Jürg Bähler
@jbahler.bsky.social
Geneticist, Professor at UCL, Secondment at Francis Crick Institute. fission yeast | turquoise killifish | cellular quiescence | aging | functions of understudied genes and non-coding RNAs
Do you have a bold, daring vision how to transform research in biology? Are you a young scientist within 7 years since your PhD? Submit your idea by July 31 to the Dream Biology Award competition and you can win the first prize of €10,000! More details at dreambiologyaward.org
This project from @jbahler.bsky.social lab at @ucl.ac.uk's Genetics Evolution and Environment (GEE) department came out of a summer project from Celeste Cohen and a very productive masters project from first author @bencekover.bsky.social.
Someone requested #GoldenBraid Assembly, now it's live on #OpenCloning. Still missing the omega Level 1 assembly (coming very soon). For GoldenBraid reference: goldenbraidpro.com and pmc.ncbi.nlm.nih.gov/articles/PMC...
#OpenCloning is shaping up to be a really useful tool, and the new Assembler is powerful for defining and using Golden Gate syntaxes. Give it a try!
Manuel Lera-Ramirez@manu-lera.bsky.social · 6mo ago🚀 Excited to launch the #OpenCloning Assembler! 🧬 Built to demystify Golden Gate for beginners and save time for experts -> MoClo assembly blazing fast ⚡ ✍️ Use existing syntaxes or design your own! #SynBio #GoldenGate #MoClo #OpenSource #Biotech 👉 Try it: app.opencloning.org Feedback welcome!
🚀 Update from @pombase.bsky.social! Gene pages now link to OpenCloning. Load the gene region instantly and design primers + cloning strategies in one click 🧬🧪✨ To get started with OpenCloning, check the docs: docs.opencloning.org
and this one, with @jbahler.bsky.social: www.trees-dla.ac.uk/projects/evo...
The evolution of environmental responses | TREES DLA
Organisms are subject to environmental conditions that vary over time and space. To gain maximum fitness in the face of this variability, they need to adapt their phenotypes in such a way as to expres...
trees-dla.ac.uk
www.embopress.org/doi/full/10.... Here's an important and topical perspective from Nektarios Tavernarakis. Wise words!
For the love of frontier research, or why Elon’s rockets keep blowing up | EMBO reports
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
embopress.org
PomBase introduces two new interactive views for GO-CAM pathway models: Summary Maps (high-level, visual overview) and Mega-Models (connected models). Check them out here: lnkd.in/gfxNRdua
Well this is interesting: Psilocybin treatment extends cellular lifespan and improves survival of aged mice Guess all of us older adults need to stock up on mushrooms!!! www.nature.com/articles/s41...
Psilocybin treatment extends cellular lifespan and improves survival of aged mice - npj Aging
npj Aging - Psilocybin treatment extends cellular lifespan and improves survival of aged mice
nature.com
Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response. www.biorxiv.org/content/10.1...
The adaptive molecular landscape of reprogrammed telomeric sequences
Telomeric sequences vary across the tree of life and intimately co-evolve with telomere-binding protein complexes. However, the molecular mechanisms allowing organisms to adapt to new telomeric sequen...
biorxiv.org
After 25 years, it was wonderful to reunite with all members of our original research group!
FlyBase needs your help! Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org
We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).
We found a new way to make mice live 30% longer! 🧪 #aging #longevity #rapamycin A combination of classic longevity drug rapamycin with cancer drug trametinib was more effective than either on its own. Read more about the exciting results here:
New drug cocktail makes mice live 30% longer – Andrew Steele
Rapamycin + anti-cancer drug trametinib does better than rapa on its own!
andrewsteele.co.uk
We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓
A periodic reminder to cite your resources. Although no @pombase.bsky.social update in this issue, we did sneak onto the cover illustration.
Genetics Society of America@genetics-gsa.bsky.social · last yr.This issue of #GENETICS offers updates on 6 model organism databases & knowledgebases: buff.ly/Mn0hIzl 🔎 AgBioData Consortium 🔎 Candida Genome Database 🔎 Saccharomyces Genome Database 🔎 SpudDB 🔎 Unified Phenotype Ontology 🔎 Zebrafish Information Network Remember to cite your community resources!
I spent a very nice couple of days at the "Hidden Cell, Dark Genome" conference in Edinburgh last week ... and even got to win a supercute eukaryotic cell 🙂 Thanks to the organisers for arranging the meeting!
Hannah Long@hannahlong.bsky.social · last yr.With many thanks to our keynote speakers - Emily Wong @em6wong.bsky.social, Manuel Irimia @mirimiam.bsky.social, Sean Munro, Sarah Teichmann, Wolfgang Baumeister and Christine Cucinotta @chrstne.bsky.social - what a fantastic couple of days of cross-cutting science, and a lively discussion session!
You can now ✅ verify your #OpenCloning sequences using sequencing data 🧬 (Sanger or Nanopore). Just load your files 📂 and see where they align! 🎯 #OpenCloning is free & Open Source, and supports most cloning methods! 🔬🛠️ 👉 Try it here: opencloning.org 🎞️ Demo video: youtu.be/n0hedzvpW88?...
Together with fellow @biologists.bsky.social EiCs we've written about the unprecedented cuts & policy changes to research in the US We stand with our US colleagues during this challenging time Science transcends borders—setbacks in one nation affect us all journals.biologists.com/dev/article/...
Science under siege: protecting scientific progress in turbulent times
As Editors-in-Chief of The Company of Biologists' journals, we have been watching with growing concern the policy changes in the United States of America (USA) and the challenges that these are creati...
journals.biologists.com
It's time for individuals and organizations in Europe and other democratic countries to move mission- or life-critical IT services and infrastructure outside the reach of the US government; noting that US tech companies have already largely subordinated themselves. www.huber.embl.de/group/posts/...
Digital sovereignty – Huber Group @ EMBL
The US is now a mafia-style extortionist you want to stay away from
huber.embl.de
Hello everyone on Bluesky! 🧪 We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond. Read more: www.embo.org/about-embo/m...
Grant rejections got you feeling low? BSRA research grants have success rates between 35-67%! We offer our members - Small Research Grants - Travel Grants - Summer Studentships Next deadline 1st March. Know the perfect person? Tag them below! bsra.org.uk/bsra-open-gr...
'Many of us...have a feeling that we are living in a country where fanatics, hooligans and eccentrics have got the upper hand.' British Ambassador to Berlin, 1933.
You can apply to our postdoc position until 12 Jan: We are looking for a Postdoc in Functional Genomics to examine the roles of conserved yet unstudied proteins, focusing on cellular quiescence and ageing. www.ucl.ac.uk/work-at-ucl/...
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
ucl.ac.uk
www.linkedin.com/posts/global...
Global Biodata Coalition on LinkedIn: Thank you to leading scientists around the world for signing the GBC’s…
Thank you to leading scientists around the world for signing the GBC’s Open Letter calling for support to sustain global biodata resources. If you haven’t…
linkedin.com
Second PhD project now online, co-supervised by @jbahler.bsky.social. Join us to work on the genetic architecture of environmental responses in fission yeast. Tons of existing data and resources (wild strains, MA lines, evolved populations...) to dig into. www.trees-dla.ac.uk/projects/evo...
The evolution of environmental responses | TREES DLA
Organisms are subject to environmental conditions that vary over time and space. To gain maximum fitness in the face of this variability, they need to adapt their phenotypes in such a way as to expres...
trees-dla.ac.uk
There is competitive #PhD funding for 4 years (eligibility criteria apply) to do a project on the human pathogen Candidozyma (Candida) auris dissecting the genetic basis of its antimicrobial resistance #AMR www.findaphd.com/phds/project... - pls repost
EASTBIO: Harnessing Transposon Mutagenesis to Dissect Antifungal Drug Resistance in the Fungal “Superbug” Candidozyma auris at University of Aberdeen on FindAPhD.com
PhD Project - EASTBIO: Harnessing Transposon Mutagenesis to Dissect Antifungal Drug Resistance in the Fungal “Superbug” Candidozyma auris at University of Aberdeen , listed on FindAPhD.com
findaphd.com
OK Pinterest, I see where you are coming from
