Huge congratulations to Dr. Pius Galli on successfully defending his PhD at @biozentrum.unibas.ch! 🎉👏 Halfway through his PhD, Pius moved from FMI @fmiscience.bsky.social in Basel to EPFL, where he completed the final part of his research.

I'm giving a seminar to present this work at EPFL @epflimaging.bsky.social, hosted by @beatfierz.bsky.social and @labthoma.bsky.social. Please come by if you're around campus on Tue 22nd Sept, 4:15pm (details: memento.epfl.ch/event/chroma...).

Congrats to Pius, Shuhao, and the team! Check out our latest publication: Molecular glue degraders (MGDs) like lenalidomide have transformed multiple myeloma treatment by inducing degradation of non-native substrates via the CRL4CRBN E3 ligase—but which proteins can they actually reach?

Our cells pack DNA into tiny bundles that hide important parts. Researchers at the FMI and EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. www.fmi.ch/news-events/...

How DNA packaging controls the “genome’s guardian”

Our cells tightly pack DNA into structures called nucleosomes, which protect DNA but also hide important sites. The key cancer-fighting protein p53 can still access these hidden sites, especially at n...

fmi.ch

Congrats to all the authors on our latest work! We reveal how p53 interacts with chromatin and show, via ubiquitin-related factors USP7 and E6-E6AP, that only specific cofactors can co-reside on nucleosomes together with p53. tinyurl.com/2feuezvj @csandate.bsky.social @deyasinic.bsky.social

📝 🚨 Review alert from the Thomä Lab @alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action. tinyurl.com/mpmbuuky

Primed for degradation: How weak protein interactions enable molecular glue degraders

Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…

tinyurl.com