Memory reactivation underlies experience-dependent adaptive regulation of sleep

Recent memories are consolidated during sleep by spontaneous reactivation. However, whether and how memory reactivation affects sleep dynamics remain unclear. By tracking and modulating memory activit...

science.org

biorxiv.org

Interpreting human sleep activity through neural contrastive learning

Chen et al. collect a large human sleep dataset and develop Sleep Interpreter, a cross-domain neural decoder trained with contrastive learning to align waking and sleeping activity and read out semant...

cell.com

biorxiv.org

Entrained cortical delta–spindle activity, not periodic synchrony, prevents arousal by NREM thalamic bursts - Communications Biology

Thalamic bursts can awaken the cortex during wakefulness. Contrary to in-vitro–based assumptions, in-vivo NREM thalamic bursts lack rhythmic synchronization, and their failure to awaken the cortex ref...

nature.com

Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals - Nature Neuroscience

Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping our understanding of the ev...

nature.com

An open science resource for accelerating scalable digital health research in autism and other neurodevelopmental conditions - Nature Neuroscience

This paper describes the Simons Sleep Project, an open resource designed to accelerate research into the sleep and daily behaviors of autistic children using synchronized recordings from multiple wear...

nature.com

A hippocampal ‘sharp-wave sleep’ state that is dissociable from cortical sleep - Nature Neuroscience

Through continuous multiday recordings in rats, the authors reveal that hippocampal sharp waves reflect sleep need and define a homeostatically regulated sleep state that enables the hippocampus to di...

nature.com

VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation

Activity of VTA dopaminergic neurons during NREM sleep facilitates motor memory consolidation and is coordinated with spindles.

science.org

Wake consolidates event memory, sleep binds it with context

Sleep is thought to be superior to wakefulness in consolidating memory, due to a hippocampus-driven process enhancing the contextual integration of events. We compared recall of associative memory in ...

biorxiv.org

Simultaneous stomach-brain electrophysiology reveals dynamic coupling in human sleep

Sleep involves continuous communication between the brain and body, yet the dynamics of peripheral signals during human sleep remain poorly understood. Here we tested whether gastric electrophysiology...

biorxiv.org

Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics - Nature Neuroscience

Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...

nature.com

Falling asleep follows a predictable bifurcation dynamic - Nature Neuroscience

Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...

nature.com

Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans

Hemispherotomy is a neurosurgical procedure for treating refractory epilepsy by disconnecting a significant portion of the cortex. This study shows that the isolated cortex exhibits EEG patterns resem...

dx.plos.org

Head-direction cells as a neural compass in bats navigating outdoors on a remote oceanic island

Animals and humans rely on their navigation skills to survive. However, spatial neurons in the brain’s “navigation circuit” had not previously been studied under real-world conditions. We conducted an...

science.org

Convergent Control of NREM Sleep and Anesthesia by Prefrontal Layer 5 Extratelencephalic Neurons

The cortical mechanisms that actively suppress consciousness remain poorly understood. Here, we identify a specific subset of prefrontal cortical (PFC) neurons preferentially active under anesthesia w...

biorxiv.org

Arousal as a universal embedding for spatiotemporal brain dynamics - Nature

Reframing of arousal as a latent dynamical system can reconstruct multidimensional measurements of large-scale spatiotemporal brain dynamics on the timescale of seconds in mice.

nature.com

Bidirectional modulation of sleep and wakefulness via prefrontal cortical chemogenetics

The drive to sleep is inescapable but its biological substrate remains largely elusive. Until recently, the search for sleep centres in the mammalian brain focussed on subcortical neurons that promote...

biorxiv.org

An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening

The locus coeruleus has a specialized pathway to the brainstem that controls sound-evoked awakening from sleep.

science.org

Aperiodic EEG Activity Provides a Linear, Bidirectional, and Spatially Uniform Marker of Subjective and Objective Vigilance in Humans, Both Within and Across States

Vigilance is increasingly conceived as a continuum, ranging from full alertness to deep sleep. Despite its fundamental role in cognition, behaviour, and health, reliable physiological markers of vigil...

biorxiv.org

Sleep-like slow waves during wakefulness uncover a malignant form of Parkinson’s disease

Slow waves during sleep are fundamental for neural homeostasis, metabolic regulation, and waste clearance, and are known to be altered in neurodegenerative diseases. Sleep-like slow waves (SLSW) have ...

medrxiv.org

Rate and noise in human amygdala drive increased exploration in aversive learning

Nature - Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.

rdcu.be

Human hippocampal ripples align new experiences with a grid-like schema

Xiao et al. show that brief bursts of hippocampal activity (ripples) help the brain link new experiences into an internal “mental map.” During rest, ripples engage a medial frontal brain region that o...

cell.com