Thrilled to share that our scE2G paper is now published in Nature Genetics! www.nature.com/articles/s41... scE2G predicts enhancer-gene regulatory interactions from single-cell data with state-of-the-art performance. Amazing work led by @mayayayas.bsky.social and @613weilin.bsky.social!

Mapping enhancer–gene regulatory interactions from single-cell data - Nature Genetics

scE2G is a family of models that predict enhancer–gene regulatory interactions from single-cell datasets and enable mapping of these interactions across diverse cell types and tissues.

nature.com

Jesse Engreitz@jengreitz.bsky.social · 2d ago

Update: scE2G is now online at Nature Genetics! Since the preprint, we added a new benchmark on a fully held-out CRISPR dataset. scE2G continues to show state-of-the-art performance, reinforcing that it generalizes well nature.com/articles/s41588-026-02695-8 1/

Sailing in @biorxivpreprint.bsky.social ready for summer, our study on the iconic Portuguese man o' war 🪼 is out: www.biorxiv.org/content/10.6.... We use (epi)genomics to understand a critter that fascinates me since childhood. Massive team effort with @obog.bsky.social, Cummins and Neely groups. 🧵

Happy to share the final version of our study on the evolution of chromatin states across eukaryotes, out today in @natgenet.nature.com Led by @crisnava.bsky.social and @seanamontgomery.bsky.social www.nature.com/articles/s41... Some highlights below

Diversity and evolution of chromatin regulatory states across eukaryotes - Nature Genetics

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

nature.com

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

We're hiring 4 postdocs at @unibo.it to study nervous system evolution. Seeking expertise in single-cell genomics, molecular or developmental biology in ctenophores, cnidarians, echinoderms, flies or human stem cells. 2+2 yrs contract. Deadline: 26 Aug. Please share! bandi.unibo.it/s/apos7/proc...

Procedura di valutazione comparativa per titoli e colloquio per il conferimento di n. 4 contratti di ricerca presso il Dipartimento di Scienze Biologiche, Geologiche e Ambientali - SSD BIOS-04/A - GSD...

bandi.unibo.it

Open position in our lab for a research engineer. The applicant must hold a PhD in life sciences and have demonstrable experience in molecular biology and biochemistry. For more info: emploi.cnrs.fr/Offres/CDD/U...

Institut Jacques Monod@ijmonod.bsky.social · 6d ago

#JobOffer 💼 Research Engineer (M/F) 📆 October 15th 📍Institut Jacques Monod, @sandraduharcourt.bsky.social 🔗 emploi.cnrs.fr/Offres/CDD/U...

So happy to share our new paper out now in @natmicrobiol.nature.com! We establish Pirsonia-Coscinodiscus as a model pathosystem and uncover how this tiny parasite infects and kills bloom-forming marine diatoms 🌊🦠 rdcu.be/fuQyF

🚨 Job Alert - Please share 🙏 Interested in 3D gene regulation in development & evolution? 🤓🧬 💥 Our lab at @cabd-upo-csic.bsky.social is expanding! ✅ 4 years fully funded PhD position 💻🧪 Experimental or computational backgrounds welcome 👇 Details below #PhDPosition #PhDOpportunity #AcademicJobs

The third chapter in our coral single-cell trilogy is here. After mapping cell type diversity in Stylophora (Levy 2021) and exploring facultative symbiosis in Oculina (Levy 2025), we now uncover cell type-specific responses to heat stress. Find out more in @xgrau.bsky.social's thread below.

Cell-resolved transcriptional responses during heat-induced coral bleaching and recovery

Coral reefs depend on an intracellular symbiosis between cnidarian hosts and photosynthetic dinoflagellates that is disrupted by ocean warming, causing coral bleaching. Yet how these responses are dis...

biorxiv.org

Xavier Grau-Bové 🌾@xgrau.bsky.social · 2w ago

I'm happy to share our latest on #coral single-cell biology: a transcriptomic timecourse of heat stress in Stylophora pistillata, from bleaching to recovery 🪸🌊 This project was spearheaded by Shani Levy and carried through in @arnausebe.bsky.social's lab at @crg.eu. www.biorxiv.org/content/10.6...

🎨 job alert 🐠 Come join us! We have two positions open! These are part of our @erc.europa.eu funded project on the mechanisms underpinning convergence of colour patterns in cichlid fishes! Closing date: 16th August. Postdoc: www.cam.ac.uk/jobs/researc... Technician: www.cam.ac.uk/jobs/researc...

Callipterus Cichlid Collecting Shell

ALT: Callipterus Cichlid Collecting Shell

static.klipy.com

Our News & Views article “Body-plan organizer in comb jellies hints at animal ancestry” now published in @nature.com 🎉 We discuss fascinating work revealing organizer activity in comb jellies & the evolution of animal development. rdcu.be/fsLWq @ruthstyfhals.bsky.social @msarscentre.bsky.social

I had an (honestly) really fun time writing up an "In Preprints" piece on the two fantastic studies from @grandlab.bsky.social and @schubelerlab.bsky.social. Check it out here. I have also put the original threads from the authors below. journals.biologists.com/dev/article/...

In preprints – housekeeping the housekeeping genes

The term ‘housekeeping gene’ evokes a sense of banality. These are the boring genes that hum in the background, impervious to cell state or stress. For a developmental biologist captivated by the impa...

journals.biologists.com

Discovery of an adhesion GPCR regulating mating in choanoflagellates, by Alain Garcia de las Bayonas & Nicole King. Absolutely stunning work - choano cell biology is going next level www.biorxiv.org/content/10.6...

Our group is moving from @mpi-bio-fml.bsky.social to the maritime city of Kiel! ⛵️🩵 I will lead the Department of Marine Plant Development and Physiology @uni-kiel.de 🌱🪸🌊 Look out for opportunities to join us in this exciting & growing hub for Plant, Marine & Evolutionary Biology in North Germany 🇩🇪

Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...

Emergence of histone-based chromatin complexity in Asgard archaea

The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...

biorxiv.org

Super excited that the first preprint from the lab is out! Led by an amazing student, Gaurav @gvaidya.bsky.social, jointly supervised with @mwdorr.bsky.social.

Gaurav Vaidya@gvaidya.bsky.social · last mo.

The first preprint from my PhD is out! :thread: How does an animal choose between two completely different reproductive fates? Here’s how one planarian does it :point_down: www.biorxiv.org/content/10.6...

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

I'm old enough to remember QED's authors said it's just providing an author with internal feedback, and emphatically isn't trying to mimic human review. Now it's compared to human review or journal selectivity and used to rank (other people's) work. The authors seem to ignore the black box aspect1/3

QED Science@qedscience.bsky.social · last mo.

🎉 Meet The 1%. Out of 57,455 bioRxiv life science preprints, QED Science selected 574 exceptional manuscripts through blind evaluation. The 1%: the-one-percent.qedscience.com Good science deserves to be seen. @biorxivpreprint.bsky.social @openrxiv.bsky.social @richardsever.bsky.social

First pre-print from the lab, a collaborative effort led by Jess Bourn @bournsupremacy.bsky.social, a fantastic PhD in my group. We resolve a key problem in development + evolution: how do we quantify heterochrony and link temporal variation to phenotype? www.biorxiv.org/content/10.6...

Quantitative mapping of heterochrony to species-specific phenotypes

The genetic program of animal development is conserved, but its rate of execution varies across species. Heterochrony, shifts in the relative timing of developmental events, generates phenotypic varia...

biorxiv.org

If the genome is not a blueprint, what is it? My attempt to unravel this particularly knotty question, in @quantamagazine.bsky.social www.quantamagazine.org/why-the-huma...

Why the Human Genome’s Tangled Physicality May Confound AI | Quanta Magazine

Our genetic heritage is not a blueprint or an algorithm, as many biologists have imagined, but something else entirely.

quantamagazine.org

Do you work with scRNAseq data in non-model organisms that have less-than-stellar gene annotations? ✨ 🧬 You might be interested in GeneExt, a nifty little tool by @zolotarg.bsky.social in @arnausebe.bsky.social's lab, published in #Bioinformatics earlier this year. #singlecell #transcriptomics

GeneExt: a gene model extension tool for enhanced single-cell RNA-seq analysis

AbstractMotivation. Incomplete gene models negatively impact single-cell gene expression quantification. This is particularly true in non-model species whe

academic.oup.com

Congratulations to @kremnyovs.bsky.social, @tclebedeva.bsky.social and @hejnol.bsky.social - this is a fantastic paper. www.nature.com/articles/s41... Very happy to have been part of this collaboration.

A blastoporal organizer in a ctenophore - Nature

Experiments using the comb jelly Mnemiopsis leidyi and the sea anemone Nematostella vectensis reveal that the emergence of a core signalling pathway may have been a key innovation enabling the transit...

nature.com

Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...

sPYce is now published in Nature Ecology and Evolution! sPYce is a method to integrate single-cell regulatory data across species, without requiring whole-genome alignments between species. More below ⬇️ www.nature.com/articles/s41...

Long-term aggregation induced by bacteria in the filasteran Ministeria, with increased mating frequency inside aggregates. Truly remarkable observations by JP Gerdt, @multicellgenome.bsky.social and team! www.nature.com/articles/s41...

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Minimal essential requirements for neural tube self-organisation

The reliable generation of diverse cell types in precise proportions is essential for the formation of functional tissues during embryonic development. Three-dimensional organoid models derived from p...

biorxiv.org

"Humbled to receive this recognition. This belongs as much to my team, my family, & to my home, Palestine: the people, the place, the joyful stubbornness to enjoy life." Cheers buddy @gautamdey.bsky.social Thx to my mentors @sophiemartinlab.bsky.social, @paveltomancak.bsky.social, & Pierre Gönczy.

EMBO@embo.org · 2mo ago

Congratulations to Gautam Dey (EMBL) and Omaya Dudin (University of Geneva) for being awarded the EMBO Gold Medal 2026 in recognition of their outstanding contributions to the #LifeSciences in Europe! 🧪 https://www.embo.org/press-releases/embo-gold-medal-2026-awarded-to-gautam-dey-and-omaya-dudin/

A big preprint from my group! Muller Elements are considered to be conserved in flies. We tested it by reconstructing the ancestral dipteran karyotype using 340 chromosomal genomes and suprise suprise, they're not... Led by @juliagries.bsky.social and Sam Ebdon. www.biorxiv.org/content/10.6... 🧵👇

We are looking for a new colleague to join us in Galway. The position is in Biochemistry and if research focus lines up we hope the successful person will join us in the Centre for Chromosome biology (chromosome.ie). Reach out if you are interested in applying! tinyurl.com/2jy4rj3r

A fossil nervous system meets modern neurobiology. We found that a living comb jelly preserves neural architecture remarkably similar to those inferred from Cambrian fossils over 500 million years old 🤩. www.biorxiv.org/content/10.6...