A multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals presented in Nature Medicine identifies 26 risk loci for fibromyalgia, including HTT, and finds genetic correlations with chronic pain and psychiatric and somatic disorders. go.nature.com/4q860Yp 🧬🧪

#BGA26 was a blast! Happy to have had the opportunity to present my work in Amsterdam and share one of my favorite research topics. Thanks to @lydiarader.bsky.social, @tabeasch.bsky.social, and @evangiangrande.bsky.social for such a great discussion and for their amazing talks!

Original: Drs. @lydiarader.bsky.social, @dangustavson.bsky.social, @torwager.bsky.social, & coll. used mixed-effects models to examine associations between polygenic scores and adolescent self-reported pain presence, intensity, recurrence, and multi-site pain. FULL: www.jpain.org/article/S152...

Adolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD study

Adolescent pain complaints may be related to genetic risk for chronic pain across the life course. Identifying whether adolescent pain is genetically linked to chronic pain in adulthood can advance…

jpain.org

What if some adolescent pain complaints are early manifestations of lifelong chronic pain risk? www.jpain.org/article/S152...

Adolescent pain reports share genetic overlap with adult chronic pain conditions: A polygenic score analysis using the ABCD study

Adolescent pain complaints may be related to genetic risk for chronic pain across the life course. Identifying whether adolescent pain is genetically linked to chronic pain in adulthood can advance un...

jpain.org

So much for "sex, drugs, and rock n' roll". A new paper by Dr. Lydia Rader shows that adolescent music engagement is related to less alcohol use & substance use experimentation 5-11 years later through protective environmental factors. @lydiarader.bsky.social pmc.ncbi.nlm.nih.gov/articles/PMC...

Adolescent Music Engagement is Associated with Less Alcohol Consumption and Substance Experimentation 5 to 11 Years Later: A Genetically Informative Study

Adolescence is a critical developmental window for shaping substance use trajectories. Music engagement during this period may reduce substance experimentation and later misuse through direct effects ...

pmc.ncbi.nlm.nih.gov

New paper! 🎶🎸 • Do adolescents who engage in music use less substances later in development? • Are the links direct effects or due to shared genetic/environmental influences? • Is music constructive for youth at high genetic risk for substance use? Paper link: www.researchgate.net/publication/...

(PDF) Adolescent Music Engagement Is Associated With Less Alcohol Consumption and Substance Experimentation 5–11 Years Later: A Genetically Informative Study

PDF | Objective: Adolescence is a critical developmental window for shaping substance use trajectories. Music engagement during this period may reduce... | Find, read and cite all the research you nee...

researchgate.net

New preprint alert! 🚨 Building on exciting new work in autism subtyping, we investigated how biological sex 👭 and age at diagnosis 👵 shape the genetic landscape of autism. 🧬 Check out our findings below 🧵 and the full paper here: www.researchsquare.com/article/rs-9...

There was a lot of laughter during this conversation and a few secret confessions... But we also had some great discussions about musicality, genetics, Beethoven and public outreach, mental health, and music genres... Thank you @rafaelahlskog.bsky.social and @aysuo.bsky.social for having me! 🎶

ESSGN@essgn.bsky.social · 3mo ago

What's the deal with musicality and genetics? This week, Born and Raised went to talk to Laura Wesseldijk. There's something here for both metalheads, horse riding enthusiasts and trombonists!

Yuan et al. show that neuropathic chronic low-back pain has distinct thalamic brain changes compared to non-neuropathic low-back pain, underscoring the need to distinguish between these phenotypes to reduce heterogeneity in future studies #PAIN bit.ly/4msHe3i

New Scientific Reports article lead by IBG graduate student @eamonnduffy.bsky.social and faculty member Marissa Ehringer finds genetically divergent rat strains differ in oxycodone self-administration and effects on gut microbiome. Congrats to the team on this work! www.nature.com/articles/s41...

Oxycodone self-administration and genetic background exert community-specific effects in the gut microbiome - Scientific Reports

The gut microbiome and genetic factors contribute to several opioid-related phenotypes in humans and animal models. Here, we examined the effects of genetic background and oxycodone self-administratio...

nature.com

New Nature Communications paper from IBG graduate student Jeremy Lawrence describes high genetic overlap across 73 physical illnesses (e.g., cancers, heart failure, pneumonia) and internalizing, substance use, and neurodevelopment disorders.🧬 www.nature.com/articles/s41...

Original: Tacugue, Dr. Kossowsky et al. ( @bostonchildrens.bsky.social) found that chronic pain doesn't just hurt, it impairs memory & attention in adolescents —4 weeks of intensive rehab improved cognition, sleep & mental health Full: www.jpain.org/article/S152...

Assessing relationships between cognition, sleep, and mental health in pediatric patients with chronic pain

Chronic pain in adolescents commonly disrupts cognitive functioning, sleep, and mental health. Research suggests underdeveloped cognitive skills in adolescents may lead to poor self-management thus…

jpain.org

New article published in Addiction and lead by IBG postdoc @lydiarader.bsky.social identifies transdiagnostic genetic overlap between general chronic pain and addiction risk, along with substance-specific pathways. doi.org/10.1111/add....

Genetic overlap of chronic pain, musculoskeletal‐specific pain, substance use disorders and substance use consumption: Common addiction and substance‐specific effects

Background and aims Chronic pain and substance use disorders frequently co-occur and may share general addiction-related and substance-specific genetic pathways. Additionally, substance consumption ...

doi.org

Check out our new paper! We found general chronic pain is genetically linked to broad addiction liability, while musculoskeletal pain shows more substance-specific genetic associations, particularly with tobacco and alcohol use. Link: onlinelibrary.wiley.com/share/author...