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Kosuke Takada

@kosuke-takada.bsky.social

Virologist in Eddie’s group @ USYD | Virology | Evolution

5 Posts43 Follower26 Folgt
ASM@asm.org · 6mo ago

In a guinea pig model, H5N1 replicated in the nose, trachea and lungs when delivered intranasally, by aerosol or by transmission. In contrast, H3N2 stayed mostly in the nose, suggesting mode of exposure modulates within-host spatial dynamics. #JVirology: asm.social/2PE

Barcode diversity is maintained in the URT but declines with increased distance from and branching of the main airways.
Kosuke Takada@kosuke-takada.bsky.social · 10mo ago

We’ve identified a highly divergent betacoronavirus from South American bat that encodes a functional furin cleavage site. Another fascinating reminder of how diverse coronavirus evolution is in wildlife reservoirs. #Virology #VirusEvolution #Bats #Coronavirus www.biorxiv.org/content/10.1...

A divergent betacoronavirus with a functional furin cleavage site in South American bats

Bats are natural reservoirs for a wide range of RNA viruses. Members of the genus Betacoronavirus, including Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) and Middle East Respiratory Syndrome...

biorxiv.org

Jon Mifsud@jonathonmifsud.bsky.social · 12mo ago

There’s been a bunch of new approaches looking at deep viral evolutionary history. We’ve put together a mini review highlighting some recent advancements in structural phylogenetics and time-dependent rate models and what they could do for the field 🦠 🔗 journals.asm.org/doi/full/10....

Recent advances in the inference of deep viral evolutionary history | Journal of Virology

Phylogenetic studies examining the origins, emergence, and spread of viruses have arguably been one of the most active and successful areas of evolutionary biology and form the bedrock of the flourishing field of genomic epidemiology. This, in part, reflects the ability of viruses, particularly those with RNA genomes, to evolve at rates much greater than their cellular counterparts (1). The rapid rate at which viruses evolve and accumulate mutations enables evolutionary signals to be identified through comparative genomics at short timescales relevant for outbreak investigation and response. The integration of phylogenetics and epidemiology, known as phylodynamics, has become a vital tool in response to numerous viral outbreaks, epidemics, and pandemics, including Ebola (2), Zika (3), and, more recently, COVID-19 (4) and mpox (5).

journals.asm.org