Markus Elsner
@markuselsner.bsky.social
Deputy Director of the Institute for Intelligent Biotechnologies at HelmholtzMunich, former editor @naturebiotech.bsky.social, all views expressed here are my own
Join us in Munich to learn how to do 3D imagine analysis. Shout out to @klaus-tschira-stiftung.de for supporting this!
Philip Ruthig@philipruthig.bsky.social · yesterdayGot your own (mouse brain-) 3D data from clearing and light sheet imaging, but no idea how to tackle the analysis? We have just the solution for you in Munich: A two-day course on deep learning and VR-assisted segmentation, atlas registration, and so on! Take the course at @erturklab.bsky.social
Fantastic paper demonstrating how LLM editing is gradually distorting our writing and the way we think to write: arxiv.org/abs/2603.18161
How LLMs Distort Our Written Language
Large language models (LLMs) are used by over a billion people globally, most often to assist with writing. In this work, we demonstrate that LLMs not only alter the voice and tone of human writing, b...
arxiv.org
Run Openfold3 on my laptop machine #openfold3 #co-folding #informatics Recently several co-folding AI are available, for example AF3, Chai-1, protenix and openfold. This area is hot and growing day by day. Co-Folding AI has potential for taking SBDD approach without determining the target…
Run Openfold3 on my laptop machine #openfold3 #co-folding #informatics
Recently several co-folding AI are available, for example AF3, Chai-1, protenix and openfold. This area is hot and growing day by day. Co-Folding AI has potential for taking SBDD approach without determining the target protein-ligand structure. As most of readers know that there are still limitation of using co-folding AI for SBDD but really useful I think. I have an interest in openfold because openfold disclose code and has good open scientific community.
iwatobipen.wordpress.com
Japan has now joined Horizon Europe. Japan’s researchers can now partner with teams across the EU. Together, we will advance global research in health, digital technologies, and climate neutrality ↓ link.europa.eu/YP7MtB
Get your calendars, because the new 2027 EMBL Annual Poster has arrived: s.embl.org/2027-poster Whether you'd like to enhance your skills in a practical course or engage with the latest research at one of our conferences, we've got you covered. See you at EMBL in 2027! 🙌 #LifeSciences #EMBL
Seeing is understanding. That's why we're working hard to build the next generation of biomedical imaging at @deeppiction.bsky.social. Because tomorrow's cures begin with seeing what was once invisible. #FluorescenceFriday #PrecisionMedicine
So excited to see this out! CellTune, our software for cell classification in Spatial Proteomics, is published in Nature Methods www.nature.com/articles/s41...
CellTune: an integrative software for accurate cell classification in spatial proteomics - Nature Methods
CellTune enables high precision analysis of spatial proteomics datasets through a human-in-the-loop active learning workflow.
nature.com
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques www.nature.com/articles/s41...
EU relaxes rules for gene-edited crops - Nature Biotechnology
The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques.
nature.com
Halotag--not just for subcellular imaging!! A PET reporter ligand for quantitative imaging of gene expression in the brain | Nature Biomedical Engineering share.google/36uixewsHrYW...
A PET reporter ligand for quantitative imaging of gene expression in the brain - Nature Biomedical Engineering
A small-molecule fluorine-18 HaloTag ligand optimized for entry into the brain and covalent retention at the reporter provides a tool for non-invasive positron emission tomography quantification of gene expression in mouse models.
share.google
amazing, if this works as advertised. few things I hate more than filling these forms in
Lior Pachter@lpachter.bsky.social · 6d agoOne of the major pains of academia is having to click through labyrinths of webpages to submit papers. Now, thanks to Joe Rich (and AI), problem solved! His tool is called PaperPush and is available at github.com/pachterlab/p... It's super easy to use! 1/🧵
One of the major pains of academia is having to click through labyrinths of webpages to submit papers. Now, thanks to Joe Rich (and AI), problem solved! His tool is called PaperPush and is available at github.com/pachterlab/p... It's super easy to use! 1/🧵
GitHub - pachterlab/paperpush
Contribute to pachterlab/paperpush development by creating an account on GitHub.
github.com
Check out what we have been up to recently, as we are now trying to make a real-world difference in Long COVID and other diseases
Ali Maximilian Erturk@erturklab.bsky.social · 6d agoSARS-CoV-2 spike protein accumulates & persists in the body for years👇🏻. We develop advanced imaging/AI to cure Long COVID & beyond👇🏻. Join us 🤗 www.nature.com/articles/s41... www.cell.com/cell-host-mi... www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.1...
Online now: Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells
Environmentally induced cell stiffening shapes metastatic site selection by tuning the immune vulnerability of cancer cells
Adherent cells mimic the mechanical properties of their surroundings, becoming stiffer in more rigid environments and softer in more compliant ones. Elbanna et al. find that this environmentally induced stiffening response shapes metastatic site distribution by preferentially sensitizing cancer cells to cytotoxic lymphocytes in stiff contexts, such as the bone.
dlvr.it
Online Now: Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies
Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies
Meyerhoff et al. identify tumor-infiltrating plasma cells as a source of antibodies with therapeutic potential. Their lead antibody, PC-1, recognizes citrullinated antigens on cancer and tumor-promoting myeloid cells and can be repurposed to guide CAR T cell therapy.
dlvr.it
Brain vascular aging isn’t a single path. Our new work shows that the aging brain diverges into two states: 🧠 Hypovascular (expected) 🧠 Hypervascular (surprising), with BBB leakage, inflammation and cognitive decline. Our study👇🏻: www.biorxiv.org/content/10.6...
Delivery of an in vivo–selected AAV into the glymphatics achieves broad transduction of human glial cells in chimeric mice #NBTNV www.nature.com/articles/s41...
An AAV vector for glial cells - Nature Biotechnology
Delivery of an in vivo–selected AAV into the glymphatics achieves broad transduction of human glial cells in chimeric mice.
nature.com
gosh, England plays like Germany and this is not a compliment
France not looking so much better again Paraguay than we did, at least so far
Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...
Arc mediates intercellular tau transmission via extracellular vesicles
Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…
authors.elsevier.com
In this heat, we watched an afternoon movie with the kids. One of my guilty pleasure movies, just love Indepencdence Day 🫣
AI image generation to illustrate something is almost useful. You can get it about 95% right. But it is 100% impossible to get the last 5% to make it presentable
Why, oh, why did I think that 45 min transfer time between two trains could possibly be enough with Deutsche Bahn. Will miss my last connecting train home. German trains are really a disgrace.
The results of the Advanced Grants 2025 are here! Out of 3,329 applicants, 319 leading researchers have been awarded an ERC Advanced Grant. Congratulations to all! 🎉 Curious to know more ? 👉 buff.ly/uiU9x5K #ERCAdG #FrontierResearch
Structure-guided arRNA design enables precise and expanded endogenous ADAR-mediated RNA editing. #NBThighlight www.cell.com/cell/fulltex...
RNA structure programs endogenous ADAR for precise and efficient editing
LEAPER 3.0, a structurally optimized dual-bulge ADAR-recruiting RNA design platform, achieves precise and efficient endogenous A-to-I RNA editing across diverse ADAR contexts.
cell.com
What a week! My first Points of View was published @natmethods.nature.com Happy to start the series in 🏳️🌈 month with "On Color scales and the birth of Viridis" - looks good, allows naming of regions, AND is perceptually uniform 🎁 rdcu.be/fnPhk www.nature.com/articles/s41... #dataviz
Multispecific T-cell engagers attract cancer drug developers nature.com/articles/d41... Multispecific T-cell engagers that bind three or more targets on cancer and immune cells promise to address the shortcomings of their bispecific predecessors
