Eleonora Leucci
@leuccilrcb.bsky.social
RNA and cancer biologist (opinions, usually strong, are mine) https://gbiomed.kuleuven.be/english/research/50488876/54502087/research https://gbiomed.kuleuven.be/english/research/50488876/54502087/Trace
🔬 Want spatially map validated RNA–protein interactions in biological meaningful samples? Here we mapped LISRR–RPL26 interactions in melanoma biopsies upon ICB. 💡 You can adapt it to your favourite RNA–protein pair 😉. www.cell.com/star-protoco... #RNAProteinInteractions #lncRNA #SpatialBiology
To my friends and colleagues working on #AML and other hematological malignancies, this is an excellent resource on #lincRNA expression across AML subtypes in #ncRNAjournal: www.mdpi.com/2311-553X/12...
mdpi.com
New from the lab: melanocytic lineage–specific #lncRNA DDERMAL interacts with the DNA Damage/Repair machinery. Its loss in dedifferentiated #melanoma revealed unexpected biology. Dedifferentiated cells repair damage better and are thus sensitive to #Olaparib! #iscience 💡 www.cell.com/iscience/pdf...
cell.com
If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️ We are looking for a postdoc to join our team at @imbavienna.bsky.social More details 👇🏻
Institute of Molecular Biotechnology@imbavienna.bsky.social · 5mo agoWe are hiring! Join the Jachowicz lab as a postdoctoral researcher. The project focuses on understanding the dynamics of ncRNAs using high-resolution and single-molecule microscopy approaches. Link below 👇
Passionate about transcription? 🚀 We’re recruiting a PhD student in Transcriptional Regulation at @ucph.bsky.social Start Summer 2026 Work with RNA, CRISPR, sequencing & proteomics in the Gregersen Lab @cgen2025.bsky.social Meet us: gregersenlab.com Apply by Apr 10, 2026👇 tinyurl.com/PhD-CGEN
Our atlas of lncRNAs associated with M1 and M2-like phenotype in TAMs in lung cancer is out www.nature.com/articles/s41...
Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer - Genes & Immunity
Genes & Immunity - Association of tumour-associated macrophage states with non-conserved lncrnas in lung cancer
nature.com
My review on -lncRNAs as Targetable Nodes of Oncogenic Networks Underlying Cancer Progression and Therapy Resistance - is out in the Annual Review of Cancer Biology www.annualreviews.org/content/jour...
lncRNAs as Targetable Nodes of Oncogenic Networks Underlying Cancer Progression and Therapy Resistance
The human cancer genome contains a substantial proportion of nonconserved regions that are transcribed into long noncoding RNAs (lncRNAs) and hosted in areas recurrently implicated in cancer. Due to i...
annualreviews.org
🎥 See a short video summary of the study from @leuccilrcb.bsky.social: youtu.be/AKSuTne83jQ
Assembly of cancer-specific ribosomes by the lncRNA LISRR suppresses melanoma anti-tumour immunity
Original paper: [LINK] Video summary by Eleonora Leucci (KU Leuven) Cinque et al. demonstrate that inhibition of a cancer-specific transcript makes human drug-tolerant persister cells visible to…
youtu.be
nieuws.kuleuven.be/en/content/2...
RNA molecule helps skin cancer cells evade the immune system
Researchers at KU Leuven have identified an RNA molecule that enables melanoma to hide from the immune system. When this molecule is blocked, immune cells are once again able to detect and attack the ...
nieuws.kuleuven.be
Cinque et al. @leuccilrcb.bsky.social showed that the #lncRNA LISRR contributes to the emergence of #melanoma clones resistant to the immune attack by assembling #specializedribosomes at the ER. rupress.org/jem/article/... 🎥 See a short video summary: youtu.be/AKSuTne83jQ #Ribosomes
Annuntio vobis gaudium magnum: Habemus papam! Our paper on the role of LISSR in the generation of #DTPC is out today in @jem.org rupress.org/jem/article/...
Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...
Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology
As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.
nature.com
Find in @narjournal.bsky.social our latest kPPA-CART, a new effective framework for your multi-omics analysis. 👉https://academic.oup.com/nar/article/doi/10.1093/nar/gkaf844/8257763?utm_source=authortollfreelink&utm_campaign=nar&utm_medium=email&guestAccessKey=44031ac6-ca6c-47a7-bea5-f5a13e8e45e3
Augmented kurtosis-based projection pursuit: a novel, advanced machine learning approach for multi-omics data analysis and integration
Abstract. Due to the heterogeneity of multi-omics data, exacting their maximum information potential remains a challenge. Whereas some solutions have been
academic.oup.com
Dr. Tobias Karakach@karakachlab.bsky.social · 11mo agoLike Dj Khalid, another one from the KarakachLab! We just dropped kPPA-CART in @narjournal.bsky.social, a new machine learning method that finds hidden signals in messy multi-omics data. From kidney aging 🧬 to breast cancer 🎗️, it uncovers patterns others miss. doi.org/10.1093/nar/...
The miniature trivial pursuit for the celebration of the 6th centenary of KUL arrived 😍
We have two fully funded #Postdoctoral positions: -One dark genome explorer to lead a curiosity-driven project on #lncRNA in #cancer #therapyresistance -One experienced researcher interested in working on #drugdevelopment in collaboration with industrial partners The links to apply below:
Tom Stafford@tomstafford.mastodon.online.ap.brid.gy · 2y agoI'm sure this Science story on how systematic reviews are threatened by paper mills is good, but the illustration by Sara Gironi Carnevale is great saragironicarnevale.com Story: https://www.science.org/content/article/systematic-reviews-aim-extract-broad-conclusions-many-studies-are-peril
Early-stage, curiosity-driven cancer research is the cornerstone of future medical breakthroughs. Let's #KeepResearchCurious ✨ magazine.eacr.org/keepresearch...
We are looking for a postdoc to work on #lncRNAs, #translational regulation and #Cancer. If you are passionate, curious and able to work independently please consider to to e-mail me to discuss this further.
Pls share 🌟Join the IMP as a Group Leader We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social 👉https://tinyurl.com/impgl2025
It is a pleasure to share that our work reporting a novel role for the #lncRNA ROSALIND in scavenging #ROS and protecting the #mitochondrial ribosome in drug-tolerant persister cells #DTPCs has now been published in @cddpress. Fell free to read and reshare rdcu.be/dUnoo
The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage
Cell Death & Differentiation - The long non-coding RNA ROSALIND protects the mitochondrial translational machinery from oxidative damage
rdcu.be
Thrilled to share our Roadmap to Persister Cancer Cells published in Nature Reviews Cancer. This accomplishment is the result of a collaborative effort by many experts in the field, and I’m proud to represent the RNA community among them rdcu.be/dSJp4
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities
Nature Reviews Cancer - Resistance to therapy remains the biggest challenge to achieving cures in patients with cancer. In this Roadmap, Russo et al. overview the field of cancer drug-tolerant...
rdcu.be
