Laura Mike

@lauraamike.bsky.social

Mike Lab @ Pitt-ID www.themikelab.com Studying how Kleb regulates capsule properties and causes infection #klebclub | #newPI

Join me on Monday 7/20 to learn about understudied uropathogens. Details at the link below: Utiga.org/upcoming

UTI Global Alliance@globaluti.bsky.social · 2mo ago

Our next #UTIhour on understudied uropathogens is WEEK! 🦠 Our host Dr. @lauraamike.bsky.social has assembled a dream team of speakers. She herself is in the #KlebClub - she studies #Klebsiella at @Pittdeptofmed.bsky.social! 📅 7/20 1:30PM EDT / 1700 UTC 🔗 UTIGA.org/upcoming #UTIsky #IDSky

TODAY!! Join us for Session 3 of #KlebClub2026 📅 April 23rd ⏰ 9:00–10:30 AM EDT 🔬 Theme: Translational Microbiology Hear from researchers bridging bench to bedside and explore innovative approaches to tackling Klebsiella pneumoniae. ✨ Free registration ->scan the QR code on poster

klebclub flier

journals.asm.org/doi/10.1128/... Proud to see our work published in mBio! We uncover how C3 and C4 provide layered immune protection against Klebsiella pneumoniae. Grateful for my incredible mentors Dr. Ammar Zafar @azmicro.bsky.social, Dr. Karen Haas and supportive colleagues.

Divergent roles for complement components C3 and C4 in controlling Klebsiella pneumoniae gut colonization and systemic dissemination | mBio

Klebsiella pneumoniae, a major public health threat, resists antibiotics and can spread from the gut to the bloodstream, causing severe infections. Our study reveals how the immune system uses complement proteins C3 and C4 to block this spread. C3 limits bacterial growth in the gut through two potential mechanisms: (i) coating K. pneumoniae with fragments that signal bacteria-eating phagocytic cells to destroy it and (ii) recruiting more phagocytes into the gut. C3 also helps clear bacteria that escape into the blood. However, when antibiotic-resistant strains overgrow, C3 alone is insufficient. In these cases, C4 becomes critical, likely by enhancing C3’s ability to tag bacteria for elimination. This two-layered defense highlights new immune pathways that could be targeted to prevent bloodstream infections, especially in vulnerable patients or those colonized with drug-resistant bacteria. These insights open doors to innovative strategies against life-threatening Klebsiella infections.

journals.asm.org

Daisy is a healthy pup, but she's still pawsitively devoted to supporting animals' urinary health ❤️🐶 That's why our #UTIhour on October 14th (12EDT) is on veterinary #UTI! Do you have a furry friend who supports urinary health? Post a photo and tag us or send it here to post

A white dog curled up on a fluffy black bed with her ball