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Michael Ward

@michael-e-ward.bsky.social

Physician scientist studying the biology of neurodegenerative disorders. ORCID ID: 0000-0002-5296-8051

74 Posts1480 Follower589 Folgt
Aakriti Jain@aakritijain.bsky.social · 2mo ago

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

nature.com

Subhojit Roy MD, PhD@roylab-ucsd.bsky.social · 2mo ago

Giving a talk? Don't waste time with "practice talks". Stay in slide sorter view & practice 3 things for each slide: 1. What point/s do I want to convey with this slide (</=3). 2. What's the 1-line summary of this slide? 3. What is the transition to the next slide? Something doesn't fit? FIX IT

Mark Histed@markhisted.org · 2mo ago

Triple the science budget AND fix agency governance. TLDR: Those are the two essential things we must fix in US science. Get the president out of the science agencies, no presidential influence beyond appointment, stop the attacks on the civil service, restore Congressional power and oversight.

Costa Samaras@costasamaras.com · 8mo ago

Them: I've devised an exact formula for what we should invest in science and public health and education, see my 100 page PDF and then– Me: I'm not reading all that, just triple it and go from there bsky.app/profile/cost...

Ariel Levine@ariellevine.bsky.social · 5mo ago

Check out the newest work from our, from Fabricio Nicola @fabricionicola.bsky.social on mouse jumping and spinal cell types. Excellent collab with @vulcnethologist.bsky.social www.biorxiv.org/content/10.6...

A spinal substrate for modular control of natural behavior

Natural behavior unfolds as coordinated sequences of body movements. This organization suggests that behavior may be built from discrete motor patterns, yet how such arrangements are implemented by neural circuits remains unknown. Here, we combined kinematic analysis, muscle recordings, genetically identified cell types, and closed-loop optogenetic perturbations to examine the organizational logic of natural gap-crossing jumps in mice. Jumping was characterized by a series of precisely defined phases and their associated modular motor patterns. The core phases, propulsion and flight, exhibited distinct signatures of neural control, including unique bursts of coordinated hindlimb muscle activity, differential tuning strategies for jump distance, and active requirements for spinal neural drive. Mapping activity across lumbar interneuron populations and functionally screening candidate cell types for their ability to drive coordinated movement revealed that a population of dorsal excitatory dILB6 neurons can autonomously evoke coordinated multi-joint hindlimb flexion characteristic of the jumping flight phase, across behavioral contexts. These findings provide a specific cellular substrate for the long-standing concept of spinal modular motor control: a flexible, preconfigured motor template that the mammalian CNS can recruit and modulate to meet the demands of natural behavior. ### Competing Interest Statement The authors have declared no competing interest. Intramural Research Program of the National Institutes of Health (NIH)

biorxiv.org

Fabricio Nicola@fabricionicola.bsky.social · 5mo ago

Mammals have hundreds of joints and muscles. Controlling them individually would be nearly impossible. How does the nervous system organize such complexity into coherent actions? Our new study explores this question through a natural behavior: jumping.

Mark Histed@markhisted.org · 5mo ago

The most impt change at #NIH and to US science this year is bigger than grant cancellations— it’s how the agency is governed. For 75 years NIH has been largely independent of presidential control. That’s changed this year. New piece from me and @nataliebaviles.bsky.social in @nature.com 🧪

How Congress can restore the independence of US science

Members must go beyond reinstating US government research spending and re-establish decentralized governance at the National Institutes of Health and other agencies.

nature.com

Science Magazine@science.org · 5mo ago

A new #ScienceSignaling study offers insights into the KOLF2.IJ cell line, which is derived from induced pluripotent stem cells and has been proposed as a neuronal model for Alzheimer’s disease and related #dementia research. https://scim.ag/4aFNY9O

Temporal proteomic and phosphoproteomic dynamics during neuronal differentiation in the reference iPSC line KOLF2.1J

Trace protein and phosphoprotein dynamics during neuronal differentiation in the iPSC-derived cell line model are described.

scim.ag

James Olzmann@olzmannlab.bsky.social · 5mo ago

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly - Nature

CRISPR–Cas9 screening identifies CLCC1 as a factor that increases neutral lipid flux to prevent hepatic steatosis and promotes nuclear pore complex assembly&nbsp;by promoting membrane bending and fusi...

nature.com

Takeshi Uenaka@tuenaka.bsky.social · 6mo ago

Losing sleep over #iPSC transgene silencing after differentiation? Same here. Bright in iPSCs. Gone after differentiation. Our paper in @cp-cellstemcell.bsky.social maps what actually keeps expression on👇 www.cell.com/cell-stem-ce... 🔗 Free access (50 days): www.sciencedirect.com/science/auth...

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sciencedirect.com

Molly Gale (Gale-Hammell Lab)@mollygale.bsky.social · 7mo ago

📣Excited to announce a new pre-print from the lab 📣 Led by my student @storiesofisobel.bsky.social in collab with Hemali Phatnani @nygenome.org We discovered a novel class of TDP-43 dependent cryptic gene-TE spliced transcripts: crypTEs #TEsky #RNAsky #ALS doi.org/10.64898/2026.01.09.698641

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues

TDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accumulation of cryptic splice isoforms that result from im...

doi.org

Dr. Becca@docbecca.bsky.social · 8mo ago

Begging PhD programs to agree on a common app with only letters of rec that writers upload once. These inane likert scales when students are applying to 15-20 programs is destroying my soul

Ranking categories found on a recommendation portal for a PhD program. It reads: Top 5%: Applicant is exceptional in this category and is among the best I've collaborated with in my career Top 10%: Applicant has demonstrated consistent excellence and has performed well above the average of their peers in this category Top 25%: Applicant has consistently performed above the average of their peers in this category Top Half: Applicant has consistently performed at an average level or midpoint of their peer group's performance in this category Bottom Half: Applicant has consistently performed below the average of their peers in this category No Basis for Judgement: I have not interacted with the applicant in a manner that allows me to fairly assess their competency in this category