Tessera

@marialukarska.bsky.social

Our ProteinGuide paper is finally out! Thanks to all the co-authors @junhaobearxiong.bsky.social, @ishangaur.bsky.social, @hnisonoff.bsky.social, @loltrogge.bsky.social, @jlistgarten.bsky.social, @savagecatsonly.bsky.social! @innovativegenomics.bsky.social www.nature.com/articles/s41...

Property guidance for protein sequence generative models with ProteinGuide - Nature Biotechnology

On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.

nature.com

@marialukarska.bsky.social · 3w ago

I’m happy to share our pre-print exploring the activity and specificity trade-offs in adenine base editors. Thanks to my amazing co-authors Luke Oltrogge, @hnisonoff.bsky.social, and all the other contributors @jlistgarten.bsky.social @savagecatsonly.bsky.social @innovativegenomics.bsky.social 🧵1/7

Activity and specificity trade-offs in adenine base editors

Adenine base editors (ABEs) are CRISPR effectors that introduce A-T to G-C transitions in the genome using a nucleotide deaminase fused to a Cas protein. ABEs have been evolved to have very high editi...

biorxiv.org

Nature Biotechnology @natbiotech.nature.com · 5mo ago

Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning - @savagecatsonly.bsky.social go.nature.com/4loaOGn

Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning - Nature Biotechnology

TnpB endonucleases are engineered for improved genome editing.

go.nature.com

Savage Lab @savagecatsonly.bsky.social · 8mo ago

New from Ugrappa Nagalakshmi and Jorge Rodriguez 🌱✂️– Gene editing in plants just got a lot easier! Using engineered TnpB, they demonstrate high-efficiency, heritable, transgene-free editing in plants. (1/7)

noam @prywes.bsky.social · 8mo ago

🌱🚨 Funded PhD for UK students 🇬🇧🌿 Take a look at this Plant BioDesign Doctoral Training Program. Come work with me and @michaelwebster.bsky.social to study plant rubiscos. High throughput biochem at Cambridge and Cryo-EM techniques at the John Innes Centre. www.findaphd.com/phds/project...

Engineering plant rubisco enzymes through high-throughput enzyme assays and cryo-EM (Plant BioDesign Cambridge project) at University of York on FindAPhD.com

PhD Project - Engineering plant rubisco enzymes through high-throughput enzyme assays and cryo-EM (Plant BioDesign Cambridge project) at University of York, listed on FindAPhD.com

findaphd.com

Owen Tuck @owentuck.bsky.social · last yr.

Excited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts. tinyurl.com/2uwwy4ty

Recurrent acquisition of nuclease-protease pairs in antiviral immunity

Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...

tinyurl.com

@marialukarska.bsky.social · last yr.

Check out our pre-print on ProteinGuide, a new method for conditioning protein generative models on experimental data! Thanks to the amazing team: @junhaobearxiong.bsky.social, @hnisonoff.bsky.social, Ishan, Luke, @jlistgarten.bsky.social and @davesavage.bsky.social! @savagecatsonly.bsky.social

Junhao (Bear) Xiong@junhaobearxiong.bsky.social · last yr.

Guide your favorite protein generative model with experimental data? Meet ProteinGuide - a method to condition pre-trained models on properties without retraining. We validated it both in silico by guiding ProteinMPNN and ESM3 on 3 tasks and in vitro by engineering base editors.