This is now published in PNAS! And double-treat, we also made the cover :) www.pnas.org/doi/10.1073/...
Krishna Shrinivas@shrinivaslab.bsky.social · 11mo agoPreprint! Inspired by condensates that form on specific DNA, we ask: can we design multicomponent fluids to form distinct condensates on diff. surfaces? i.e. perform classification by condensation ⚛️ 💻 exploiting phase transitions beyond compartmentalization! arxiv.org/abs/2509.08100 (1/2)
Intrinsically disordered proteins (IDPs) flit between diverse shapes and interact in fuzzy ensembles whose collective properties shape function. Q: Can we rationally design emergent properties of IDPs? Our newest preprint takes a stab at this 🧵 biorxiv.org/content/10.6...
Ear Bending: Atlas of genes active in single cells of the developing inner ear 📷 @akankshi.bsky.social & @kkukreja.bsky.social et al @swinburnelab.bsky.social @harvardmed.bsky.social in @elife.bsky.social ➡️ bpod.org.uk/archive/2026...
🥁We are recruiting PhD students/Postdocs with strong proven background in developmental/molecular/cell biology & related areas, for various projects- check out our lab website👇🏼 We offer: competitive stipends, super equipped lab, fun international team! yanivelkoubylab.com
The Elkouby Lab - Cell and developmental biology of early oogenesis
The Elkouby Lab Illuminating unpredicted cellular machineries in gonad development, germ cell production, and reproduction A Journey to Before the Beginning of Life Exploring the Unknown Developing eg...
yanivelkoubylab.com
just finished reading katalin kariko @kkariko.bsky.social 's memoir. easily one of the most inspiring books I have read. whenever I feel down at work, face rejections or things feel unfair and hard, I can just hug the book to sleep and remind myself why we do science . . . .
Happy to share our latest in @natcomputsci.nature.com led by (amazing) Ryan Krueger + colab w M. Brenner! We introduce a framework to directly design intrinsically disordered proteins (IDPs) from physics-based simulations. 🧬 doi.org/10.1038/s435... 📰 www.mccormick.northwestern.edu/news/article...
Coupling and decoupling of the cell cycle from cell differentiation in development In this Spotlight, @kkukreja.bsky.social & Allon Klein discuss the dependence of animal cell differentiation on cell cycle, and how their decoupling facilitates development journals.biologists.com/dev/article-...
Our review on cell cycle – cell fate (de)coupling is out! doi.org/10.1242/dev.... Was a lot of fun writing this with Allon Klein, reading old papers(earliest from 1902), and speculating on why cell cycle progression is not necessary for differentiation across many many tissues and species. (1/3)
Coupling and decoupling of the cell cycle from cell differentiation in development
Summary: This Spotlight surveys investigations of the dependence of cellular differentiation on the cell cycle in animals. Strict dependence is uncommon. The decoupling of the cell cycle and different...
doi.org
📢 @shrinivaslab.bsky.social and colleagues introduce a method for designing unstructured proteins with tunable properties. www.nature.com/articles/s43... 🖥️ 🧬 🔓 rdcu.be/eJSuV
Generalized design of sequence–ensemble–function relationships for intrinsically disordered proteins - Nature Computational Science
The authors introduce a method that combines physics and machine learning to design dynamic unstructured proteins with tunable ensemble properties like size, shape, sensing and binding.
nature.com
Preprint! Inspired by condensates that form on specific DNA, we ask: can we design multicomponent fluids to form distinct condensates on diff. surfaces? i.e. perform classification by condensation ⚛️ 💻 exploiting phase transitions beyond compartmentalization! arxiv.org/abs/2509.08100 (1/2)
arXiv physics.bio-ph Biological Physics@physicsbioph-bot.bsky.social · 11mo agoAidan Zentner, Ethan V. Halingstad, Cameron Chalk, Michael P. Brenner, Arvind Murugan, Erik Winfree, Krishna Shrinivas: Information processing driven by multicomponent surface condensates https://arxiv.org/abs/2509.08100 https://arxiv.org/pdf/2509.08100 https://arxiv.org/html/2509.08100
New in @pnas.org with @gladfelterlab.bsky.social @sneadlab.bsky.social ! 📢 Cells use condensates (dynamic compartments without membranes) to organize key reactions. Some condensates have core & shell layers… but how do such layers form? 🤔 👉 pnas.org/doi/10.1073/pnas.2504778122 (1/6)
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications shorturl.at/2LHbw
Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h www.cell.com/cell-systems...
Loved this! Using devbio to engineer embryo models with notochord – neat and cool study. Lot of careful characterization of the embryo model.
James Briscoe@jamesbriscoe.bsky.social · 2y agoOur latest: how to generate the notochord "Timely TGFβ signalling inhibition induces notochord" A thread: www.nature.com/articles/s41...
My first post on bluesky!! Excited to see my PhD work featured on the cover of NCB @naturecellbiology.bsky.social December issue! This image shows a gorgeous #zebrafish embryo undergoing cell division (the green cells with condensed chromatin)—a fundamental process we study in development. 🧵1/2
Really liked reading this interview with @karalmckinley.bsky.social , so frank and honest! My favorite part "I think it's easy to get caught up in saying what we think is ‘the right thing’ to succeed, so much so that we can lose sight of what we are truly passionate about".
Development@dev-journal.bsky.social · 2y agoTransitions in development– an interview with Kara McKinley Here, @karalmckinley.bsky.social talks about her transition to becoming a PI, her insights on navigating the tenure-track market in biology and her dedication to promoting gender diversity within academia https://doi.org/10.1242/dev.204456
🔊 We are recruiting PhD students and Postdocs! We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology. 1/5
🥂Congratulations to Klein & co for their new study in our journal (@naturecellbiology.bsky.social) showing that blocking cell division does not affect major cell type differentiation during development, but it does decelerate differentiation of particular cell types. rdcu.be/d0Ry3
Cell state transitions are decoupled from cell division during early embryo development
Nature Cell Biology - Kukreja et al. show that blocking cell division in zebrafish does not affect differentiation of major cell types during gastrulation and segmentation, but it does decelerate...
rdcu.be
