The International Conference on Retinal Proteins (ICRP2026) registration and abstract submission are now opened!!! www.congressi.unisi.it/retinalprote...
Ofer Yizhar
@oyiz.bsky.social
Neuroscientist at the Weizmann Institute. Neural circuits for social behavior, memory and decisions; developer of optogenetic tools. Outside the lab, it’s family, running, music in many forms.
The field is buzzing about work on brain-computer interfaces for speech, the mechanism of psychedelics, a broader definition of hippocampal representations and more. www.thetransmitter.org/community/th... #neuroskyence #StateOfNeuroscience
The buzziest neuroscience papers of 2023, 2024
The field took note of work on brain-computer interfaces for speech, the mechanism of psychedelics, defining hippocampal representations, and more.
thetransmitter.org
Our microbial-opsin work (and most of the field ) is basic science, but it was intriguing to review clinical progress–direct & indirect–with a wonderful team of co-authors t.co/JrJen2WGBV & adapt a fig. of PMID:28912215 (2017) with my long-time collaborator Peter Hegemann (pic: a memory from 2017).
Breaking a hiatus to post this. A group of Israeli Social Psychologists, myself included, wrote a letter to speak out clearly against the Israeli government’s decisions and the resulting devastation in Gaza. docs.google.com/document/d/1... In hopes of peace and safety for all, and soon
A Letter by Israeli Social Psychologists
Dear friends of the Social Psychology community, After October 7, a group of Israeli social psychologists, including many of us, wrote a letter expressing our deep shock at the massacre, abuse, rape,...
docs.google.com
Very cool study by @oyiz.bsky.social using optogenetics to shed light on how oxytocin signaling regulates vocalization to maintain maternal bonds (with nice write-up by @bellonec.bsky.social, “Cries into ties” indeed) 🧪 www.science.org/doi/10.1126/...
Cries into ties
Oxytocin neurons in mouse pups regulate vocalization to maintain maternal bonds
science.org
Excited to share our latest paper - now out in @science.org - we showed how oxytocin modulates maternally-directed behavior in young mice (P15).
In the past year and a half, we have been intensively protesting and fighting the Israeli government in an attempt to stop the war, secure the release of all hostages, and prevent the ongoing humanitarian crisis. Until now, our protests have primarily been focused internally.
What time is it? ⏰ Time to talk about the brain! 🧠 Opening the Neurotechnologies plenary session is @oyiz.bsky.social of Weizmann Inst. of Science. He is discussing new tools that allow highly light-sensitive silencing AND facilitate spectral multiplexing for modulation + imaging. #PhotonicsWest
First post on Bluesky!✨ (1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB www.biorxiv.org/content/10.1...
biorxiv.org
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
youtube.com
Related to this, I created a starter pack for those interested/involved in Epilepsy research. Many of the DBS folks may also be interested. go.bsky.app/B8pPi1n
Upon popular demand I created a started pack for people interested in Deep Brain Stimulation! Lmk if you'd like to be added! go.bsky.app/B9A9Cho
How to rebuild your network on @bsky.app and improve your experience here? I made a short starter guide with resources. www.neuronaldynamics.eu/resources/bl... Also, a thread 🧵 below.
One difference is that the DIO approach leads to the permanent removal of DNA, making it irreversible. For SIO an equilibrium between forward and reverse recombinantion is created. However the reverse probability is low, creating a bias to the activated state. In practice expression levels are good.
Ofer Yizhar@oyiz.bsky.social · 2y agoThe lox66/71 idea is not new - it came from this paper: pmc.ncbi.nlm.nih.gov/articles/PMC... by Beat Lutz. It was just never used in AAV as far as we know. The idea is that after Cre recombination between these two sites, the resulting sites are no longer recognized by Cre and can't recombine again
Important paper! www.biorxiv.org/content/bior... Im not sure the Discussion fully delineates its radical implications. No more... * Place cells * Grid cells, splitter cells, border cells * Mirror neurons * Reward neurons * Conflict cells (continued)
biorxiv.org
A moment in time: Dieter Oesterhelt passed away in Münich on this day (November 28) in 2022. He identified the 1st microbial rhodopsin more than 50 years ago, with far-reaching impact that could hardly have been imagined. laskerfoundation.org/in-memoriam-...
Many people have asked me what's the deal with "SIO" in our Addgene vectors (www.addgene.org/Ofer_Yizhar/) - we use these in most of our Cre-dependent AAVs - so here's a brief explanation of how it works.
addgene.org
PdCO has now been distributed 100x via @addgene.bsky.social 🥳🥳🥳🙏🙏🙏
Jonas Wietek@jwietek.bsky.social · 2y agoAgainst all odds: PdCO, a versatile switchable optogenetic tool for inhibiting synaptic transmission in neuronal terminals in vivo is finally published @naturemethods #neuroskyence #optogenetics www.nature.com/articles/s41...
Announcing a new open access textbook for entry level behavioral neuro. Funded by NSF. Written by a collection of 26 neuro experts. Method demonstration videos and author interviews too. Consider using it in your courses to reduce financial barriers to education. openstax.org/details/book...
We’re seeking a postdoc/student excited about animal communication, brain-wide circuits, microscopy, singing fish (Danionella), wacky ideas and who likes to: get things done, experiment, analyze, ask, learn, help and cooperate. jlab.berlin
Hello bluesky please accept this offering of a picture from my recent run with @franklandlab.bsky.social
