Transient MYC Mimicking the Exercise Response Orchestrates Multifaceted Skeletal Muscle Adaptations

Despite decades of study, MYC's physiological role in adult tissues remains obscured by the models used to investigate it. Most work relies almost exclusively on chronic or constitutive MYC induction ...

biorxiv.org

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blu...

advanced.onlinelibrary.wiley.com

A Different Type of ‘Muscle Memory’

Repeated exercise, or wasting, can change the way key genes work.

theatlantic.com

Exercise to maintain and repair the ageing motoneurone-muscle axis

Has received a Professorship grant of DKK 20,000,000 from the Lundbeck Foundation.

lundbeckfonden.com

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle - Skeletal Muscle

Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to th...

tinyurl.com

biorxiv.org

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle

Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...

biorxiv.org

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice

Resident stem cells from aged planaria and murine skeletal muscle possess some inherent abilities to mitigate signs of aging after tissue regeneration.

onlinelibrary.wiley.com

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle

Abstract. Muscle stem cells, or satellite cells (SCs), decline in number throughout the lifespan and may become senescent in very old age. Whether and how

academic.oup.com

Prioritizing skeletal muscle health for successful aging

Kevin A. Murach talks us through prioritizing skeletal muscle health for successful aging, beginning with a primer on skeletal muscle aging

openaccessgovernment.org

Muscle memory theory: A critical evaluation

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physoc.onlinelibrary.wiley.com

Special Issue: Cardiac, skeletal muscle and neuromuscular plasticity in disuse and inactivity: The Journal of Physiology: Vol 603, No 13

<em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

Satellite cells choreograph an immune cell-fibrogenic cell circuit during mechanical loading in geriatric skeletal muscle

Abstract. Muscle stem cells, or satellite cells, decline in number throughout the lifespan and may become senescent in very old age. Whether and how remain

academic.oup.com

Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude | American Journal of Physiology-Cell Physiology | American Physiological Society

journals.physiology.org

microRNA-1 Regulates Metabolic Flexibility by Programming Adult Skeletal Muscle Pyruvate Metabolism

Metabolic flexibility refers to the ability of a tissue to adjust cellular fuel choice in response to conditional changes in metabolic demand and acti…

sciencedirect.com

Nature Aging

How long will we live? And how much of that time will comprise a healthy life? What is aging, and can we stop or even reverse the aging process? What is the ...

nature.com

Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice

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physoc.onlinelibrary.wiley.com

A history of omics discoveries reveals the correlates and mechanisms of loading-induced hypertrophy in adult skeletal muscle. 2024 CaMPS young investigator award invited review

journals.physiology.org

At the Nexus Between Epigenetics and Senescence: The Effects of Senolytic (BI01) Administration on DNA Methylation Clock Age and the Methylome in Aged and Regenerated Skeletal Muscle

Injury then recovery markedly rewires the DNA methylome in aged skeletal muscle.The addition of senolytics during muscle regeneration decelerates DNAmAGE more than regeneration alone as well as targe...

onlinelibrary.wiley.com

A History of Omics Discoveries Reveals the Correlates and Mechanisms of Loading-Induced Hypertrophy in Adult Skeletal Muscle | American Journal of Physiology-Cell Physiology | American Physiological S...

Since the early 2000s, omics approaches to study skeletal muscle hypertrophy consequent to loading (e.g. resistance exercise) have expanded dramatically. Beginning with genomics and transcriptomics, t...

journals.physiology.org

Biomarkers of aging: from molecules and surrogates to physiology and function | Physiological Reviews | American Physiological Society

Many countries face an unprecedented challenge in aging demographics. This has led to an exponential growth in research of aging, which, coupled to a massive financial influx of funding in the private and public sectors, has resulted in seminal insights into the underpinnings of this biological process. However, critical validation in humans have been hampered by the limited translatability of results obtained in model organisms, additionally confined by the need for extremely time-consuming clinical studies in the ostensible absence of robust biomarkers that would allow monitoring in shorter time frames. In the future, molecular parameters might hold great promise in this regard. In contrast, biomarkers centered on function, resilience and frailty are available at the present time, with proven predictive value for morbidity and mortality. In this review, the current knowledge of molecular and physiological aspects of human aging, potential anti-aging strategies, and the basis, evidence, and potential application of physiological biomarkers in human aging are discussed.

doi.org