1/ New preprint! with @solersanchisx.bsky.social @cwjpugh.bsky.social @federicobilleci.bsky.social @jonnyfrazer.bsky.social and Mafalda Dias, we introduce a scalable framework to improve stability prediction and separate folding from functional constraints. www.biorxiv.org/content/10.6...

Blending physics-based and inverse folding models to disentangle variant effects on stability and function

Protein sequences are constrained not only by the need to fold into stable structures, but also by specific functional requirements imposed by natural selection. Yet predictions of how amino-acid chan...

biorxiv.org

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Wow! A fourth class of transmissible cancers. CONTAGIOUS FISH MELANOMA, discovered in Lake Memphremagog (Vermont / Quebec) 🎣 🧬 😷 www.nature.com/articles/s41... @uvmvermont.bsky.social

Brown bullhead catfish melanoma represents a novel transmissible cancer - Nature

Whole-genome sequencing analysis of tumour and matched non-tumour host tissues of the brown bullhead catfish reveals a type of naturally occurring transmissible cancer.

nature.com

Oh wow, the Venus flytrap closure mechanism 🤩🌱! Looks like an awesome starting point for nature-inspired materials design ... www.science.org/doi/10.1126/...

Fast cell wall softening causes Venus flytrap closure

Plants can move rapidly without muscles, as seen in the Venus flytrap’s snapping lobes—a long-standing puzzle in plant biomechanics. Trap closure involves an elastic instability, but the active mechan...

science.org

Science Magazine@science.org · 2mo ago

New research in Science reveals that the Venus flytrap's snap is triggered by a rapid softening of the epidermal cell walls, uncovering the physical mechanism behind this remarkable movement. Learn more in this week's issue: https://scim.ag/4fXQ9sn

🌱🧬W3 Professorship in Plant Biotechnology at the University of Freiburg The position holder will lead a research program that combines excellent basic research with clear perspectives for biotechnological & societally relevant applications #plantscience #plantscijobs www.nature.com/naturecareer...

W3 Professorship for Plant Biotechnology - Freiburg im Breisgau, Baden-Württemberg (DE) job with University of Freiburg (Uni Freiburg) | 12859402

The future position holder will lead an internationally recognized research program that combines excellent basic research with clear perspectives for

nature.com

And risen star

What if living cells compute in ways that silicon never can? Rather than mimicking computers, the future of biocomputation may lie in harnessing the unique information-processing strategies of evolution. Check this paper by @angelgm.eurosky.social and co. www.sciencedirect.com/science/arti....

Molecular biologist & geneticist Susan Lindquist (b. #OTD in 1949) was a pioneer in studying protein folding. Her research demonstrated protein folding errors contribute heavily to neurodegenerative conditions like Alzheimer's & Parkinson's diseases. National Medal of Science in 2010. #WomenInSTEM

Congratulations to CRG's @benlehner.bsky.social on receiving the 2026 Premio Rei Jaume I for Biomedical Research. The award recognises his pioneering discoveries on genetic variation, evolution and disease, helping transform our understanding of biology and human health. #genomics #genetics #CRG

📢📢 Job opening between the Bioinformatics Unit and my group (REPBIO) at @crg.eu Interested in contributing to our efforts to leverage long-read sequencing technologies for human genome research? Join us in Barcelona: recruitment.crg.eu/content/jobs... Please repost😊

1\ Excited to finally share some of my PhD work: OpenSplice! We measured how >590,000 mutations affect exon inclusion across 600 human exons, creating a resource to study splicing regulation, benchmark variant effect predictors, and support variant interpretation.

bioRxiv Genomics@biorxiv-genomic.bsky.social · 2mo ago

OpenSplice: the impact of half a million mutations on the alternative splicing of 600 human exons https://www.biorxiv.org/content/10.64898/2026.05.22.727141v1

Accurate protein stability prediction for small domains using mega-scale experiments https://www.biorxiv.org/content/10.64898/2026.05.19.726285v1

Now published in NSMB! Paper: doi.org/10.1038/s415... Full PDF: rdcu.be/fhBtI Overview of additions since the preprint👇 (1/5)

Evaluating generalization in protein–ligand cofolding methods - Nature Structural & Molecular Biology

This work introduces the Runs N’ Poses dataset for benchmarking deep learning methods on the protein–ligand complex prediction task. It shows that current methods rely on memorization, challenging the...

doi.org

Peter Škrinjar@peterskrinjar.bsky.social · last yr.

Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹! www.biorxiv.org/content/10.1... 🧵👇 (1/n)

🌱 "Don't judge each day by the harvest you reap but by the seeds that you plant" —Robert Louis Stevenson

1/ Excited to share our new paper in Science @science.org: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” A great collab w/ Sergey's group @sokrypton.org at MIT @columbiasysbio.bsky.social science.org/doi/10.1126/... 🦠🧬🛠️🖥️💥

Toward life with a 19–amino acid alphabet through generative artificial intelligence design

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

science.org

We are looking for a new Director @cragenomica.bsky.social to help us keep growing and making even cooler science, come join us!, Application details www.cragenomica.es/sites/defaul... please, help us spread the word!

Another weekly reminder of the promise of sequencing airborne eDNA. So much to do. So much to learn. 🧬 🌍 🧑‍💻 www.nature.com/articles/d41...

The air is full of DNA — here’s what scientists are using it for

Airborne genetic material can be used to paint a picture of ecosystem health, watch for invasive species and even identify humans.

nature.com

The latest AI/ML tools for co-folding proteins around small molecule ligands can produce impressive results. Until you start looking at them closely.

AI-Predicting Compound Affinity. We Aren't There Yet.

science.org

On the uses and misuses of airborne DNA detection 🌬️🌱🧬 www.elperiodico.com/es/ciencia/2... 🇪🇸 with David Duffy @ufresearch.bsky.social in @elperiodico.com

Ya es posible extraer ADN humano del aire: riesgo de una vigilancia masiva

Extraer ADN del aire permite detectar patógenos y monitorizar la biodiversidad. Sin embargo,esto puede convertirse en una herramienta de control y los expertos llaman a la regulación del sector.

elperiodico.com

Our warmest congratulations to #ICREAResearcher José Luis Riechmann and team at @cragenomica.bsky.social! They discovered tiny peptides that could be key for flower development, conserved across plant species. 🌿🧪

CRAG (@cragenomica.bsky.social)

Twenty-five years after the sequencing of the human genome, scientists are still uncovering hidden layers of the “book of life”. A team led by CRAG researcher José Luis Riechmann published the first characterization of peptides derived from sORFs during flower development in Arabidopsis thaliana 🌸🔬

bsky.app

Very few things in academia are as rewarding as witnessing the progress and growth of your students, their research and discoveries over the years. Such a nice weekend read by @robjohnnoble.bsky.social 🫶 (also: great title!)

Rob Noble@robjohnnoble.bsky.social · 5mo ago

Academics often lament that hardly any master’s projects get published. The student moves on. Other research takes priority. No one has time to do the final analyses. Here I tell how one master’s project was, through persistent teamwork, finally carried over the finish line: go.nature.com/4aKs7N3

Wonderful to have David Duffy with us last week! Lots of new biodiversity genomics and eDNA approaches in the making ... 🧬🐢🌦️ @crg.eu @prbb.org @ufresearch.bsky.social

Parc de Recerca Biomèdica de Barcelona@prbb.org · 6mo ago

🔴 TODAY ‼️📣 PRBB-CRG conference 📋 Airborne Biodiversity Genomics – rapid ecosystem health, wildlife and pathogen monitoring 🗣️ David Duffy - Whitney Lab, University of Florida 📆 Feb 20 - ⏰ 12:00 hosted by: Max Stammnitz - @crg.eu      📍 #PRBB Marie Curie room

🌱 Join us tomorrow for the seminar "Deep mutational scanning of plant hormone receptors" by Maximilian R. Stammnitz (@maxstammnitz.bsky.social) from the Center for Genomic Regulation (@crg.eu) 👀 Don't miss it! 👉 https://f.mtr.cool/pgnowtoakf

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

Recent discoveries on the acquisition of the highest levels of human performance

Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

science.org

O maior fotógrafo do Brasil e um dos maiores do mundo descansa hoje. Vá em paz, Sebastião Salgado.

1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.

 www.biorxiv.org/content/10.1...

 With @benlehner.bsky.social [1/7]

The genetic architecture of an allosteric hormone receptor

Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...

biorxiv.org