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Petya Krasteva

@krastevalab.bsky.social

Structural biologist and microbiologist at the IECB, CNRS, Bordeaux. Loves her kiddos, homies, science and bacteria! www.krasteva-lab.com

39 Posts1851 Follower2241 Folgt
Kresten Lindorff-Larsen@lindorfflarsen.bsky.social · last yr.

This paper combines two sort-of-crazy (in the best sense) approaches in cryoEM sample preparation: (1) Native, soft-landing electrospray ion beam deposition, followed by (2) deposition of amorphous ice, and reheating and freezing by laser flash melting. Has potential for time-resolved studies.

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bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.

Cryo-EM Sample Preparation with Soft-Landing and Laser Flash Melting https://www.biorxiv.org/content/10.1101/2025.06.05.657968v1

Joshua J. Friedman@joshuajfriedman.com · last yr.

NEW: Judge Burroughs GRANTS Harvard's requested TRO against the Trump administration, blocking it from revoking Harvard's ability to enroll international students during early court proceedings.

ORDER GRANTING PLAINTIFF'S MOTION FOR A TEMPORARY RESTRAINING ORDER For purposes of Federal Rule of Civil Procedure 65(b), the President and Fellows of Harvard College ("Plaintiff") has made a sufficient showing that it has provided notice to Defendants Department of Homeland Security, Kristi Noem, Immigration and Customs Enforcement, Todd Lyons, Department of Justice, Pamela Bondi, Student and Exchange Visitor Program, Jim Hicks, Department of State, and Marco Rubio (collectively, "Defendants") and that, unless its Motion for a Temporary Restraining Order ("TRO"), [ECF No. 4 (the "Motion")], is granted, it will sustain immediate and irreparable injury before there is an opportunity to hear from all parties. Thus, a TRO is justified to preserve the status quo pending a hearing and the Plaintiff's Motion is GRANTED. Accordingly, Defendants, their agents, and anyone acting in concert or participation with Defendants are hereby enjoined from: A. Implementing, instituting, maintaining, or giving effect to the revocation of Plaintiff's SEVP certification; B. Giving any force or effect to the Department of Homeland Security's May 22, 2025 Revocation Notice. It is so ordered May 23, 2025 /s/Allison D. Burroughs ALLISON D. BURROUGHS U.S. DISTRICT JUDGE
Joshua J. Friedman@joshuajfriedman.com · last yr.

NEW: Here's Harvard's emergency motion for a temporary restraining order against the Trump admin, asking the court to block the govt from revoking its ability to enroll international students. storage.courtlistener.com/recap/gov.us...

INTRODUCTION For more than 70 years, Harvard University ("Harvard" or the "University") has been certified by the federal government to enroll international students under the F-1 visa program, and it has long been designated as an exchange visitor program sponsor to host J-1 nonimmigrants. Harvard has, over this time, developed programs and degrees tailored to its international students and invested millions to recruit the most talented such students and integrate them into all aspects of the Harvard community. Yesterday, the government abruptly revoked Harvard's certification to host F-1 and J-1 students' without process or cause, to devastating effect for Harvard and more than 7,000 Harvard students and affiliates on F-1 and J-1 visas. The government's revocation of Harvard's certification was not a product of the ordinary review process set out in detailed regulations that define the limited circumstances under which a school's certification may be revoked and put a premium on the due process rights of institutions and students. On its face, the revocation is part of the government's broader effort to retaliate against Harvard for its refusal to surrender its academic independence? In response to the government's disagreement with the perceived viewpoints of Harvard, its faculty, and its students, the government issued a series of demands requiring Harvard to submit to government oversight Scholars and others at the University also could have J-1 visa status and thus be affected by the revocation. ≥ This case stems from the same campaign of retaliation as described in President and Fellows of Harvard College v. U.S. Department of Health and Human Services et al., No. 25-cv-11048 (D. Mass. Apr. 21, 2025) (the "Funding Case"), in which Harvard has challenged the government's freeze and terminations of billions of dollars in multi-year grants to Harvard. DHS's revocation of Harvard's longstanding certification to enroll international students involves a different a…
Ewan Birney@ewanbirney.bsky.social · last yr.

This is just an excellent preprint by Rasmus Jensen and colleagues from Julia Mahamid's lab @embl.org - a tour de force of Cryogenic electron tomography to do in cell structural biology in which they discover a new complex and solve its structure and function! www.biorxiv.org/content/10.1...

In-cell discovery and characterization of a non-canonical bacterial protein translocation-folding complex

Cryo-electron tomography has emerged as powerful technology for in-cell structural biology, and in combination with breakthroughs in protein structure prediction, offers a unique opportunity for illum...

biorxiv.org

Petya Krasteva @krastevalab.bsky.social · last yr.

Fellow ladies in science, as part of the disappearing species of international female scientists in France and perhaps every/elsewhere, I want to bring your special attention to our institute's open call for group leaders 👩‍🔬🦠🧪🔬🤓!!! Come join me in doing some coolicious science here 🙏!

IECB Bordeaux@iecb.bsky.social · last yr.

We are recruiting 🤩🤩🤩!!! If you are looking to establish your lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, all in a near-paradisiac city in the south-west of France, you have 6 weeks left to submit your application 🤓!!!

European Research Council (ERC)@erc.europa.eu · last yr.

🦠 Most #bacteria form #biofilms, protective communities that resist #antibiotics. Petya Krasteva's research explores the structure & behaviour of these biofilms, hoping to develop new #antimicrobial strategies. Read more 👉 buff.ly/YajqauG @krastevalab.bsky.social @iecb.bsky.social @CNRS.fr

Deciphering the formation of cooperative multicellular biofilms

Bacterial films are a hazard throughout the healthcare system, and as antibiotic resistance increases there is an even greater imperative...

buff.ly

@antoineloquet.bsky.social · last yr.

Check our study in press in JACS on the use of solid-state #NMR to investigate polysaccharides in encapsulated pathogens, demonstrated on #Cryptococcus neoformans. Congrats to Alons Lends and all coworkers @iecb.bsky.social @cnrs.fr @univbordeaux.bsky.social pubs.acs.org/doi/10.1021/...

Molecular Distinction of Cell Wall and Capsular Polysaccharides in Encapsulated Pathogens by In Situ Magic-Angle Spinning NMR Techniques

Pathogenic fungal and bacterial cells are enveloped within a cell wall, a molecular barrier at their cell surface, and a critical architecture that constantly evolves during pathogenesis. Understandin...

pubs.acs.org

Petya Krasteva @krastevalab.bsky.social · last yr.

Welcome to Bluesky and thank you for this post 🙏. Indeed it was a real rollercoaster and this grant came as a lifeboat in the cold and lifeless ocean of public research in France, where institutional support is a net negative 😄. So we'll rock on for another 5 years while ignoring admin emails 🤘🤘🤘

Dr Ino Agrafioti@inoagrafioti.bsky.social · 2y ago

Bizarrely,it's those just below funding line panels are most happy for.So,HUGEcongratulations to:Anais Menny&Wojciech Nawrocki(STG),@duxinlab.bsky.social & @krastevalab.bsky.social (COG),Helle Ulrich& @nynkedekkerlab.bsky.social (ADG)!Your rollercoaster had happy end! erc.europa.eu/news-events/...

Sean D. Stacey, Ph.D.@seandstacey.bsky.social · 2y ago

OK, this is just a damn cool article 🤯 🦠 🔬 Infecting the cell nucleus, gaining nutrients, but preventing cell death! www.nature.com/articles/s41...

An intranuclear bacterial parasite of deep-sea mussels expresses apoptosis inhibitors acquired from its host - Nature Microbiology

‘Candidatus Endonucleobacter’ is a pathogen of deep-sea mussels that can successfully reproduce in the nuclei of its host by expressing inhibitors of apoptosis, likely acquired through horizontal gene...

nature.com

DjuranovicLab at Brown University RNA Center@djuranoviclab.bsky.social · 2y ago

@djuranoviclab.bsky.social will be Djuranovic lab at Brown University and newly formed RNA Center from July 1st 2025. Postdoc as well as staff scientist positions will be available. www.brown.edu/news/2024-02...

Changing the future of medicine: How Brown is becoming a global hub for RNA research

The ambitious goal of the new Brown RNA Center is to untangle the mysteries of human RNA, which could be instrumental in preventing and developing treatments for a wide variety of complex diseases.

brown.edu

IECB Bordeaux@iecb.bsky.social · 2y ago

Join us in December for a week of daily matinées in Molecular Biophysics 🤩!!! Speaker line-up below, the venue is our IECB amphitheater, doors open at 10:30 for a snack and chat before exciting science 🤓!

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Mikayel Aznauryan@mazna.bsky.social · 2y ago

I put this here to acquaint our newly growing bsky network with our recent work on how the disordered translation factor eIF4B navigates accross its self-association landscape encoded by its peculiar sequence and plasticity. rdcu.be/dZCaJ

Disordered regions of human eIF4B orchestrate a dynamic self-association landscape

Nature Communications - This study reveals how the intrinsically disordered region of eIF4B governs its transition from monomers to oligomers and condensed droplets, providing key insights into how...

rdcu.be

Petya Krasteva @krastevalab.bsky.social · 2y ago

Seeing so many new members and groups here 🥰 I am resuming activity on my account to stay in touch with disillusioned colleagues and friends leaving X and to clean my feed from BS. Staying on X however, as I believe we need more outreach than ever and less, not more, bubbles in science and society!

Petya Krasteva @krastevalab.bsky.social · 2y ago

Happy to share this 👶 peer-reviewed here: we crack how E. coli and proteobacteria assemble cellulose secretion systems to recruit proxies for polymer decoration and nanomolar c-di-GMP sensing and diversify an otherwise boring synthase with low c-di-GMP affinity and 1 sugar-1 linkage mechanism!

Structural basis for synthase activation and cellulose modification in the E. coli Type II Bcs secretion system - Nature Communications

Bacteria can synthesize and secrete cellulosic polymers using membrane-associated multiprotein complexes consisting of cellulose synthases and accessory subunits. Here, Anso et al. use cryogenic elect...

nature.com