Just analysed 48 single nuclei samples with scprocess and went from fastq files to cell-type annotation in a couple of weeks!! Really recommend this pipeline developed by @willmacnair.bsky.social and team, thank you for making it public!! github.com/marusakod/sc...

GitHub - marusakod/scprocess: Snakemake pipeline for processing single cell data

Snakemake pipeline for processing single cell data - marusakod/scprocess

github.com

Last week I successfully passed my viva 🎓! It was a pleasure to discuss the work with @aidarodrigo.bsky.social, @bayraktarlab.bsky.social and @willmacnair.bsky.social, and to celebrate with the lab @annawilliamslab.bsky.social (thanks for this amazing single-cell hat!)

New preprint! Our workflow for processing single cell and nuclei data, called 🎉 scprocess 🎉 We have been working on it for ~18 months now, over which time we have processed at least 2k samples with it, so it has had a decent amount of testing.

#SingleCell preprints@prepub-singlecell.bsky.social · 5mo ago

scprocess: a pipeline for processing, integrating and visualising atlas-scale single cell data #SingleCell 🧪🧬🖥️ https://www.biorxiv.org/content/10.64898/2026.03.09.710141v1

Latest from the lab, led by @ara-donia.bsky.social and @juliavdkorput.bsky.social Huge team effort, with immense contributions by friends from nearby and around the globe. www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel

Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

science.org

Very happy to share that the work from my PhD is in press at PAIN 😊

The lab went to our institute Halloween party as research models- spot yeast, human, E.coli, naked mole rat, axolotl, fusing organoid, frog, drosophila, excitatory neuron and oligodendrocyte!!!

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function

Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

rdcu.be

This work is finally online as in-press preview! JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

Are you interested in omics approaches to pain and projection neurons? Why not join us? We’ve got a post-doc position available. Happy to discuss further with anyone who is interested. www.jobs.gla.ac.uk/job/research... #neuroskyence #neurosci #PainResearch

EDINBURGH AXOLOTLS! Super-excited to hear my wonderful colleague @aidarodrigo.bsky.social on BBC Radio 4 talking about the axototl colony she has established in our institute @edinuni-irr.bsky.social 😃 Available on BBC sounds: Aida's section starts at 23.37 www.bbc.co.uk/sounds/play/...

BBC Inside Science - How vulnerable is our power supply? - BBC Sounds

Massive power cuts brought parts of Spain, Portugal and France to a standstill this week.

bbc.co.uk

It’s international woman’s day! Well we have a lot of amazing women in our group to celebrate from our fierce leader @annawilliamslab.bsky.social to our PhD students, postdocs, bioinformaticians, and everyone in between💪🏻 Thank you ladies for being amazing scientists, colleagues and friends 💜💙🩵

📢 We are hiring! 📢 We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*. More info and how to apply: tinyurl.com/4m6yzbef Get in touch if interested!

Couple of opportunities up to join the group! One at postdoc level, but open to senior support path. One research assistant role. Please share, or drop a line if you want to learn more! Or just apply! Thanks! elxw.fa.em3.oraclecloud.com/hcmUI/Candid... elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

1/n Some time ago my colleague, excellent cook, and friend Ivan told me: "Cacio e pepe is the recipe that I screw up more often. Let's make a project studying systematically the physics of that sauce". Prepare to get cheesy, I'm glad to share the Cacio e paper preprint: arxiv.org/abs/2501.00536

Preprint alert: Using human microneurography protocols in PatchSeq experiments on pig DRGs we identify the molecular identity of human dermal CMi-fibers (sleeping nociceptors). We provide an integrated pig-human-more transcriptomic atlas and identify OSMR and SST as marker, backed by human expts.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2y ago

Molecular architecture of human dermal sleeping nociceptors https://www.biorxiv.org/content/10.1101/2024.12.20.629638v1

People living with multiple sclerosis #MS could be prescribed personalised treatment in future, helped by research published in Neuron today in which Prof Anna Williams and colleagues studied more than half a million brain cells. @mssocietyuk regeneration-repair.ed.ac.uk/personalised... #CRM

It's Dec 1 and you want to finally start learning R? The R advent calendaR by @kiirsti.bsky.social is an excellent place to start. Do it now! #rstats kiirstio.wixsite.com/kowen/post/t...

The 25 days of chRistmas: an R advent calendaR

Thank you for your interest in this advent calendar and learning R! R is a powerful tool for data analysis and visualization. At first, it can be really overwhelming, but after you pick up the basics,...

kiirstio.wixsite.com

My first first author paper is out! doi.org/10.3390/gene... Main message: 💸 Less expensive sequencing methods can provide just as good quality single-cell data 📊 With David A. D. Munro, Meryam Beniazza, Josef Priller, @annawilliamslab.bsky.social, Andrea Corisnotti