Alexander Lorenz

@lorenzlab.bsky.social

Geneticist, Chromosome Biologist, wanna-be Genomicist into Meiosis, Genome Diversity, Schizosaccharomycs pombe, Candida auris. Treasurer of @gensocuk.bsky.social. University of Aberdeen @uniofaberdeen.bsky.social (Scotland, UK); posts are my own views

Just rescued a plasmid I had frozen down as E. coli stock 10 years ago, did a midi-prep with a kit older than 8 years, and diagnostic restriction digests with enzymes >10 years past their best-before date. Worked perfectly, sometimes thriftiness pays off

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Very happy to have our preprint published in Microbiological Research now doi.org/10.1016/j.mi..., we had additional help from Steven during the revision to get this over the line @chitinette.bsky.social @theafg.bsky.social @uniofaberdeen.bsky.social

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Alexander Lorenz@lorenzlab.bsky.social · 2y ago

I posted this preprint to bioRxiv already before the holiday break and didn't have time to talk about it here yet www.biorxiv.org/content/10.1... 🧬🧫🔬 Work from two of my PhD students, Zoe and Sakinah, with help from Yixin & @chitinette.bsky.social

The truth is that the scientific process is horribly inefficient and wasteful. But the solution is NOT cutting funds and it’s NOT top down guidance of what should be studied. Instead, we should revolutionize how we publish and improve peer review.

Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.

Experimental results showing DNA break formation by purified SPO11 protein. Above is an image of an electrophoresis gel, below is a graph showing quantification of the DNA cleaving activity

Here are my favourite facts from the @gensocuk.bsky.social Medal Talk and Balfour lecture. Of course much more fascinating information was also included! 1) siRNAs cause the triploid block which kills triploid maize progeny, which are bad 2) Alternative approached to getting ancient omics sequencing

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