Uri Manor
@manorlaboratory.bsky.social
Ass. Prof & Director Goeddel Family Technology Sandbox; CZI Imaging Scientist; Hard-of-hearing; Follows≠endorse; ❤️ organelles/deep-learning/cochlea/neurons
I think this article is brilliantly written and made me laugh out loud a few times. The very real challenge of separating hype from reality exists on both ends of the dystopia-utopia spectrum. harpers.org/archive/2026...
Child’s Play, by Sam Kriss
Tech’s new generation and the end of thinking
harpers.org
A fun (AI-enhanced) image of 12187 ABR waveforms. We used these data from our own lab and several others to train ABRA (PMID: 38948763) and are still using it to train next-gen machine learning models for cochlear studies. Stay tuned (no pun intended) for more!
Open-source, deep learning-based tool VASCilia enables rapid quantification & characterisation of stereocilia – advances capabilities in hearing research 📷 Yasmin M. Kassim et al @manorlaboratory.bsky.social @ucsandiego.bsky.social in @plosbiology.org ➡️ bpod.org.uk/archive/2026...
BPoD | Seeing Sound Sensors
Seeing Sound Sensors - Biomedical pictures for February 2026.
bpod.org.uk
As Fran was nice enough to highlight this, I thought I'd put up a brief thread. 3 in 10 proteins that our cells make are either embedded in membranes (ion channels, adhesion molecules, etc.) or secreted (insulin, antibodies). They move through the secretory pathway. 1/
Fran Bottanelli@franbottanelli.bsky.social · 6mo agoExciting preprint from the @merz.bsky.social lab proposing how fidelity of membrane fusion is achieved #membranes #trafficking
🚀 Registration is NOW OPEN for AIMS 2026! Join us at UC San Diego for the premier workshop on AI for Multimodal Science. Secure your spot (Deadline March 7): 👉 Register: tinyurl.com/AIMS2026 🔗 Website: aims-2026.vercel.app
AIMS 2026: AI for Multimodal Science Registration
Register for the AIMS 2026 workshop, sponsored by Schmidt Sciences, exploring the latest advancements in Artificial Intelligence for Multimodal Science. Time: June 23–25, 2026 Location: Seventh Colle...
tinyurl.com
Press release on our paper: today.ucsd.edu/story/new-ai...
New AI Tool Accelerates Hearing Research with Unprecedented 3D Views of Sensory Cells
Scientists have developed a 3D, AI-based tool for viewing hearing cells. To understand hearing damage from noise and aging, and develop new treatments, scientists need detailed images of hair cells. T...
today.ucsd.edu
Uri Manor@manorlaboratory.bsky.social · 7mo agoSo excited to see Yasmin’s beautiful paper is finally out! We hope this tool will be useful for everyone studying stereocilia bundles (including companies developing gene therapies). I fantasized about having an AI tool like this when I was a grad student. All the code and data is open source.
Does anyone understand how the AC meeting is literally the day after Study Section? Don't they need summary statements for this? I have been refreshing my commons page every minute to see if there is a score/summary statement, but in reality this would be unprecedented speed? What am I missing?
So excited to see Yasmin’s beautiful paper is finally out! We hope this tool will be useful for everyone studying stereocilia bundles (including companies developing gene therapies). I fantasized about having an AI tool like this when I was a grad student. All the code and data is open source.
PLOS Biology@plosbiology.org · 7mo agoCochlear hair cell #stereocilia bundles are vital for hearing, but what is their 3D morphology? @manorlaboratory.bsky.social present VASCilia, a tool that automates analysis of 3D #ConfocalMicroscopy datasets of phalloidin-stained #CochlearHairCell bundles @plosbiology.org 🧪 plos.io/3NSHdYW
Cochlear hair cell #stereocilia bundles are vital for hearing, but what is their 3D morphology? @manorlaboratory.bsky.social present VASCilia, a tool that automates analysis of 3D #ConfocalMicroscopy datasets of phalloidin-stained #CochlearHairCell bundles @plosbiology.org 🧪 plos.io/3NSHdYW
It took me >3 hours to update my @NIH ScienCV biosketch to meet new formatting requirements. These formats are often updated, forcing every one of ~45,000 NIH PI's to spend time on this. Assuming *minimum wage* ~$20/hour and my experience was average, this amounts to $3M/update.
a poster that says ' your tax dollars hard at work '
ALT: a poster that says ' your tax dollars hard at work '
media.tenor.com
I'm so happy to have gotten the opportunity to work on this project and I'm SO excited that they selected our image for the cover!
Ricardo D. Righetto@lifeonthewedge.bsky.social · 7mo agoThis one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]
The original proposal's critique scores. I don't know how we are supposed to succeed in such a capricious system.
Uri Manor@manorlaboratory.bsky.social · 7mo agoInitial submission of a grant received a 15%-ile score. But we had to submit as new since the PAR expired. We submitted an even stronger, but just slightly modified version to address any/all weaknesses in the prior summary statement. Just found out it was "Not Discussed"😱
Emotional - Uri Manor @manorlaboratory.bsky.social was so wonderfully open & an inspiration to listen on #TheMicroscopists Uri talks about growing up with hearing loss & a winding path through baseball-music-restaurant work led him to physics & then biology - pls share Stream bit.ly/microscopist...
The Microscopists | Uri Manor (UC San Diego School of Biological Sciences)
In this episode of The Microscopists, Uri Manor, Assistant Professor of UCSD, opens up about growing up with profound hearing loss and how, despite wanting nothing to do with becoming a scientist, ...
bit.ly
Initial submission of a grant received a 15%-ile score. But we had to submit as new since the PAR expired. We submitted an even stronger, but just slightly modified version to address any/all weaknesses in the prior summary statement. Just found out it was "Not Discussed"😱
Can someone please connect me with someone at FDA CDER (or with expertise thereof) to discuss the pathway to approval for n-of-1 & n-of-many ASOs? I've got some pretty technical questions too involved to describe here.
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 163 at CellBio2025 Sunday Dec 7, I present work by Hiro Ishikawa using a synthetic biology approach to test a length-sensing model based on diffusion of kinesin in flagella
Flagellar length control in Chlamydomonas is a paradigm for organelle size regulation. In poster 155 at the CellBio2025 meeting Sunday Dec 7, Ximena Garcia Arceo uses Lithium, which increases intraflagellar transport, as a tool to probe how length-altering mutants work.
Best email I ever got after a talk 🥹🥹🥹
Uri Manor@manorlaboratory.bsky.social · 8mo agoMy tenure talk is tomorrow 😅😅😅😅😅
Omg this is amazing. Fun fact: my original PhD goal was to study magnetoreception but no PIs were interested and someone suggested I study hair cells as an analogous system. Turns out they were even more analogous than we imagined!!! www.science.org/doi/10.1126/...
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
science.org
A holiday demonstration of the different penetration depths of red and blue light into tissue. #optics
Attempt number seven at uploading this video of intermediate filaments in an enormous COS7 cell. I have a feeling the BlueSky compression will not do it any favors.
As someone with Connexin-26 (GJB2) mutations, I've managed to so far study most forms of hearing loss that do NOT involve GJB2. As a cell biologist, I've managed to study ER-organelle related processes and disorders with minimal connection to hearing loss. Now this paper drops.
Looking forward to some "inner ear evangelism" in ~30 minutes (signup link in comments)
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
biochem.weill.cornell.edu
Following this pattern I’ve been able to write a set of skills that turns Claude Code into a scientific literature searching tool, compiling lists of relevant papers. I’ll make it public after some more work.
Kurt Thorn@kurtthorn.bsky.social · 10mo agoThis is a really inspirational way to work with Claude Code
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
