1/13 How many calories does it take to build 1 kg of muscle? The question is straightforward but, as far as we can tell, it has not yet been answered quantitatively. www.biorxiv.org/content/10.6...

The Energetic Cost of Building Human Skeletal Muscle

The energetic cost of building human skeletal muscle has never been explicitly calculated or measured. We developed a quantitative bottom-up accounting model that integrates human skeletal-muscle comp...

biorxiv.org

🚨 Our new meta-analysis is out in Journal of Sports Sciences! We reviewed 40 studies comparing semitendinosus vs. biceps femoris activation during hamstring strengthening exercises (knee vs hip based). doi.org/10.1080/0264... Here's what we found 🧵👇 #hamstrings

As another alternative to the standard forest plot for visualizing many effect size estimates in a meta-analysis, one can use 'orchard plots' (Nakagawa et al., 2021). Example code to create such figures can be found here: www.metafor-project.org/doku.php/plo... #MetaAnalysis #RStats

When vitamin C levels are low, correcting them makes sense. But in this study, we found no evidence that each person needs a personalized vitamin C supplementation.

Nikos Margaritelis@margaritelis.bsky.social · 4mo ago

Happy to share our publication in FRBM. We used aggregated sets of n-of-1 trials to study individual oxidative stress & inflammation responses to vit C supplementation. Huge thanks to @lorenzololli.bsky.social @gregatki.bsky.social @mg-nikolaidis.bsky.social www.sciencedirect.com/science/arti...

Happy to share our publication in FRBM. We used aggregated sets of n-of-1 trials to study individual oxidative stress & inflammation responses to vit C supplementation. Huge thanks to @lorenzololli.bsky.social @gregatki.bsky.social @mg-nikolaidis.bsky.social www.sciencedirect.com/science/arti...

Individual oxidative stress and inflammation responses to vitamin C supplementation: Aggregated sets of n-of-1 trials

Personalized antioxidant supplementation is promoted to optimize redox balance and inflammation profile.To quantify the short-term effects of vitamin …

sciencedirect.com

Our new paper with @mg-nikolaidis.bsky.social out in @cp-trendsmolecmed.bsky.social “Science captured by storytelling: the oxidative stress narrative” DOI: authors.elsevier.com/a/1lt2w5Eb1B...

🚨LEAD FEATURE ARTICLE🚨 November 2025✨ We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.

It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...

This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...

2nd Redox Medicine Workshop ... Meet the Speakers: More info: redoxmedicine2025.febsevents.org Important dates: July 1 - SFRR-E and FEBS Fellowships Applications; July 20 - Abstract Submission (General Track) @sfrre-ecr.bsky.social @ucoimbra.bsky.social @febsjuniorsection.bsky.social

I'm grateful to the SFRR-E for the ECR Fellowship (@sfrre-ecr.bsky.social) which made the RedoxOne project a reality. Otherwise, it would still be an idea saved in the “future studies” word file! #redox #antioxidants #exercise #nutrition #Nof1 #interindividual_variability #galway

Vitamin C+E supplementation blunts molecular adaptations to sprint interval training but not performance gains. Since performance wasn’t impaired, I wonder whether, and to what extent, the blunted molecular responses can truly be considered detrimental physoc.onlinelibrary.wiley.com/doi/10.1113/...

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

Abstract figure legend Sprint interval training (SIT) is a popular time-efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all-out cycling sprints) over 3...

physoc.onlinelibrary.wiley.com

After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...

There's a nice discussion at Frank Harrell's datamethods: discourse.datamethods.org/t/dichotomiz...

Dichotomization

I’m writing a paper about “An Empirical Assessment of the Cost of Dichotomization” together with Frank Harrell (@f2harrell) and Stephen Senn (@Stephen). In this paper, we quantify the information loss...

discourse.datamethods.org

Join us for a special ECR SFRR Webinar focused on Mental Health in Research by Amal Ibrahim. Date: Tuesday 6th May 2025 Time: 15:00 CET Where: Online (link in bio) #MentalHealthInScience #ECRSFRR #WellbeingInResearch #FreeRadicalResearch #AcademicLife #PhDlife #PostdocLife #ScienceCommunity

Hats off to them for publishing that paper without mentioning n-of-1 trials or person-by-treatment interactions 😬. We've this paper currently under review. It's frustratingly long-winded, but that's the complex nature of the precision nutrition beast I suppose, osf.io/preprints/os...

James Imlay turns redox chaos into clockwork: his new paper shows how membrane permeability sets the tempo of oxidative stress, with straight-up back-of-the-envelope math in the appendix. Fundamental, elegant, causal. onlinelibrary.wiley.com/doi/10.1111/...

The Barrier Properties of Biological Membranes Dictate How Cells Experience Oxidative Stress

Molecular oxygen diffuses across membranes with such speed that, despite respiration, the intracellular oxygen concentration does not differ significantly from that outside the cell. In contrast, mem...

onlinelibrary.wiley.com

📢 Exciting Webinar Alert! Join us tomorrow, April 1st, at 15:00 CET for an unmissable webinar on chaperones in redox biology, hosted by @sfrre-ecr.bsky.social! We’re thrilled to welcome two fantastic speakers: @ulrichlab.bsky.social and @rsutandy.bsky.social. See you there!

Good to see this paper finally published in EJON, after a strange prior experience with another journal, "Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial" link.springer.com/article/10.1...

Inter-individual differences in the blood pressure lowering effects of dietary nitrate: a randomised double-blind placebo-controlled replicate crossover trial - European Journal of Nutrition

Purpose Dietary nitrate supplementation increases nitric oxide (NO) bioavailability and reduces blood pressure (BP). Inter-individual differences in these responses are suspected but have not been inv...

link.springer.com

Study shows that chronic antioxidant supplementation (VitC+VitE) blunted molecular adaptations to training, yet, no impact on any measure of exercise performance—considering that "antioxidant" is a vague term and that VitC+VitE may not always act as such. www.biorxiv.org/content/10.1...

Great redox researcher to follow and excellent review in the redox biosensors field!

Brandán Pedre@brandanium.bsky.social · 2y ago

First Bluesky post! 👋 I work designing fluorescent indicators for redox biology. Last year, I published a review on genetically-encoded redox biosensors—DM me if you’d like a copy! Happy to connect with fluorescence enthusiasts and redox biologists. #FluorescenceFriday doi.org/10.1016/j.ab...

Important study highlighting plausible molecular links between redox metabolism and exercise performance—an area notoriously difficult to dissect. The findings challenge assumptions that G6PD deficiency decreases exercise performance. A human replication study would be invaluable.

Angelo D’Alessandro@dalessandrolab.bsky.social · 2y ago

G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social ashpublications.org/bloodadvance...

G6PD deficiency affects 6% of humankind, predisposing RBCs to hemolysis after oxidant stress. Unexpectedly, humanized G6PD deficient mice do not hemolyze after oxidant stress post exercise, and tolerate exercise better! On the cover of @bloodadvances.bsky.social ashpublications.org/bloodadvance...

Increased exercise tolerance in humanized G6PD-deficient mice

Key PointsG6PD-deficient mice maintain higher exercise speeds without increased red blood cell hemolysis, questioning assumed risks.Increased cardiac outpu

ashpublications.org

Our contribution to the Special Issue "Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance" in FRBM, Guest-edited by Prof. Gomez-Cabrera & @c-handschin.bsky.social #redox #supplements #sports #evidence

Christoph Handschin@c-handschin.bsky.social · 2y ago

“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues. www.sciencedirect.com/science/arti... 10/17

“Evidence-based sports supplements: A redox analysis” by @margaritelis.bsky.social, @parikki.bsky.social, @mg-nikolaidis.bsky.social and colleagues. www.sciencedirect.com/science/arti... 10/17

Evidence-based sports supplements: A redox analysis

Despite the overwhelming number of sports supplements on the market, only seven are currently recognized as effective. Biological functions are largel…

sciencedirect.com

“Unlocking Athletic Potential: Exploring Exercise Physiology from Mechanisms to Performance” in FRBM is complete! Reviews on exercise physiology, muscle plasticity, molecular mechanisms and more! All #openaccess! #myoblue #muscle #exercise www.sciencedirect.com/special-issu... A long🧵: 1/17

The editorial mentoring programme of the @sfrre-ecr.bsky.social is now running! Seeing initiatives we envisioned coming to fruition is always quite emotional! Wishing the best of success to the mentees for their journey ahead! Many thanks to senior editors of Redox Biology, FRBM and RBC, &elsevier!

New preprint: “Three-Sided Testing to Establish Practical Significance: A Tutorial” (osf.io/preprints/ps...) with @FitzgeraldJack_, proposing an upgraded version of the TOST equivalence test 🧵