Tommy Vierbuchen
@tvierbuchen.bsky.social
VP Research at Cellular Intelligence. Formerly Assistant Professor Dev Bio Program + Center for Stem Cell Biology at Sloan Kettering. cellularintelligence.com
New preprints! 1/3 Spider venom glands are modified salivary glands which have recruited appendage and myogenic programs from other the developmental programs of other organs. Led by Giulia Zancolli, with @yehumoran.bsky.social doi.org/10.64898/202...
I am excited to announce that I have joined Cellular Intelligence as VP Research. Looking forward to working with their world-class team to develop new approaches for understanding and manipulating stem cell fate decisions. www.cellularintelligence.com
Cellular Intelligence
We are building a future where biology is no longer destiny, but design.
cellularintelligence.com
Think I might have chosen the experts at one of the worlds most admired zoos *that has been doing this for 50 years*.
Carl Zimmer@carlzimmer.com · 2mo agoThe US government is entering a partnership to store frozen cells and other biological samples from endangered and threatened species with Colossal, a private company best known for claiming to "de-extinct" dire wolves. Story by me & @catrineinhorn.bsky.social Gift link: nyti.ms/43Rzhfw
Nice write up by Ian Demsky about our work as part of the NIH MORPHIC Consortium together with @studerl.bsky.social, @danweihuangfu.bsky.social, and Ting Zhou labs. www.mskcc.org/news/morphic...
MorPhiC: Inside the Ambitious Project To Understand the Function of Every Human Gene | Memorial Sloan Kettering Cancer Center
MSK scientists are part of an international consortium working to determine the biological functions of the roughly 20,000 protein-coding genes in the human genome.
mskcc.org
IMPORTANT study from @hocinerekaik.bsky.social @denisduboule.bsky.social and a significant validation of SCBEMs, #gastruloids in particular, as a discovery tool www.biorxiv.org/content/10.6... 🧵
This perspective piece reviews new omics, developmental genetic, and cell lineage studies to critically review current models of developing forebrain organization. Spoiler: there are _serious_ problems with the prosomere model.
Elizabeth Manning@emmanning.bsky.social · 3mo agoWell done to @elsieplace.bsky.social, Marysia Placzek and @sethblackshaw.bsky.social for this beautifully clear overview of a very complex history of brain developmental models www.sciencedirect.com/science/arti...
This looks interesting... www.cell.com/neuron/abstr...
A lineage-based model of scalable positional information in vertebrate brain development
How is brain development coordinated over long distances as it grows from a single zygote to billions of cells? Kerstjens et al. propose that positional information is inherited through the cell linea...
cell.com
(1/15) Thrilled to share new Evo-Devo work where we address the molecular, cellular & morphometric basis of an extreme axis segmentation program in the Japanese eel — an animal that forms 120 vertebrae.
biorxiv.org
New Preprint alert!🚨 Super excited to share my postdoc work now on BioRxiv. How does PRC2 loss lead to developmental failures? We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬. Preprint: doi.org/10.64898/2026.04.18.719361
I am excited to announce that I have received a Travel & Merit Award for the #ISSCR2026 Annual Meeting about my work modeling mouse cranial and cardiac neural crest development in vitro. Many thanks to my mentor @tvierbuchen.bsky.social for his guidance and support throughout this project @ISSCR.org
I'm attending the ISSCR 2026 Annual Meeting, join me
Register now
invt.io
Congrats to @annbaako.bsky.social for her successful thesis defense!! @justinperryphd.bsky.social and I are so proud of you! Look out for a new version of Ann's manuscript on modeling tissue-resident macrophage development from mouse PSCs coming soon. www.biorxiv.org/content/10.1...
biorxiv.org
AP-1 is both night science and day science
Itai Yanai@itaiyanai.bsky.social · 4mo agoHow does a cell learn? In our new perspective in @nature.com we propose a model where the properties of the AP-1 family of transcription factors – stress-induced feedback, regulatory combinatorics and cellular memory – encode a mechanism for cellular learning. www.nature.com/articles/s41...
Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
biorxiv.org
For decades, molecular biology and human genetics have been built around measurements of average gene expression. That was partly conceptual, but also technological: for a long time, the mean was the quantity we could measure most reliably. Our new preprint argues that this framework is incomplete.
I'm so pleased to see this work on neural crest development out in Nature today! This was a truly fantastic collaboration with @gleesonlab.bsky.social, Keng loi (Harry) Vong and @xiaoxuyang.bsky.social. Huge thanks to everyone involved 👏 🧪🐣 #devbio www.nature.com/articles/s41...
Example #314: www.science.org/doi/10.1126/...
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory
Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood....
science.org
AP-1 TFs control everything, Example # 313 www.nature.com/articles/s41...
AP-1 mediates cellular adaptation and memory formation - Nature Communications
Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance v...
nature.com
👀 Absolute banger paper. Leveraging cattle/pig GWAS/eQTL to help explain the missing regulatory gap in humans. Consistent with previous works, selection makes identifying relevant eQTLs in humans challenging. www.biorxiv.org/content/10.6...
biorxiv.org
AP-1 transcription factors do everything, example #312. www.nature.com/articles/s41... www.nature.com/articles/d41...
Epigenetic memory of colitis promotes tumour growth - Nature
Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...
nature.com
Honoured and overwhelmed to receive the 2026 Waddington Medal. Science is a team effort, and I've been fortunate to work alongside exceptional people asking hard questions. Thank you to the BSDB and to everyone who has been part of the journey. bsdb.org/2026/03/24/2...
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
bsdb.org
Huge congratulations to James Briscoe @jamesbriscoe.bsky.social for receiving the 2026 BSDB Waddington Medal, recognising an extraordinary career of discovery, mentorship, and leadership in developmental biology. bsdb.org/2026/03/24/2...
2026 Waddington Medal Winner - James Briscoe - BSDB - British Society for Developmental Biology
We are very pleased to announce that this year’s Waddington medal winner is James Briscoe. His fundamental discoveries have helped shape our understanding of of how morphogens work, and he has played ...
bsdb.org
Really cool paper from Marie-Anne Felix's lab. Genetic variation in set-24 controls the duration of epigenetic inheritance. www.cell.com/current-biol...
Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans
Frejacques, Saglio, et al. demonstrate variation among C. elegans wild isolates in the multigenerational memory of an initial RNA interference trigger. Genetic polymorphisms and environmental variable...
cell.com
After 20 years, 58 generations and more than 30,000 cloning attempts, a team of researchers has hit the limit on the number of times a single mouse can be serially re-cloned go.nature.com/3Pue5Iz
Can a mouse be cloned indefinitely? Decades-long experiment has answers
Repeated cloning from a single mouse failed after 58 generations. Researchers say harmful DNA changes are to blame.
go.nature.com
BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses https://www.biorxiv.org/content/10.64898/2026.03.19.712964v1
One of my very favorite papers from the lab! Shows that individual cells can learn by forming memories. Amazing work by Jess Li!
Waggoner Lab@labwaggoner.bsky.social · 5mo agoAP-1 mediates cellular adaptation and memory formation @natcomms.nature.com @pennmedicine.bsky.social @arjunraj.bsky.social @penngenetics.bsky.social www.nature.com/articles/s41...
🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...
A dual role for CTCF in development
CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A
biorxiv.org
A Cooperative Mechanism of Eukaryotic Transcription Factor Target Search https://www.biorxiv.org/content/10.64898/2026.03.09.709760v1
JAX is proud to announce that Professor Bill Skarnes has been selected as the 17th recipient of the International Society for Transgenic Technologies (@transtechsociety.org) Prize, one of the highest honors in the field. 🧬 🧪
The Jackson Laboratory's Bill Skarnes wins top international prize in transgenic science
Skarnes' groundbreaking contributions to transgenic technologies and genome engineering made a generation of experiments possible
jax.org
