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Luke Yates

@layates.bsky.social

Assistant Professor in Genome Stability at University of Sussex, Brighton, UK. Visiting scientist at Francis Crick Institute & Imperial College London. Structural biologist investigating DNA damage checkpoints. Artist and charity trustee. Views are own.

12 Posts566 Follower918 Folgt
NealeLab@labneale.bsky.social · 6mo ago

Now live on Find-A-PhD-dot-com: Joint project between @labneale.bsky.social and @drjonbaxter.bsky.social @gdsc-sussex.bsky.social Get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis. www.findaphd.com/phds/project...

How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex on FindAPhD.com

PhD Project - How Chromosome Structure Shapes Genetic Diversity and Genome Stability at University of Sussex, listed on FindAPhD.com

findaphd.com

NealeLab@labneale.bsky.social · 7mo ago

Coming soon! PhD opening joint with @drjonbaxter.bsky.social at @gdsc-sussex.bsky.social Keep a look out and get in touch if you are interested in any and all of: Chromosomes, Genome Stability, Chromatin and DNA Topology in Mitosis and Meiosis.

Bertolin Lab@bertolinlab.bsky.social · 6mo ago

To kickstart this new Bluesky account: We're hiring! The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab. Details in the flyer — get in touch! 👇

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Uli Rass@u-rass.bsky.social · 12mo ago

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

nature.com

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · last yr.

#NEW_PAPER In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR). rdcu.be/eCGxF

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications - Centromeres play an essential function in faithful chromosome segregation. Here, the authors demonstrate the mechanism by which human cells dynamically modulate the activity...

rdcu.be

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · 12mo ago

#NEW_PAPER The Hochegger laboratory + collaborators investigate the sensitivity of cancer cells to a highly selective inhibitor of human Greatwall kinase (GWL) + the BB5alpha-to-GWL expression ratio is a predictive biomarker for the cellular reponse to Greatwall-targeted therapeutics. rdcu.be/eC4Hf

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Nature Communications - The authors develop and characterise a selective Greatwall inhibitor, C-604, and show that its cytotoxicity stems from PP2A-B55α hyperactivation. They identify...

rdcu.be

Genome Damage and Stability Centre (GDSC)@gdsc-sussex.bsky.social · 12mo ago

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

doi.org

Luke Yates@layates.bsky.social · last yr.

Published online now in @annualreviews.bsky.social Annual Review of Biochemistry, Prof Zhang @crick.ac.uk and Prof Burgers @washu.bsky.social and I summarise current mechanistic understanding of DNA damage checkpoints, which act as a barrier to cancer in humans. www.annualreviews.org/content/jour...

DNA Damage and Replication Stress Checkpoints | Annual Reviews

DNA damage checkpoints are key regulatory signaling cascades that arrest cell cycle progression upon DNA damage or upon DNA replication stalling and allow time for repair or correction. Failure to eli...

annualreviews.org

@keithcaldecott.bsky.social · 2y ago

Dear all, Postdoc positions are available to work on (1) the role of DNA strand break repair proteins during DNA replication and (2) the molecular/structural biology of XRCC1 protein complexes, as part of our work on genetic diseases & cancer. Contact me if interested: k.w.caldecott@sussex.ac.uk

Alessandro Costa@costalaboratory.bsky.social · 2y ago

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

Di Jiang@dijiang319.bsky.social · 2y ago

Online today @science.org 👀Molecular basis of FIGNL1 in dissociating RAD51 from #DNA and #chromatin by @alexcarver.bsky.social @layates.bsky.social et al. in @imperialcollegeldn.bsky.social @mskcancercenter.bsky.social www.science.org/doi/10.1126/...

Alex Carver@alexcarver.bsky.social · 2y ago

NEW in @science.org, so happy to contribute to our understanding of the molecular machine, Fidgetin-like 1 (FIGNL1), and elucidating the mechanism of why cells cannot survive when it is lost! #ScienceResearch science.org/doi/10.1126/... (1/7)