this.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w ago

Chemogenetic Inhibition of the Ventrolateral Orbitofrontal Cortex Disrupts Prediction Error and Salience-Guided Memory-Updating at the Hippocampal Engram Level https://www.biorxiv.org/content/10.64898/2026.07.16.738971v1

ryan cooper@ryanlcooper.com · 2w ago

here’s my offer, The Atlantic magazine, I will read the next “reactionary pretends to give honest advice to Democrats” take if you let me write a piece where I, a DSA member, pretend to give honest advice to Republicans

The Atlantic@theatlantic.com · 2w ago

“Democrats appear slow to recognize that ideologues on the left are attempting a hostile takeover of the party,” James Kirchick writes. In looking for a way to reclaim control, he argues, they could find inspiration in British history:

Nicholas Grossman@nicholasgrossman.bsky.social · 3w ago

The US built the greatest talent magnet ever, attracting the smart, skilled, and striving. They’d come to study, then stay and build things here, or leave with positive impressions and fruitful connections. Helped make the US wealthy and powerful. Then America chose to throw it away. And for what?

Ben Allen@evodynamics.bsky.social · 3w ago

Congrats we just made it impossible to come here for a PhD www.bostonglobe.com/2026/07/16/m...

Naomi Klein@naomiaklein.bsky.social · last mo.

Everybody in the "climate space" (which means everyone on earth...) needs to understand these mind-blowing figures. Google's "total electricity consumption jumped from 31 terawatt hours (TWh) in 2024 to 43 TWh in 2025." In ONE year. The AI corporate arms race is eating the world.

Ketan Joshi@ketanjoshi.co · last mo.

NEW BLOG FOR YOU Google's energy consumption numbers in their new climate report are mind-blowing. 2 years ago they flipped from linear to exponential growth, and their climate impact is blowing out, too. A WILD testament to the obscene bloat and waste of GenAI: ketanjoshi.co/2026/07/01/g...

a chart showing google's rising energy consumption - huge, and rising faster than ever before
Ken Tremendous@kentremendous.bsky.social · last mo.

I am baffled that my campaign slogan for New York's 12th district, "Let's Close Our Eyes and Do Everything the Same Forever and Maybe Somehow Things Will Improve?" failed to rally Democratic voters. Some said "maybe lose the question mark" but I wasn't sure I could stand behind a flat statement.

Skye@simplyskye.bsky.social · 3mo ago

Mamdani: I cannot help but think of the words of our 40th president, Ronald Reagan. He famously said, “The nine most terrifying words in the English language are 'I'm from the govt & I'm here to help'" I think nine more terrifying words are actually, "I worked all day and can't feed my family"

john sakon@johnsakon.bsky.social · 3mo ago

Dems just aren’t prepared for the moment. And yet they blame whatever boogeyman they can come up with for why they’re not winning elections chasing imaginary flip voters. When they could be riling up a young, upset base eager to vote for a left populist agenda

Taniel@taniel.bsky.social · 3mo ago

Big news out of Utah: A justice announces she's resigning, shortly after GOP launched an investigation into her (for an alleged affair with a lawyer in a redistricting case). The gov will fill the vacancy — just like he's set to fill TWO others because the state GOP just expanded the court.

Ken Tremendous@kentremendous.bsky.social · 3mo ago

McConnell denied Garland a vote nine months out under the guise that there was an election soon and then jammed through Coney Barrett a week before Biden won. They have been flipping the bird to the concepts of norms and fairness for decades and the democrats have done jack shit to fight back.

Taniel@taniel.bsky.social · 3mo ago

The degree of political asymmetry on what judges/justices are up to these days, AND what politicians are doing to courts, is one of the most staggering aspects of our moment.

Erik Hane@erikhane.bsky.social · 3mo ago

there's simply no adequate political response to this that isn't based on fully destroying the people and party responsible for it

Ari Berman@ariberman.bsky.social · 3mo ago

Breaking: Tennessee Republicans pass new 9-0 gerrymander after SCOTUS destruction of Voting Rights Act eliminating state’s only majority-Black district & last Democratic seat. Splits Memphis, which is 63% Black, into 3 districts to disenfranchise Black voters. Quite literally a return to Jim Crow

Marcelo Mattar@marcelomattar.bsky.social · 4mo ago

New Annual Review with @nathanieldaw.bsky.social: “Planning in the Brain: It's Not What You Think It Is.” We argue that the brain's 'planning' machinery is mostly used for learning from simulated experience, and that thinking prospectively at decision time is just one special case of this process.

Planning in the Brain: It's Not What You Think It Is

The neuroscience of planning has long been analogized to search algorithms in artificial intelligence (AI), which simulate future actions to guide immediate choices. We argue that advances in both neu...

annualreviews.org

Melanie Tschiersch@mtschiersch.bsky.social · 2y ago

🚨Excited to share my first @biorxivpreprint.bsky.social🚨 with the amazing Smith lab, @jbarbosa.org and Albert Compte who made this work possible. We show that 🐒prefrontal hemispheres combine redundancy (for precision) & weak connections (for capacity) for supporting spatial working memory (WM). 1/🧵

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Redundant, weakly connected prefrontal hemispheres balance precision and capacity in spatial working memory https://www.biorxiv.org/content/10.1101/2025.01.15.633176v1

Ignacio Gallup-Diaz@igallupd.bsky.social · 4mo ago

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

Pancreatic cancer mRNA vaccine shows lasting results in an early trial

Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later.

nbcnews.com