Blood cytotoxic NK-like CD8 + CD94+ T cells migrate to the brain and predict multiple sclerosis severity academic.oup.com/brain/advanc...

R version 4.6.1 "Happy Hop" (source version) has been released. It should be on CRAN by now (update of manuals pending). #rstats

barbieQ: an R software package for analysing barcode count data from clonal tracking experiments academic.oup.com/bioinformat...

3D multi-omics tumour atlases: from technology to biology and clinical translation www.nature.com/articles/s41...

3D multi-omics tumour atlases: from technology to biology and clinical translation - Nature Reviews Cancer

In this Review, Liu et al. describe the established and emerging tools for the generation of comprehensive 3D tumour atlases, the analysis of which has the potential to uncover novel biomarkers for ri...

nature.com

10/ That’s where Marimo comes in. A new tool that fixes Jupyter’s two biggest flaws: Git diff hell Execution chaos github.com/marimo-team...

GitHub - marimo-team/marimo: A reactive notebook for Python — run reproducible experiments, query with SQL, execute as a script, deploy as an app, and version with git. All in a modern, AI-native editor.

A reactive notebook for Python — run reproducible experiments, query with SQL, execute as a script, deploy as an app, and version with git. All in a modern, AI-native editor. - marimo-team/marimo

github.com

Fixed my Kinesis Advantage 1 choking on Linux kernels for the last few years. If you're on @nixos.org , add this to your config: boot.kernelParams = [ "usbcore.quirks=05f3:0081:mnc,05f3:0007:mnc" "usbcore.old_scheme_first=1" ];

and the video is up now: www.youtube.com/watch?v=wkjL...

Bruno Rodrigues: Reproducible Data Science with Nix

YouTube video by R in Pharma

youtube.com

R in Pharma@rinpharma.bsky.social · 3mo ago

The next R/Pharma Hangout is happening May 19th! @brodriguesco.bsky.social joins @rpodcast.bsky.social & Jared to share how Nix takes reproducibility in data science to brand new levels. Register for the event here: www.linkedin.com/events/r-pha... #rstats #nix

Like macrophages in general, Lipid-associated “foamy” 🚿macrophages come in different flavors. Here a new story on these big beauties in #multipleSclerosis Foamy microglia link oxylipins to disease progression in multiple sclerosis | @natneuro.nature.com www.nature.com/articles/s41...

Foamy microglia link oxylipins to disease progression in multiple sclerosis - Nature Neuroscience

Foamy microglia are associated with multiple sclerosis progression, linking phagocytosis, altered lipid metabolism (oxylipins) and lysosomal stress to nonclassical neuroinflammation and disease severi...

nature.com

My talk slides at the Nextflow Summit on reproducible bioinformatics is here divingintogeneticsandgenomics.com/files/slide...

R version 4.6.0 "Because it was There" (source version) has been released. It should be on CRAN by now. #rstats The choice of codename is in remembrance of R Core member Tomàš Kalibera (1978-2026). Among many other things, he was a keen mountain climber.

R 4.6.0 "Because it was There" is set for release on 24 April. @russhyde.bsky.social writes up the more interesting changes — %notin% in base R, neater character column summaries, and more. Full breakdown with code: www.jumpingrivers.com/blog/whats-n... #rstats #datascience #rprogramming

Introducing 🌳tarborist: a VS Code extension providing tree-sitter powered static analysis of {targets} pipelines with target info on hover, tar_map() autocompletion, cycle detection, and upstream/downstream info/links #RStats Github: github.com/tylermorganw... OpenVSX: open-vsx.org/vscode/item?...

New post on the @ropensci.org blog, "A Better R Programming Experience Thanks to Tree-sitter" Edited by @etiennebacher.bsky.social, @davisvaughan.bsky.social, Steffi LaZerte ropensci.org/blog/2026/04... #RStats

A Better R Programming Experience Thanks to Tree-sitter

Modern tooling for parsing, searching, formatting, editing R code, just like for other programming languages.

ropensci.org

rOpenSci@handle.invalid · 4mo ago

[blog] A Better R Programming Experience Thanks to Tree-sitter Did you know how Tree-sitter's support for R help you get ✨ reformatting through Air and linting through Jarl; ✨ auto-completion or help on hover in the Positron IDE; ✨ better search for R on GitHub; ✨ and more! By @maelle […]

#rstats I'm glad to announce Jarl 0.5.0! Jarl is a very fast R linter, written in Rust. This release brings many improvements and fixes. See the blog post: www.etiennebacher.com/posts/2026-0... And the full changelog: jarl.etiennebacher.com/changelog 🧵 to highlight some features below (1/4)

Most statistical tests you learned separately are the same thing. t-test, ANOVA, Mann-Whitney, Chi-square, Wilcoxon... all just special cases of linear models. y = b0 + b1*x covers almost everything.

Boris Cherny created Claude Code. Then he open-sourced his entire setup for using it. Memory files, subagents, skills, the whole thing. Here's what's inside and why you should steal it:

7 FREE Books to learn data science 🧵 👇 (not just bookmark, do read them) 1. Data science: A first introduction datasciencebook.ca/

I rounded up a few Claude Skills for #RStats users. Huge thanks to the creators who developed them. They share Skills for everything from tidyverse code to brand.yml files to learning while using AI. Hope the list is useful, and please let me know what I missed! 🧡 rworks.dev/posts/claude...

A Few Claude Skills for R Users – R Works

The community has come together to create some great Claude Skills that you can try out today.

rworks.dev

10 websites for drawing scientific figures 👇

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF | Nature Neuroscience www.nature.com/articles/s41...

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF - Nature Neuroscience

Verhaege et al. identify a conserved fibroblast barrier population at the base of the choroid plexus that compartmentalizes brain–CSF interfaces and is disrupted by inflammation, revealing a new site ...

nature.com

Overjoyed to share our new work exploring the antigen specificity of CSF-expanded CD8+ T cells in #multiplesclerosis #EBV in @natimmunol.nature.com #immunology 🧪🧵1/ www.nature.com/articles/s41...

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

nature.com

#RStats📦rix 0.17.4 is out! Major #Python QoL improvements: automatic LD_LIBRARY_PATH setup for easy integration with uv, new py_src_dir for editable-style Python dev in #Nix shells, and smarter cachix detection (no more noise on #NixOS). Plus docs cleanup & cache setup updates

Reproducible Polyglot Data Science still a WIP, but I think there's already quite a lot of useful content. Will stay free forever: reproducible-data-science.dev buy me an espresso to show your support: buymeacoffee.com/brodriguesco

1/2 For those working on multiple test correction in #Omics: repo: github.com/mihem/compar... result: www.mheming.com/compareFDP/ I’ve tried to benchmark BH against qvalue and permFDP. @tommytang.bsky.social

Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation: Immunity www.cell.com/immunity/ful...

Remodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation

Skull marrow communicates with the meninges through bone channels, yet their formation and regulation remain poorly understood. Eme-Scolan et al. show that these channels undergo active remodeling dur...

cell.com

Imo this package is a hidden gem. 💎 I’m no statistician, but the logic is solid. With many variables, I got different results than BH—it seems to find signals that standard corrections miss github.com/steven-shuke... @tommytang.bsky.social @brodriguesco.bsky.social what do you think?

GitHub - steven-shuken/permFDP: An R package for correcting p-values for multiple hypothesis testing in comparative quantitative omics experiments using permutation-based FDP estimation.

An R package for correcting p-values for multiple hypothesis testing in comparative quantitative omics experiments using permutation-based FDP estimation. - steven-shuken/permFDP

github.com

Depending on your data type, use the right plot to tell the story. A nice interactive app to determine what plots you need www.data-to-viz.com/

#rstats Please welcome Jarl, a new R linter. Jarl is a CLI tool with extensions in VS Code, Positron, and Zed. It can check thousands of lines of R code in milliseconds. Jarl provides several output formats, a Github Actions workflow, and more. Blog post: www.etiennebacher.com/posts/2025-1...

This gives a fantastic framing of how to think about reproducibility (it's a spectrum) and how to use renv with intention. Highly recommend, even if you're not using renv, to get a better understanding of how to live in peace as R and package versions advance 🕊️ #rstats

Shannon Pileggi@pipinghotdata.com · 9mo ago

The recording of my #rstats posit::conf talk ✨ practical {renv}✨ is available! 🎉 I created this talk for frustrated {renv} users 🫠 and potential {renv} users🤩 youtu.be/l01u7Ue9pIQ?... Even if {renv} isn't on your radar, you may still find this talk interesting if you are curious about🤔...

Announcing Agent HQ in VS Code: a unified agent experience directly in the editor. Here's what that looks like...🧵