Marleen Kok, MD PhD, NKI

@marleenkok.bsky.social

Breast Oncologist and translational researcher @nki, Immunotherapy and immune cell lover, Mother, 🍀🌿

Please donate!🚵🏽‍♂️💵💰 Last year we received a huge grant 🤩from KWF to launch the internat OPTImaL trial to avoid chemo for low stage BC with many immune cells! We strongly feel that we should do something in return for KWF so we will bike 🚵🏽‍♂️the Alpe d’Huez 💪🏼 www.opgevenisgeenoptie.nl/fundraisers/...

Marleen Kok

Ik doe mee aan Alpe d’HuZes omdat ik geloof dat wij samen kunnen werken aan een wereld waarin je niet meer doodgaat aan kanker, wil jij mij steunen?

opgevenisgeenoptie.nl

very important (but negative) trial on cdk46i in mTNBC. huge shout-out to @stolaney1.bsky.social and Shom Goel for conducting this trial👍 @oncoalert.bsky.social #bcsm

Dana-Farber’s Breast Oncology Center@dfcibreastonc.bsky.social · 2y ago

📢 Just published! A phase II study of #abemaciclib for patients with #retinoblastoma-positive, triple-negative #metastatic breast cancer. 🔓https://pubmed.ncbi.nlm.nih.gov/39908010/ @drtimothyerick.bsky.social @nlinmd.bsky.social @stolaney1.bsky.social

Many good things to say on this story @oncoalert.bsky.social @naturemedicine.bsky.social: 1) serious biomarker work from a pharma-sponsored trial👏👏 2) a tumor historically consid cold 🥶can respond to aPD1 🤩3) we need to redefine ER+ disease to enable personalized treatm✍️

Sherene Loi MD@loisher.bsky.social · 2y ago

summary CM-7FL @oncoalert.bsky.social @naturemedicine.bsky.social link: rdcu.be/d8Cw4. Here Nivo ⬆️ pCR rates in high grade HR+ BC. Increasing pCR rates in this subtype is HARD! PD-L1+ & #TIL higher pCR. This study will change how we think about HR+BC- some are immunogenic & need PD-1i with chemo

Big fan of the concept of immunogenic cell death/inducing immunogenicity with 'conventional' therapies - so really looking forward to reading/hearing more about TONIC2 following the nice work from the original TONIC trial by @marleenkok.bsky.social & team @nkinl.bsky.social 👇

Marleen Kok, MD PhD, NKI@marleenkok.bsky.social · 2y ago

Exciting to present 🎤 new data #SABCS24 from TONIC2 study, follow-up from rdcu.be/d22kf. Do immune inductions using low dose dox or cisplatin indeed benefit pts? See us at P1-7-30 and during PS17-9 we show data on TME during acquired resistance to aPD1. With V. Geurts @nkinl.bsky.social @oncoalert