Jon Mifsud
@jonathonmifsud.bsky.social
Postdoc @ KU Leuven | Virus evolution 🧬👨💻
Get excited :) PhyloSpec is coming! A shared standard + modelling language for phylogenetic models. Write a model once, run it across engines like BEAST X, BEAST 2.8 & RevBayes. Easy and reproducible. Built by @tochsner.bsky.social & collaborators (ETH Zürich, Auckland, LMU). phylospec.com
PhyloSpec
A standardized way to describe phylogenetic model components, common assumptions, and best practices in the field of phylogenetics.
phylospec.com
🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st
Very excited to share our paper (and first for my PhD) on RdRpCATCH in NAR Genomics and Bioinformatics! doi.org/10.1093/narg... Co-authors: @urineri.bsky.social, @ingrida.bsky.social, Justine Charon, @sho1.bsky.social, @xinhou.bsky.social, Dick de Ridder, Mark P. Zwart, and @annecmg.bsky.social
RdRpCATCH: a unified resource for RNA virus discovery using viral RNA-dependent RNA polymerase profile Hidden Markov models
Abstract. Recent advances in large-scale sequence mining have expanded our knowledge of RNA virus diversity. Most genome mining approaches for detecting RN
doi.org
Inaugural post! We are a brand new lab @pasteur.fr studying how pathogen antigens evolve and how we can exploit these proteins' evolution to make better vaccines! Read a few words from the currently sole member of the lab @spyroslytras.bsky.social below! 😁 www.pasteur.fr/en/research-...
Predicting viral evolution with AI
Spyros Lytras is one of four young scientists selected in 2025 to lead new research groups at the Institut Pasteur. He has headed the “Antigen Evolution & Design laboratory” 5-year Group (G5) since Ju...
pasteur.fr
Please share 🚨 We have a postdoc position open on avian influenza virus tracking and genomics across natural to develop an early-warning system to protect human and animal health hrwebapp.qub.ac.uk/tlive_webrec...
Job profile
hrwebapp.qub.ac.uk
Until Friday, Australia was the only continent free from HPAI H5N1. Sadly, this is not the case - a 2344b confirmation in a Brown Skua, and a suspected case in a Northern Giant Petrel which turned up in WA. 👉 www.abc.net.au/news/2026-06... (1/x)
Super stoked to share that our Opinion article is now online at @cp-trendsgenetics.bsky.social!!! With "our" I mean: @teuneverts.bsky.social, @sdellicour.bsky.social and myself!! Here is a link to our piece: authors.elsevier.com/a/1nFgD_3rsx...
authors.elsevier.com
New work: Our earlier work showed that Foldseek characters could be adapted for phylogenetic alignment, treating each character as an evolutionary state. That part holds but there's a hidden assumption baked in that needed unpacking. So lets do that.🧵 #StructuralPhylogenetics #Evolution #Protein
New feature for PearTree - root-to-tip plots. Web version at peartree.live | desktop apps to follow at github.com/artic-network/peartree/releases/latest
Ten years after the release of version 1.0, we are happy to announce version 2.0 of the toolbox “seraphim”, our R package for studying phylogenetically informed movements in molecular epidemiology studies - 1/4
Applications are open for the 2026 Metagenomic Virus Discovery Workshop! The Centre for Epidemic Response and Innovation, Stellenbosch University is hosting a 5 day hands-on workshop run by experts in the field from around the world Find out more at our website mvdworkshop.com
We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !
Deltaviruses spread through a viral Trojan Horse
Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
sciencedirect.com
Wonderful to host @jonathonmifsud.bsky.social at UQ today for the SCMB Seminar Series. An excellent journey using protein structural information to study viral evolution across deep time, including new insights into the evolutionary history of Flaviviridae (RIP) and viral membrane fusion mechanisms.
APSPM brought together researchers from around the world to explore protein evolution from different angles. Structural approaches are reshaping evolutionary inference and the community is growing. Huge thanks to participants and @official-smbe.bsky.social for making this meeting a success. #StryPhy
What a great conference!! Leaving Brisbane inspired about the future of structural phylogenetics! Thanks again to the organisers @cpuentelelievre.bsky.social @proteinmechanic.bsky.social and Jordan Douglas for an amazing work putting it all together!
Great to chair the session on Virus Evolution at APSPM2026. Thank you to all the speakers for sharing their cool research with us 🦠 Mihnea Bostina, Cinthy Jimenez Silva, @spyroslytras.bsky.social @jonathonmifsud.bsky.social #StryPhy26
Our discovery of novel viruses in invasive camelids in Australia leads us to propose a simple idea: RNA viruses may repeatedly evolve functional modules at the 5′ end of their genomes. #Virology #RNAvirus #VirusEvolution #Picornavirus #VirusDiscovery doi.org/10.64898/202...
doi.org
Our paper on inferring context dependent entropy using protein language models is officially out in NAR Genomics & Bioinformatics! 🧬🤖 with Adam Strange, Jumpei Ito, and @systemsvirology.bsky.social academic.oup.com/nargab/artic... details below... #NARGAB
Inferring context-specific site variation with evotuned protein language models
Abstract. Multiple sequence alignments (MSAs) have been traditionally used for making inferences about site-specific diversity in proteins. Recent advancem
academic.oup.com
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
science.org
The program for the SMBE Australasian Protein Structural Phylogenetics Meeting 2026 is now out! Abstract book coming soon. @official-smbe.bsky.social @proteinmechanic.bsky.social biosig.lab.uq.edu.au/strphy26/pro...
APSPM 2026: Structural Phylogenetics Meeting
A pivotal SMBE regional meeting in Brisbane on the interface of protein structure, function, and evolution.
biosig.lab.uq.edu.au
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring! mirdita.org
Mirdita Lab - Laboratory for Computational Biology & Molecular Machine Learning
Mirdita Lab builds scalable bioinformatics methods.
mirdita.org
An interesting way to look at encoded structural characters to build alignments and trees downstream. This takes structural phylogenetics one step further in the post-AlphaFold era. #Evolution #Science #StrPhy On Confidence Assessment in Structure-Aware Alignments doi.org/10.1093/gbe/...
Structome-AlignViewer: On Confidence Assessment in Structure-Aware Alignments
Abstract. Protein structure-based comparison provides a framework for uncovering deep evolutionary relationships that can escape conventional sequence-base
doi.org
Phold's manuscript is now available @narjournal.bsky.social thanks to @susiegriggo.bsky.social @npbhavya.bsky.social @vijinim.bsky.social @linsalrob.bsky.social @martinsteinegger.bsky.social @milot.bsky.social @eunbelivable.bsky.social & others not on bsky #phagesky academic.oup.com/nar/article/...
Protein structure-informed bacteriophage genome annotation with Phold
Abstract. Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents.
academic.oup.com
Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n www.biorxiv.org/content/10.1...
Foraging ecology drives viral community structure in New Zealand's aquatic birds www.biorxiv.org/content/10.6...
Foraging ecology drives viral community structure in New Zealand's aquatic birds
Wild migratory birds play a major role in the global spread of viruses, yet the diversity, host range and transmission patterns of viruses harboured by migratory species in Aotearoa/New Zealand remain...
biorxiv.org
Guess the news is officially out! Extremely excited to announce that I will be starting my own laboratory at Institut Pasteur @pasteur.fr this coming spring! Slight change to my office window view from Tokyo Tower🗼 to the Tour Eiffel. 🇫🇷
I'm excited to introduce our new workflow for detecting endogenous viral elements - HI-FEVER. 🖥️🧬 academic.oup.com/bioinformati... 🧵 Big thanks to @ariskatzourakis.bsky.social, @humanceae.bsky.social, José Gabriel and Cormac for bringing this from conception to fruition!
HI-FEVER: a Nextflow pipeline for the high-throughput discovery and annotation of endogenous viral elements
AbstractSummary. Endogenous viral elements (EVEs) offer valuable insights into virus and host evolution, but their detection remains computationally and bi
academic.oup.com
Join us tomorrow! Joana Pereira is talking about AI-powered classification and discovery across the protein universe. @joanampereira.bsky.social 5PM CET, link in the post and in our bio.
The next ProSE Seminar will be given by Joana Pereira @joanampereira.bsky.social (VIB, KU Leuven) 🗓️ November 11th, 5pm CET Registration is now open: tinyurl.com/prose-seminar2 Please share!
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄 A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think. Our at-scale AI structure prediction gave a complementary perspective on viral evolution. www.nature.com/articles/s41...
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
nature.com