James Kosmopoulos

@kosmopoulos.bsky.social

Fourth-year microbiology PhD candidate in the Anantharaman Lab at UW-Madison | Developing bioinformatics tools and resources for #viromics & exploring viral community ecology in soils | he/him

Last week I had the pleasure of presenting my thesis work on developing bioinformatics tools and databases for viral gene discovery and classification at the Midwest Microbiome Symposium, hosted at my alma mater, UIUC. It was great to see what microbiome scientists across the Midwest are working on!

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Check out this microbial ecology themed card game! I’ve been a fan of Ecologies for several years, so I was very excited to hear about their latest expansion. I think it would benefit from including more viruses… but I’m biased and still very impressed!

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🏰 Debate the frontiers of soil virology in a 13th-century French château. A few places just opened up! Join an international community of soil virus researchers for: 🎤 Keynotes from leading voices 💬 Roundtables on the field's biggest questions 🤝 Rare connections 👇 Register now

ISVC2026

We are excited to announce and provide RSVP details for the next International Soil Virus Conference that will be held in Saint Loup Lamairé, France on June 16 – 18, 2026. The aim of the conference…

soilmicrobes.fr

Lots of people have reached out asking how they can support us after the devastating fire in the MSL building, the heart of @cmarinescience.bsky.social Here’s one way, a GoFundMe organized by our graduate students - gofund.me/4373c6ff3. Please share widely, and thanks for helping our community!

Donate to USF Marine Science: Fire Recovery Support, organized by Bella Iannotta

On Saturday, May 2nd the University of South Florida Marine Science Lab (MSL)… Bella Iannotta needs your support for USF Marine Science: Fire Recovery Support

gofund.me

Protein–protein interactions (PPIs) are key to discovering and interpreting new biological functions. We’re excited to introduce 𝑭𝒍𝒂𝒔𝒉𝑷𝑷𝑰: a new application of gLM2 that uses genomic language modeling to predict proteome-wide PPIs in microbial genomes in minutes.

🚨vConTACT3 now in Nature Biotechnology: - >95% agreement with ICTV for known viruses - Classifies both prokaryotic and eukaryotic viruses - Extends beyond genus → subfamily, family & order - Systematically assigns taxonomy to tens of thousands of previously unclassified viruses

So happy this is finally out! We reconstructed the 1st large-scale spatiotemporal dataset of 600+ MAGs from San Francisco Bay and show they have functional redundancy in key N and S pathways. These functions may better recover from disturbance in this highly urban estuary 💧

Metabolic capacity is maintained despite shifts in microbial diversity in estuary sediments

Abstract. Estuaries are highly productive ecosystems where microbial communities drive nutrient and carbon cycling, supporting complex food webs. With inte

academic.oup.com

Soil viruses are important regulators of ecosystem function, but what are their roles in environments that face long-term degradation and restoration? In our paper published today in Nature Micro, we asked how soil viruses influence peatland recovery, and vice versa. www.nature.com/articles/s41...

Ecosystem health shapes viral ecology in peatland soils - Nature Microbiology

Metagenomics shows that viral diversity and community structure are shaped by geography and ecosystem health status, positioning viruses as unexpected players in peatland restoration.

nature.com

🦠🧪🧬🚨 New paper and database alert: the new IMG/VR release is now MetaVR ! We have a new website - meta-virome.org - with quick search capabilities for the >24M viruses, >12M vOTUs, and >42M protein clusters (including >790k with predicted structures !). academic.oup.com/nar/advance-...

Meta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomes

Abstract. Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is st

academic.oup.com

🚨vConTACT3 preprint live!🚨(Peer Review soon...!) vConTACT3 delivers a unified, scalable, and transparent framework for genome-based virus taxonomy — helping translate big viral data into systematic classification. 🔗 Read the preprint: doi.org/10.1101/2025... Improvements details below 👇

Scalable and systematic hierarchical virus taxonomy with vConTACT3

Viruses are key players in diverse ecosystems, but studying their impacts is technically and taxonomically challenging. Taxonomic complexities derive from undersampling, diverse DNA and RNA genomes wi...

doi.org

📢 Funded PhD opportunities for UK candidates in beautiful Edinburgh. Get in touch if you're interested in a PhD on understanding the mechanisms of soil carbon cycling and the role of microbes. We work in different ecosystems: peatlands, forests and agricultural soils. Please repost/spread the word.

Poster showing the following text: PhD in microbial mechanisms of soil carbon cycling. Soil microbes shape the global carbon cycle in life and death. We study the effect of aboveground land management on belowground soil carbon cycling processes. We aim create a scalable understanding of microbial processes from single cells to populations to communities to ecosystems. Pictures with text: peatland restoration, sustainable agriculture and woodland regeneration.

This past year, my dad was diagnosed with Parkinson's disease. On October 5th, our family will walk together as Team Kosmo at Moving Day Chicago to celebrate his strength and support everyone living with Parkinson's.

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New review paper on metabolic handoffs in microbiomes led by PhD student Katie Klier. We define major types of metabolic handoffs, examine their drivers and benefits, & describe their importance in different complex microbial systems and environments. www.sciencedirect.com/science/arti...

An updated view of metabolic handoffs in microbiomes

From the human gut to the deep ocean, diverse microbial communities underpin essential ecosystem processes. Limited understanding of the dynamics and …

sciencedirect.com