Our new study is out in Nature Communications. Using TNBC organoid mouse models, we show that necroptosis in both tumour and stromal compartments cooperatively drives effective responses to immunogenic cell death–based immunotherapy. 🔗 www.nature.com/articles/s41...

Fantastic talk by @goico13.bsky.social at today’s Science Bites on targeting the dark epigenome to activate anti-tumour responses. @icr.ac.uk @breastcancernow.bsky.social

We're looking for a Scientific Operations Project Manager to join us at ICR, London. Role is aimed at establishing new funding streams, collaborations with biotech. and pharma and managing collaborations with other academic groups. jobs.icr.ac.uk/vacancies/11...

Scientific Operations Project Manager in Chelsea | The Institute of Cancer Research

View details and apply for this Scientific Operations Project Manager vacancy in Chelsea . Salary : Commencement on the salary range is subject to comparable skills and experience. Future p...

jobs.icr.ac.uk

www.bbc.co.uk/news/article.... Excellent news for breast cancer patients, based on great work from ICR scientists including our own Nick Turner.

New pill can slow progression of incurable breast cancer

Around 3,000 women a year with advanced cancer could benefit from capivasertib which can slow the disease.

bbc.co.uk

NEWS: NICE has recommended capivasertib for advanced #BreastCancer. The decision makes the targeted drug available, in combination with fulvestrant, for some NHS patients with the most common type of breast cancer. Read more about the history of the drug⬇️ www.icr.ac.uk/about-us/icr...

We have a great lineup and many short talk opportunities! Come join us in Suzhou!

It was pleasure to welcome @francischan.bsky.social at the @icr.ac.uk today. Great talk about the latest work on cell death in maintaining normal tissue homeostasis and disease. Followed by brainstorming white board discussion.

We’re hiring! Fancy working on cutting edge mouse models and single cell and spatial phenotyping to understand the evolution of therapy resistance in breast cancer? Join us! jobs.icr.ac.uk/vacancies/11...

Postdoctoral Training Fellow - Functional Genomics in Chelsea | The Institute of Cancer Research

View details and apply for this Postdoctoral Training Fellow - Functional Genomics vacancy in Chelsea . Salary: £45,600 - £49,350 p.a. inclusive dependent o n relevant Postdoctoral...

jobs.icr.ac.uk

@asharpmedonc.bsky.social gave an excellent discussion on #prostate cancer, highlighting unanswered biological questions and treatment challenges, during our Whiteboard Meeting.

Thanks to those who politely pointed out we initially made a list of Metastasis Researchers... we've now made a starter pack! ☺️ go.bsky.app/KasKkhK Drop us a message or reply here to be added. More to follow over the coming days. 🦋

For cancer biologists looking for a change of scene, job, or even country… we are advertising for someone to head up our Centre for Target Validation and bring through new cancer drug targets: jobs.icr.ac.uk/vacancies/47... Based on our campus in Sutton, south London

Head of Biology and Director, Centre for Target Validation (Group Leader) in Sutton | The Institute of Cancer Research

View details and apply for this Head of Biology and Director, Centre for Target Validation (Group Leader) vacancy in Sutton. Competitive Starting Salary Tenure : Appointments will be mad...

jobs.icr.ac.uk

Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more. To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲 go.bsky.app/TdKYuS7

On the migration of the scientific community to Bluesky: www.nature.com/articles/d41... 🧪

Bluesky’s science takeover: 70% of Nature poll respondents use platform

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

nature.com

Very scary. www.science.org/content/arti...

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring

Researchers facing

science.org

Thrilled to start 2025 with our latest findings! Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive. www.cell.com/cell-reports...

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection

Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ ...

cell.com

🆕 We're getting in on the act with an ICR research #StarterPack. Check it out! ⤵️ Let us know if you're a #cancer researcher at the ICR and The Royal Marsden but not in the pack. 💬 #CancerResearch #CanSky #OncSky go.bsky.app/EGXU5V1

Congratulations Crescens and well done for passing your PhD viva with flying colours! Great work between @icrlondon.bsky.social and Royal Marsden Hospital. 👏

Exonization of transposons leads to the formation of new protein-coding sequences, potentially impacting immune regulatory pathways. www.cell.com/molecular-ce...

Transposon exonization generates new protein-coding sequences

In a recent issue of Cell, Arribas et al. and Pasquesi et al. explore the phenomenon of transposable element (TE) exonization and its impact on proteomic and immune diversity, highlighting its potential role as a driver of evolutionary innovation.

cell.com

Thrilled to share our @sciimmunology.bsky.social paper! We report that rodent PD-1 is weaker than human PD-1 (reduced ligand binding & signaling) & lacks a conserved vertebrate motif. Humanizing mouse PD-1 disrupts T cell anti-tumor responses, raising many questions. science.org/doi/10.1126/...

☕This year, in our #CellDeath focus: Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer. 👉https://rdcu.be/d493Q www.nature.com/articles/s41...

Exploiting ferroptosis vulnerabilities in cancer - Nature Cell Biology

Ferroptosis is a form of cell death that is characterized by morphological abnormalities of mitochondria and the overwhelming peroxidation of phospholipids. Certain tumours are susceptible to ferropto...

nature.com

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

cell.com

Hi Bluesky community! 👋 Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look! ➡️ s.embl.org/poster-bl #EMBLEvents #molecularbiology #lifesciencetraining

Happy holidays from the Meier lab! Thank you everyone from the team! We are so proud and lucky to have such talented and wonderful group of scientists.

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

nature.com

We are offering a very exciting PhD project 🤩-Project 2- in this great training program! @icrlondon.bsky.social @imperialcollegeldn.bsky.social @crukconvergence.bsky.social Please share 😊 ! Design of advanced therapeutics against metastasis👇 www.convergencesciencecentre.ac.uk/training/con...

This will be the largest broad-spectrum cancer conference in the UK next year. bacr.org.uk/event/bacr-6...

Blocking IRE1α enables RNA accumulation, triggering ZBP1-driven cell death and making cold TNBC tumors ICI-sensitive! www.cell.com/cell/fulltex...

IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer

Mechanisms dictating the form of chemotherapy-induced cancer cell death are elusive. This study reports that immunologically cold triple-negative breast cancer (TNBC) hijacks an ancient ER stress resp...

cell.com

Our Centre for Target Validation is there to help translate the amazing depth of knowledge of cancer biology into new drug discovery projects, and we are looking for the right person to lead this. jobs.icr.ac.uk/vacancies/47...

Head of Biology and Director, Centre for Target Validation (Group Leader) in Sutton | The Institute of Cancer Research

View details and apply for this Head of Biology and Director, Centre for Target Validation (Group Leader) vacancy in Sutton. Competitive Starting Salary Tenure : Appointments will be mad...

jobs.icr.ac.uk

Are you ready for this? We are on Bluesky too!!! Follow the account of NATURE CELL BIOLOGY below! bsky.app/profile/natu...

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists

docs.google.com