Another fantastic milestone for rare glomerular diseases! What an impressive momentum in kidney therapeutics and the rare disease community #raredisease #glomerulardisease #nephSky #FSGS

International Society of Glomerular Disease@isgd.bsky.social · 6mo ago

More than 100 years after #FSGS was first described, we have the first FDA-approved treatment. A proud day for the collaborative #ParasolProject! With the global community uniting to transform glomerular health, this is only the beginning. ⛱️

Today is #C3GAwarenessDay! At ISGD, we stand with people living with this rare kidney disease. As a medical society for #GlomerularDisease experts, we're committed to raising awareness and moving the science forward to bring more hope and solutions to the C3G community. #C3G #ISGD

This is so shameful…

The Lancet@thelancet.com · last yr.

After revoking contested appointments to Italy's National Immunization Technical Advisory Group, experts warn the episode signals wider risks for evidence-based policy and Italy's role in global health. Find out more in a new World Report: tinyurl.com/3j6md7tn

Fresh online on @natcomms.nature.com ! Great collaboration with the lead team at GharaviLab / CPMG. Large exome-wide analysis that points to many findings, including two novel genes: ARID3A and NR6A1. #CAKUT #humangenetics #development #pediatrics #NephSky #SkyNeph www.nature.com/articles/s41...

Exome analysis links kidney malformations to developmental disorders and reveals causal genes - Nature Communications

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, alon...

nature.com

Wow! Second approved drug for an ultrarare disease in a few months, and with broader indication. What a milestone! Time for EMA’s approval now. #raredisease #glomerulardisease #c3g #nephSky

Nephrology Times@nephtimes.bsky.social · last yr.

⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...

Very remarkable long-term outcomes and safety profile for one of the first mAbs ever used in glomerular diseases #glomerulardiseases #rarediseases #nephSky

@kireports.bsky.social · last yr.

Long-term Outcome of #Adult Patients With #Membranous Nephropathy Treated With #Rituximab #VisualAbstract by @priti899.bsky.social www.kireports.org/ar...

To do or not to do—genetic testing for autosomal dominant polycystic kidney disease in children and adolescents doi.org/10.1016/j.kint.2025.05.001 Original article: doi.org/10.1016/j.kint.2025.02.026 #KICommentary #NephSky #MedSky #ADPKD

Today’s Daily Cartoon, by Paul Noth. #NewYorkerCartoons Sign up for our humor newsletter to never miss a Daily Cartoon: nyer.cm/kyxchAh

President Trump claims the US strike on Iran was a "spectacular military success." We'll see. What we do know is that Trump has pushed the US into a new war in the Middle East with considerable risks of escalation. Here are the risks I'm concerned about: www.nytimes.com/2025/06/22/o...

Kidney health finally prioritized in the WHO noncommunicable disease agenda! #kidneyhealthmatters #nephsky #medsky

ISNkidneycare@theisn.org · last yr.

🌍 History made! For the first time, kidney care is on the global health agenda. #WHA78 adopted a landmark resolution recognizing kidney health in the fight against #NCDs. 👏 Thanks to Guatemala and the global kidney community for making this possible! #KidneyHealthMatters

In a new publication, Drs. Steers, Gharavi and colleagues performed genetic and immunological studies of IgA nephropathy and demonstrated a new role of aberrant O-glycosylation in the pathogenesis of IgA Nephropathy. Read more here: www.jci.org/articles/vie...

Increased risk of developing #kidneydisease in offspring exposed to maternal preeclampsia independently from preterm birth? #nephsky #medsky

Kidney International@kidneyint.bsky.social · last yr.

A nationwide register-based cohort study examined the association between #preeclampsia in mothers and the risk of #kidneydisease in their offspring doi.org/10.1016/j.kint.2025.04.017 #OpenAccess #chronickidneydisease #CKD #Glomerulonephritis #PedsNeph #NephSky #MedSky #diabeticnephropathy

Scientific progress grows out of freedom. As a society, we must stand with scientists and speak out against restrictions on scientific freedom and funding - we are all in this together. www.nature.com/articles/d41... www.science.org/content/arti...

US researchers must stand up to protect freedoms, not just funding

Curtailment of freedoms and disregard for the rule of law in the United States is destroying the ability of science to serve the nation’s, and the world’s, interests. Researchers can take action.

nature.com

Jarcy Zee@jarcyzphd.bsky.social · last yr.

A call to action for researchers to advocate not only for funding but to put pressure on universities, professional societies, and government representatives to protect academic freedom, international scholars, and science as a whole: rdcu.be/elOdv

Alternative complement pathway dysregulation in CKD and CKD progression, endothelial inflammation and cardiovascular outcomes… room for complement inhibitors beyond complement-mediated kidney diseases? www.jci.org/articles/vie... #NephSky #MedSky

Journal of Clinical Investigation@jci.org · last yr.

Aberrant activation of complement's alternative pathway may be the missing link in understanding how vascular and systemic inflammation accelerates chronic kidney disease progression. Read more in the review by Jalal, Thurman & Smith: buff.ly/DwHd0ut

Hey I know these people! Check out this paper👇

American Journal of Kidney Diseases@ajkd.bsky.social · last yr.

Glucocorticoid Exposure and Infection in Children and Adults With Glomerular Disease: Findings From the Cure Glomerulonephropathy Study bit.ly/3DHbXai (FREE)

After Trump’s first 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding.

NIH insiders: Trump is ‘dismantling and destroying everything'

After just 100 days, agency scientists say U.S. health institutes are demoralized and have lost essential staff and funding

scim.ag

100-day mark and 1361 to go… www.nytimes.com/interactive/...

How Trump’s Second Term Is Changing Power, Institutions and More (Gift Article)

President Trump has wielded the presidency as an instrument of blunt power, ignoring the howls of outrage from Democrats and daring largely docile Republicans to challenge the limits of his authority.

nytimes.com

#handsoff

Mor Naaman@informor.bsky.social · last yr.

I have never seen anything like this in NYC. 5th Ave covered from 42nd St well to the 20s. Nobody prepared for this volume. Volunteers are holding the traffic on all the side streets. No police in sight. #handsoff

Public health, biomedical science, and the well being of Americans will be worse off for this week's devastating cuts at HHS. My latest for @opinion.bloomberg.com (gift link):

This Isn’t How You Make America Healthy Again

Gutting the public health agencies that keep Americans safe — and not being transparent about it — will cause harm that can’t easily be reversed.

bloomberg.com

"The strategy of not speaking up out of fear is not working" @lisamjarvis.bsky.social calls Big pharma to mobilize and support federally funded research and drug evaluation - both engines of most innovation biotech and pharma companies develop.

Lisa Jarvis@lisamjarvis.bsky.social · 2y ago

Noticeably silent amid the upheaval at HHS? Big pharma. Every new drug has NIH somewhere in its DNA--and NIH funding supports the training of their workforce. Now they're finding out FDA isn't safe, either. Wrote about how keeping quiet isn't working My latest @opinion.bloomberg.com (gift link):

Finally, top scientists speak up against the Trump administration in a letter signed by 2,000 elected members of the National Academies of Sciences, Engineering, and Medicine: "the nation's scientific enterprise is being decimated"; see related NYT coverage here: www.nytimes.com/2025/03/31/s...

Beautiful, mechanistic work! Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy www.jci.org/articles/vie...

Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. www.sciencedirect.com/science/arti...

Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model.

Human kidney organoids derived from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) have become novel tools for studying various…

sciencedirect.com

Columbia's "IgA Nephropathy Diagnosis & Treatment Updates 2025" on April 4th. All the latest IgAN updates in one place with outstanding speakers! @cuimcglomcenter.bsky.social @cuimcmedicinedept.bsky.social @jradnephro.bsky.social @kirylukk.bsky.social #Nephsky #glomerulardisease

David Koch Jr. Glomerular Kidney Center@cuimcglomcenter.bsky.social · 2y ago

Happy Thursday! Around two weeks left to register for the IgAN Diagnosis & Treatment Updates 2025 on April 4th. Feel free to register using the following link: www.eventleaf.com/e/...

NEW editorial on what public health means under Trump 2.0 At The Lancet Public Health, it still means to stand for the communities we serve, to report, document, support researchers and practitioners, and advocate for better health for ALL. Read #openaccess www.thelancet.com/journals/lan...

Public health under Trump 2.0: the first 50 days

Jan 20, 2025, US President Donald Trump took charge of the Oval Office and began by signing an array of executive orders spanning from withdrawal from WHO and the Paris Climate Agreement to freezing t...

thelancet.com

What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy #MedSky

How collection of broad family history from CKD patients improve clinical risk stratification. Proud to be part of this. Thanks to Francesca Zanoni, @kirylukk.bsky.social #CureGN #CRIC #NephSky

ASN Publications@asnpublications.bsky.social · 2y ago

Broad collection of family history in context of CKD improved clinical risk stratification. Family history of diabetes associated with higher risk of CKD progression independent of diabetes status or polygenic risk score for diabetes in cohorts. https://bit.ly/JASN0653 @madmarasa.bsky.social

Nice to see this in print - combined analysis of #CureGN and #CRIC demonstrates the value of broad family history collection from patients with various forms of CKD. Interestingly, positive family history of diabetes was associated with a higher risk of CKD progression even in non-diabetics!

ASN Publications@asnpublications.bsky.social · 2y ago

Broad collection of family history in context of CKD improved clinical risk stratification. Family history of diabetes associated with higher risk of CKD progression independent of diabetes status or polygenic risk score for diabetes in cohorts. https://bit.ly/JASN0653 @madmarasa.bsky.social

Emerging role of genetics🧬 in #kidneytransplantation doi.org/10.1016/j.kint.2024.09.026 #KIMiniReview #ChronicKidneyDisease #CKD #genetickidneydisease #NephSky #MedSky

Combined PLA2R-Ab testing with ELISA and IIF provided optimal test characteristics in making a non-invasive diagnosis of MN before or soon after kidney biopsy. Further studies needed to assess whether genetic data can augment this approach. bit.ly/CJASN0671 #ASNCJASN @jarcyzphd.bsky.social