I am excited to share our new paper, where we developed and used a new approach that allows us to dynamically monitor autophagy in the intact mouse brain! biorxiv.org/cgi/content/...

Fluorescence lifetime-based biosensor for monitoring compartmentalized autophagy dynamics in the intact mammalian brain

Synaptic architecture underlies neuronal computation, with autophagy serving as a key regulator of synaptic plasticity, function and local metabolism. Yet, autophagy dynamics and regulation within int...

biorxiv.org

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods

A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...

nature.com

Yesterday, we held the 2024 Sieratzki Prizes Ceremony at the ISFN meeting in Eilat. We are so proud of our 2024 winners: @yoavlivneh.bsky.social , Arseny Finkelstein, David Omer, @lavivtal.bsky.social, and Inbal Ben-Ami Bartal!

How to improve memory and cognitive function in aged mice Fix the mitochondrial EC (excitation-coupling) @science.org representing a new potential path for replenishing neuronal energy reserves to counter brain aging www.science.org/doi/10.1126/...

Beautiful work by my the lab of Huan Ma, which I had the pleasure to contribute to. A fascinating link between neuronal activity, and transcription-excitation coupling in mitochodria to brain function and ageing www.science.org/doi/10.1126/...

Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice

Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitoc...

science.org

Hello there! My first try here: Sharing an in vivo image of a beautiful dendrite with a GFP knock-in to endogenous CaMKIIa

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy www.science.org/doi/10.1126/...

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy

RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

science.org

I'm very happy with how this image turned out and can't even wait for #FluorescenceFriday! I'm trying to detect Tau protein phosphorylation before forming full fibrillary tangles in #Alzheimer disease. Healthy neurons: (🟠NeuN), Dying neurons: pTau ( 🟣422), (🔵AT8). More info in the Alt tex! 🧠🔬