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Matteo Gravino

@matteogravino.bsky.social

Scientist at The Sainsbury Lab, Norwich Research Park. Interested in plant-microbe interactions.

13 Posts53 Follower 50 Folgt

Sophien Kamoun @kamounlab.bsky.social · 3w ago

And when you’re finished reading, read some more…

Sophien Kamoun@kamounlab.bsky.social · 2y ago

Nothing fills me more with hope than a Tunisian biology MSc student reading « The Selfish Gene » 😍 🧬 Read young people. Read, read, read…and never stop.

Sophien Kamoun @kamounlab.bsky.social · 4w ago

Kamoun Lab Alumni & Friends 2026, Assembly House, Norwich kamounlab.dreamhosters.com/Alumni_2026/

Matteo Gravino @matteogravino.bsky.social · 4w ago

🌱 Happy to present our poster, "AI-guided discovery of plant resistance genes", today at #ECPP2026! Our poster is also available on Zenodo: 🔗 doi.org/10.5281/zeno... Many thanks to all the co-authors and collaborators! #PPATH2026 @thesainsburylab.bsky.social @kamounlab.bsky.social

Sophien Kamoun @kamounlab.bsky.social · 5mo ago

Just published a #PreprintReview of “The Magnaporthe oryzae Effector AvrPii Attenuates Rice Immunity by Targeting the Calcium-Associated ANK Protein AVIN8” on @prereview.bsky.social prereview.org/reviews/2034...

PREreview of “The Magnaporthe oryzae Effector AvrPii Attenuates Rice Immunity by Targeting the Calcium-Associated ANK Protein AVIN8”

Authored by Sophien Kamoun and 1 other author

prereview.org

Matteo Gravino @matteogravino.bsky.social · 6mo ago

Walking through history.📍Appia Antica, Santa Maria delle Mole access. The real Roman countryside experience. ✨ #AppiaAntica #Rome #TravelItaly #Ciampino #HiddenGems

Ham, Buffalo Mozzarella Cheese, white pizza bread. From: Caseificio Cuor Di Bufala srls, Santa Maria delle Mole

The Sainsbury Laboratory @thesainsburylab.bsky.social · 8mo ago

We are incredibly excited by TSL spinout @ResurrectBio's successful initial closing of its Series A funding round at ⭐️ $8.1M ⭐️ Resurrect Bio is revolutionizing agriculture by equipping crops with genetic defenses against disease 🌱🛡️ www.tsl.ac.uk/news/tsl-spi...

Resurrect Bio celebrates $8.1M initial close of Series A

tsl.ac.uk

Sophien Kamoun @kamounlab.bsky.social · 8mo ago

It’s that time of year! #SchoBozKa in Downing College, Cambridge 🇬🇧 Running strong since 2017–Annual lab meeting of the teams of Sebastian Schornack, Lida Derevnina, Phil Carella, Jiorgos Kourelis and Sophien Kamoun. This year’s guest is Steven Spoel, University of Edinburgh

Sophien Kamoun @kamounlab.bsky.social · 8mo ago

Join us on March 10, 2026 at Kyoto University 🇯🇵 for a day celebrating my long-time friend and collaborator Prof. Ryohei Terauchi. "Kyoto Mini-Symposium on Plant–Microbe Interactions"

Sophien Kamoun @kamounlab.bsky.social · 8mo ago

We’re hiring! Postdoctoral Researcher / Research Assistant @KamounLab “Biology and Applications of Plant Immune Receptors” www.tsl.ac.uk/working-at-t...

Matteo Gravino @matteogravino.bsky.social · 10mo ago

Thrilled to join the @kamounlab.bsky.social! Looking forward to contributing and collaborating on exciting projects ahead. Thanks for the warm welcome Sophien!

Sophien Kamoun@kamounlab.bsky.social · 10mo ago

A belated welcome to Matteo Gravino @gravino_matteo to our team. Matteo joins us as a postdoctoral researcher, having previously worked at the John Innes Centre in the group of Saskia Hogenhout. We are excited to having you on board Matteo! kamounlab.tumblr.com/post/8020884...

Clémence Marchal @clemmar.bsky.social · 10mo ago

Excited to share our latest work on plant immune receptor biochemistry! @kamounlab.bsky.social @hsuanpai.bsky.social @mpcontreras.bsky.social Jose Salguero Linares @danielluedke.bsky.social @adnroide.bsky.social @jiorgoskourelis.bsky.social www.biorxiv.org/content/10.6...

CC-NLRs exhibit diverse conformations in the resting state.
Figure depicts different NLR resting and activated states. While ZAR1 exists as a monomer bound to its guardees in its resting state, several forms have been observed for the NRC2 helper, including dimers, tetramers, and filaments. While filament-like structures were observed via confocal microscopy for NRC2 upon overexpression in planta, these structures were not detected for its paralog NRC4, suggesting a potentially different resting state configuration for NRC4. Our work suggests that the Pik CC-NLR pair forms a hetero-complex bound to the plasma membrane in its resting state. How effector binding to the integrated domain (ID) of the Pik-1 sensor leads to the activation of the complex remains to be determined.

Sam Mugford @samtmugford.bsky.social · last yr.

Now published in @newphyt.bsky.social , congrats @matteogravino.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social nph.onlinelibrary.wiley.com/doi/10.1111/...

nph.onlinelibrary.wiley.com

Marc Somssich@somssich.bsky.social · 2y ago

📜 Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses 🧑‍🔬 @matteogravino.bsky.social, @saskiahogenhout.bsky.social, et al. 📔 @biorxiv-plants.bsky.social 🔗 www.biorxiv.org/content/10.1... #️⃣ #PlantScience #PlantImmunity

Matteo Gravino @matteogravino.bsky.social · last yr.

🎉Thrilled to share our latest work, now published in @newphyt.bsky.social! 🧑‍🔬 @matteogravino.bsky.social, @samtmugford.bsky.social, @saskiahogenhout.bsky.social et al., @johninnescentre.bsky.social #️⃣ #PlantScience #PlantImmunity 📄 Read the full paper👇 nph.onlinelibrary.wiley.com/share/8QSRJ9...

Model: Activation and suppression of defences in plant–aphid interactions. Upper left panel: aphid stylet penetration of the cell wall releases oligogalacturonides (OGs), which induce PAMP/DAMP-triggered immunity (PTI/DTI) in a process dependent on BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 (BAK1), ENHANCED DISEASE SUSCEPTIBILITY 1 (EDS1), and CPK5/6/11 (data herein). The stabilisation of pattern recognition receptors (PRRs) and coreceptors at the plasma membrane may rely on the deubiquitination (DUB) activity of ASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (AMSHs; Gravino et al., 2024). Upper right panel: the Mp10 effector, introduced by aphids into the cell cytoplasm (Mugford et al., 2016), suppresses OG-induced reactive oxygen species (ROS) (data herein) and flg22-induced PTI (Bos et al., 2010). Mp10 targeting of plant AMSHs is implicated in these processes (Gravino et al., 2024). EDS1 is essential for Mp10-mediated ROS suppression and PRR destabilisation (data herein), acting through an unidentified mechanism (denoted by the double-sided arrow with an asterisk). Lower left panel: effector-triggered immunity (ETI) is activated through EDS1, either directly or indirectly, upon recognition of Mp10 and/or its activities by a TNL (Gravino et al., 2024; Rao et al., 2024). Salicylic acid glucosyltransferase 1 (SGT1) is also required for TNL/ETI activation (Bos et al., 2010). Lower right panel: aphids secrete additional effectors, such as cathepsin B proteins (e.g. CathB6), which target EDS1 to suppress ETI (Liu et al., 2025). Solid arrows, increased activation; solid blunt-ended arrows, increased suppression; Dashed arrows, reduced activation; Dashed -blunt-ended arrows, reduced suppression.

Sam Mugford @samtmugford.bsky.social · last yr.

Aphid Saliva fans, happy news, this amazing story is now out in Science Advances www.science.org/doi/10.1126/... congrats @qunliu07.bsky.social @saskiahogenhout.bsky.social et al @johninnescentre.bsky.social 24h after a triumphant presentation at #ismpmi2025

Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies

Aphids hijack plant immunity via p-bodies, but plants fight back with a heat shock protein in an unexpected twist on defense.

science.org

Qun Liu@qunliu07.bsky.social · 2y ago

We're happy to present a pre-print from the Hogenhout lab (@saskiahogenhout.bsky.social), describing how a family of proteases in aphid oral secretions suppress plant immunity.

Baptiste Castel @baptistebio.bsky.social · 2y ago

🔗 Preprint alert: www.biorxiv.org/content/10.1... 🧵 New insights into plant immunity: using ferns to understand evolution! 🌱✨🌿 Excited to share my first (but not last) published research at @lrsv-toulouse.bsky.social. A THREAD … [1/9]

Exploring fern pathosystems and immune receptors to bridge gaps in plant immunity

Land plants include angiosperms, bryophytes, lycophytes and ferns, each of which may deploy distinct strategies to resist pathogens. Here, we investigate fern-pathogen interactions by characterizing n...

biorxiv.org

Marc Somssich @somssich.bsky.social · 2y ago

biorxiv.org

Sam Mugford @samtmugford.bsky.social · 2y ago

We are excited to share our latest preprint from the Hogenhout lab (@matteogravino.bsky.social @saskiahogenhout.bsky.social , @johninnescentre.bsky.social ) on plant-aphid interactions, showing that the aphid effector Mp10 balances suppression of DAMP responses and activation of ETI via EDS1.

bioRxiv Plant Bio@biorxiv-plants.bsky.social · 2y ago

Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses https://www.biorxiv.org/content/10.1101/2025.02.26.640334v1

Sam Mugford @samtmugford.bsky.social · 2y ago

We’re delighted to share our latest preprint from the Hogenhout lab (@saskiahogenhout.bsky.social) on the molecular mechanisms on plant-aphid interactions. Here we show how the aphid Mp10 effector protein acts as a local anaesthetic to suppress the plant perception of aphid attack

bioRxiv Plant Bio@biorxiv-plants.bsky.social · 2y ago

The conserved aphid saliva chemosensory protein effector Mp10 targets plant AMSH deubiquitinases at cellular membranes to suppress pattern-triggered immunity https://www.biorxiv.org/content/10.1101/2024.11.15.622802v1