Excited to share our work: Subtype-resolved norepinephrine imaging with an engineered α1D-adrenergic receptor indicator: Cell Reports Methods www.cell.com/cell-reports...

Subtype-resolved norepinephrine imaging with an engineered α1D-adrenergic receptor indicator

Rohner et al. develop Alpha1DLight, an α1D-adrenergic receptor-derived fluorescent indicator that enables subtype-resolved norepinephrine imaging. The sensor shows high affinity, reversible responses,...

cell.com

#FENS2026 – Friday 11:30–13:00. Paul Lamothe-Molina @neuronblaze presents nLightG2/nLightR2, next-gen norepinephrine sensors for in vivo use. Come by to talk GPCR indicators, photometry, 2P imaging, multiplexing, or troubleshooting. Poster PS07-10AM-018. Paper: doi.org/10.1038/s415... @PatriarchiLab

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods

Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

doi.org

This is an impressive milestone!

Wei-Chung Allen Lee@darbly.bsky.social · 2mo ago

Now published - the #BANC! A full central nervous system (CNS) connectome of a limbed animal at single-synapse resolution, enabling us to follow sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS. #neuroscience. Video by @quorumetrix.bsky.social 1/18

The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot doi.org/10.7554/eLif... Great work by @labouessemarie.bsky.social and her student Alina! Congrats

The nucleus accumbens shell regulates hedonic feeding via a rostral hotspot

Within the nucleus accumbens shell, a spatially defined rostral subregion selectively modulates hedonic feeding, revealing functional heterogeneity in reward circuitry underlying food consumption.

doi.org

Hello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...

Neuropixels + Optogenetics = Neuropixels Opto Combining high-resolution electrophysiology and optogenetics. 960 sites, 28 emitters, 2 colors. Today in @natmethods.nature.com doi.org/10.1038/s415... Thanks to @wellcometrust.bsky.social, @alleninstitute.org, @hhmijanelia.bsky.social & team.

Out today in @natneuro.nature.com What started as a great discussion at an amazing meeting organized by @joaofoliveira.bsky.social culminated in our new Perspective on how #astrocyte functions operate across multiple spatial scales. Read: rdcu.be/fk0B7 Full text: www.nature.com/articles/s41...

The multiple scales of astrocytic functional units

Nature Neuroscience - Astrocytes modulate complex brain functions. These ubiquitous glial cells constitute a multilayered system of functional units that operate across multiple spatial scales,...

rdcu.be

Absolutely stunning work: de novo designed miniproteins targeting GPCRs as potent agonists and antagonists. This opens countless possibilities for programmable signaling, cleaner therapeutics, and faster drug discovery. Protein design is coming for pharmacology. 🚀 doi.org/10.1038/s415...

Very cool to see the power of de novo design applied to dye-labeling!

HHMI@hhmi-science.bsky.social · 3mo ago

Meet NovoTags, a new class of fluorescent imaging probes that combines AI-driven protein design from #HHMIInvestigator David Baker w/ ultra-bright dyes from Janelia’s Luke Lavis, enabling scientists to watch dozens of proteins inside a cell at once — something current tools can't do: bit.ly/4noBb06

🚨Exiting new preprint from Lerner Lab postdoc AJ Miller-Hansen examining the thalamus as a physiological driver of local, acetylcholine-dependent dopamine release! 🚨 DA-ACh interactions have been 🔥but what’s really going on in vivo? We think we have some answers. #neuroskyence🧪

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 3mo ago

Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum https://www.biorxiv.org/content/10.64898/2026.05.08.723861v1

Check out the birghtest star in the room: PinkyCaMP - the latest member to the red GECI family! Amazing work led by Olivia Masseck and a wonderful team! Proud to contribute

Ryan Fink@finkryan.bsky.social · 3mo ago

PinkyCaMP is finally published!! My first paper co-first authored with @sikmys.bsky.social where we make a great optogenetic and multiplex compatible red calcium indicator. Thank you to @massecklab.bsky.social and @campbell-lab.bsky.social for guiding this journey www.nature.com/articles/s41...

Amazing piece on Locus Coeruleus neurons! Great work

Jeremiah Cohen@jeremiahycohen.bsky.social · 4mo ago

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

This will be a great conference!

WilluhnLab@willuhnlab.bsky.social · 4mo ago

Submit your abstract until May 15 for the "Monitoring Molecules in Neuroscience" conference in Amsterdam (Sept 7-10, 2026) to get the latest update on in-vivo neuro-methods from a brilliant lineup of keynote and panel speakers: monitoringmolecules.org/invited-spea... Please repost!

Wait… localized norepinephrine transients in the awake visual cortex?! Who would have guessed this neuromodulatory signal is that spatially precise, right where visual processing is happening. Brain state control just got a lot more local. @ruedigersarah.bsky.social www.nature.com/articles/s41...

Wow - this is really amazing work, congrats to the whole team!

Lin Tian, PhD@lintianphd.bsky.social · 4mo ago

Nikki Tjahjono’s PhD work is out as a @cellpress.bsky.social preview in @ssrn.bsky.social! With @isacofflab.bsky.social, we introduce iHaloGluSnFR, the first red-shifted chemigenetic glutamate sensors, optimized for simultaneous imaging with neuromodulators. papers.ssrn.com/sol3/papers....

Nikki Tjahjono’s PhD work is out as a @cellpress.bsky.social preview in @ssrn.bsky.social! With @isacofflab.bsky.social, we introduce iHaloGluSnFR, the first red-shifted chemigenetic glutamate sensors, optimized for simultaneous imaging with neuromodulators. papers.ssrn.com/sol3/papers....

Norepinephrine imaging, pushed further. Our latest NE sensors enable highly sensitive monitoring across recording modalities, Have you been using GRABNE2 sensors? the toolkit just got a major upgrade. Interested in trying them in your system? Reach out.

Improved red and green indicators for norepinephrine detect norepinephrine release in awake behaving mice. @tpatriarchi.bsky.social www.nature.com/articles/s41...

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods

Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

nature.com

The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...

Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods

Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

doi.org

Feels like a pivotal moment. The president is screening a movie about his third wife and crying about a lawsuit challenging his guilded ballroom, while good-hearted Americans looking out for their neighbor are getting murdered by state police. Will Americans finally wake up?

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function. This was a really fun collaboration with @miriamstoeber.bsky.social and @amanglik.bsky.social labs, check it out! www.biorxiv.org/content/10.6...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains. Is it impressive? Yes Is it new? No Should you use it? Probably not. www.cell.com/cell/fulltex...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains

A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...

cell.com

Congrats Martin, great work!

Martin Pacesa@martinpacesa.bsky.social · 11mo ago

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.

Praneel Sunkavalli@praneelsunkavalli.bsky.social · last yr.

I am excited to share our preprint on how hypothalamic dopamine neurons govern slow changes in motivation over days! Below are our findings: www.biorxiv.org/content/10.1...

#BlueskyResistance #Voices4Victory #ProudBlur Advertisement at a London bus stop. Ya gotta love the British…

www.nature.com/articles/s41... This study is absolutely mind-blowing.

Topological segregation of stress sensors along the gut crypt–villus axis - Nature

Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of t...

nature.com

Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!

Tal Laviv@lavivtal.bsky.social · last yr.

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!