A newly minted PhD from the lab! Congratulations, Luis, on a fantastic performance and an excellent PhD defense! You can be very proud of yourself @biolm.bsky.social !

Max Perutz Labs Vienna@maxperutzlabs.ac.at · 2w ago

🎓Congratulations, Luis Miguel Cerrón Alván from the Leeb lab on successfully defending his thesis "Molecular control of formative pluripotency and the emergence of early lineage competence" - well done! 🙌🥳

📅 Save the date: November 4–6, 2026 We are happy to announce this year’s Vienna BioCenter PhD symposium: 🔬 A trail of twists and turns: non-linear paths to discovery Join us for a symposium that celebrates the unexpected journeys behind scientific breakthroughs. Stay tuned for more details!

Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state. careers.exeter.ac.uk/vacancies/79...

Register for DevSTEM by May 30: https://devstem.pages.ist.ac.at

Check out our new preprint on an unexpected role of WT1 in shaping transcriptional heterogeneity in the formative epiblast before gastrulation. Led by @biolm.bsky.social with the @leeboratory.bsky.social team! Read Luis's thread and the preprint👇 www.biorxiv.org/content/10.6...

Luis Miguel Cerron-Alvan@biolm.bsky.social · 4mo ago

When do lineage biases first emerge in the epiblast? They are detectable before gastrulation, but how this early asymmetry is established has remained unclear. A CRISPRa screen identifies WT1 as an unexpectedly early regulator of formative pluripotency. (1/4)

@nicolasrivron.bsky.social and I look to recruit a postdoc through the VIP3 rogramme to investigate post-implantation development of blastoids. Contact us if you are interested, and let your colleagues who could be interested know!

Nicolas Rivron@nicolasrivron.bsky.social · 4mo ago

Hi all! 👋 leeboratory.bsky.social and I are recruiting a VIP³ postdoc to join our teams and decode the genetic logic of how blastoids transit to the post-implantation stage. MolBio, genetics and computational approaches. If this sounds like you (or someone you know), we’d love to hear from you! 🚀

🚨 Out now! 🧫 In a new study in @embojournal.org, PhD student @moberhuemer.bsky.social (Leeb lab) presents a simpler, feeder-free way to grow human naïve pluripotent stem cells - making the system more scalable and accessible ➡️ tinyurl.com/29wrcdru @univie.ac.at @meduniwien.ac.at

Eliminating the confounding effects of human pluripotent #stemcell co-culture with MEFs: @grazianomartello.bsky.social @leeboratory.bsky.social @jzylicz.bsky.social and collaborators describe a serum coating approach for feeder-free culture of naïve hPSCs link.springer.com/article/10.1...

Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential - The EMBO Journal

Naive human pluripotent stem cells (hPSCs) represent a pre-implantation epiblast state able to efficiently differentiate into embryonic and extraembryonic pre-implantation lineages and to self-organis...

link.springer.com

🔬 Love science and keeping a lab running smoothly? Join the @leeboratory.bsky.social as a lab manager/research technician and help uncover how cells choose and maintain their identity 🧫 More information ➡️ tinyurl.com/y7a8he88

SY-Stem 2026 is here! The symposium focusing on the next generation of stem cell researchers returns to the Vienna BioCenter from 11–13 March 2026. Register online: sy-stem.org

❕The @leeboratory.bsky.social seeks a new Master's student! Your 🫵 project will involve stem cell culture, genome engineering as well as molecular biology. It aims at elucidating the genetic circuitries that regulate cell fate decisions in the early mammalian embryo ➡️ tinyurl.com/4awtk2n3

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Molecular Mechanisms of Disease. More information ➡️ tinyurl.com/3yn883b8

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury. www.nature.com/articles/s41... A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka. 🧵1/14

Reminder: deadline to apply for the Stem Cell Summer School is 30th May. And it's May already! So you have to apply this month! A limited number of bursaries are available. p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂

Stem Cell Summer School@stemcellsummer.bsky.social · last yr.

The 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses. Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀 Deadline for applications: 30th May 2025

Exciting postdoc opportunity in our group to develop new pluripotent stem cells lsi.exeter.ac.uk/groups/smith...

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @natcellbio.nature.com

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology

Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

rb.gy

We’re already warming up the motors for next week’s SY-Stem Symposium, organized by IMBA and the IMP, which focuses on the next generation of stem cell researchers and gives them the opportunity to connect and share their research with their peers. Program details here: www.sy-stem.org

SY-Stem 2025 Symposium: Registration deadline on February 15th! SY-Stem - a symposium focusing on the next generation of stem cell researchers - is organized by IMBA and @impvienna.bsky.social. Register online: bit.ly/4jekaDg Check out the program: bit.ly/4jDioM6

Come and join us for this fantastic symposium organised by oru SMICH PhD students!

SMICH - doctoral college@dksmich.bsky.social · 2y ago

‪We're excited to announce that registration for the "Tiles of Life" Student Symposium is now open! With a fantastic lineup of guest speakers, complemented by SMICH student talks, we’re set for two inspiring days. Don’t miss out—register now! 🚀🎓✨ #TilesofLife #studentsymposium #SMICH

‪We're excited to announce that registration for the "Tiles of Life" Student Symposium is now open! With a fantastic lineup of guest speakers, complemented by SMICH student talks, we’re set for two inspiring days. Don’t miss out—register now! 🚀🎓✨ #TilesofLife #studentsymposium #SMICH

Introducing the 2025 SY-Stem Speakers! This year’s symposium again features excellent speakers, and is headlined by two fantastic Keynote Speakers: Fiona Doetsch from the University of Basel and Mitinori Saitou of the ASHBi Institute of the Kyoto University.

We are happy to contribute to this exemplary collaborative study aimed at improving the efficiency of working with human naïve ESCs without MEF feeder cells. With @grazianomartello.bsky.social‬, @jzylicz.bsky.social, @pasquelab.bsky.social, and @nicolasrivron.bsky.social tinyurl.com/5n6z9rt9

Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential

Conventional human pluripotent stem cells (hPSCs) are widely used to study early embryonic development, generate somatic cells, and model diseases, with differentiation potential aligned to a post-imp...

tinyurl.com

Graziano Martello@grazianomartello.bsky.social · 2y ago

With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9

Just a few days left to submit your abstracts for a talk at the SY-Stem Symposium in Vienna! Don’t miss this chance to share your research and connect with fellow scientists. #SYStem2025

Institute of Molecular Biotechnology@imbavienna.bsky.social · 2y ago

The deadline to submit your abstract for a talk at the 2025 SY-Stem Symposium has been extended to January 22, 2025. Registration deadline remains on February 15th. For more details and to submit your abstract, visit: www.sy-stem.org We hope to see you there! #SYStem2025

Great paper from the Buecker Lab. Congratulations Henry, Songjie and Christa!

Christa Buecker@chribue.bsky.social · 2y ago

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12