This new @michellemonje.bsky.social preprint shows that #psilocybin promotes the rapid and persistent growth of... xenografted glioma in mice. 🫠 www.biorxiv.org/content/10.6... Enduring but maladaptive plasticity induced by #psychedelics. h/t @tylerekins.bsky.social @theborislab.bsky.social

Next-gen neuroplastogen developers be like

“Approval rates significantly declined from 2022 to 2024 [...] In 2022, 74 of the 90 (82%) requests were approved, followed by 123 out of 165 (74.5%) in 2023 and 107 out of 181 (59.1%) in 2024, even though the number of overall requests remained stable.” www.nature.com/articles/s44...

This Is Your Priest on Drugs?

One of my favorite resources & collaborative opportunities for those interested in the psychedelic field!! Amazing work!!

josh hardman@josh-hardman.bsky.social · last yr.

📚✨ ~500 Papers. ~30 Researchers & Experts. One Annotated Psychedelics Bibliography... Very excited to share the 2024 edition of Psychedelic Alpha's Interdisciplinary Annotated Psychedelic Research Bibliography, by @michaelhaichin.bsky.social. psychedelicalpha.com/news/the-int...

3 of my papers (2 preprints) made the list! Great resource and great for scoping out all that was published last year

josh hardman@josh-hardman.bsky.social · last yr.

📚✨ ~500 Papers. ~30 Researchers & Experts. One Annotated Psychedelics Bibliography... Very excited to share the 2024 edition of Psychedelic Alpha's Interdisciplinary Annotated Psychedelic Research Bibliography, by @michaelhaichin.bsky.social. psychedelicalpha.com/news/the-int...

📚✨ ~500 Papers. ~30 Researchers & Experts. One Annotated Psychedelics Bibliography... Very excited to share the 2024 edition of Psychedelic Alpha's Interdisciplinary Annotated Psychedelic Research Bibliography, by @michaelhaichin.bsky.social. psychedelicalpha.com/news/the-int...

The Interdisciplinary Annotated Psychedelic Research Bibliography of 2024 - Psychedelic Alpha

Psychedelic Alpha’s Medical Advisor, Michael Haichin, compiled a list of over 500 notable psychedelics-related publications from 2024. He then presented it to a group of researchers from varying…

psychedelicalpha.com

Got interviewed by the Microdose newsletter on the intersection of #psychedelic and #placebo research and on why psychedelic research should revisit the long forgotten Zelen design to solve the "know-cebo" problem. Enjoy! themicrodose.substack.com/p/the-power-...

The power of “know-cebo”: 5 Questions for data scientist Balázs Szigeti

Szigeti discusses expectancy effects, unblinding, and how researchers might design better studies on psychedelics.

themicrodose.substack.com

Our new review in JAMA Psychiatry: "Expectancy Effects, Failure of Blinding Integrity, and Placebo Response in Trials of Treatments for Psychiatric Disorders" jamanetwork.com/journals/jam... Thanks to co-first author Guil Fusetto-Veronesi; and to Samuele Cortese, David Baldwin, Matt Garner 🧵👇

Expectancy Effects, Blinding Integrity, and Placebo Response in Psychiatric Disorders

This narrative review discusses the impact of expectancy effects and functional unblinding on treatment responses in randomized clinical trials of treatments in psychiatry.

jamanetwork.com

New: The Q1'25 Edition of our Psychedelic Drug Development Pipeline Bullseye Chart is now available to download. Get an overview of psychedelic candidates by molecule type and phase of development via this handy visual. psychedelicalpha.com/news/q125-ps...

Q1’25 Psychedelic Drug Development Pipeline: Bullseye Chart - Psychedelic Alpha

We present the psychedelic drug development pipeline in a ‘bullseye chart’ format, as of Q1’25.

psychedelicalpha.com

Psychedelic mental health research is booming—but how do we keep up with rapidly evolving evidence? 🌱 Our team proposes a living evidence synthesis approach to ensure clinicians, policymakers, and the public have access to the latest, most reliable data. 🔗 www.nature.com/articles/s44... 🧪🧵

5x5 for 2024 What were your 5 favourite albums, books, movies, podcasts, and TV shows this year? See below for mine, in no particular order. Quote this post and tell me yours!

"Navigating this new world will require a more precise understanding of the psychoactive substances that are now part of it. Instead of attempting to sort chemical compounds into good and bad, we could pay more attention to how people use them." - @mikejay.bsky.social www.nytimes.com/2024/12/23/o...

Opinion | As Drug Culture Becomes Mainstream, Our Language Needs To Evolve. (Gift Article)

We need a new language to talk about the chemicals and plants that change our consciousness.

nytimes.com

Thought-provoking chapter about the integration of psychedelics into society: academic.oup.com/book/58175/c... TL;DR 10-year trial period privately funded w/ a new type of insurance and only two doses of psilocybin per year per adult available in protected spaces following psychiatric screening.

I spoke with Javier Muniz, MD, who just left his role as Associate Director at FDA's Division of Psychiatry, about all things psychedelics. psychedelicalpha.com/news/inside-...

Inside the FDA’s Psychedelics Journey: Javier Muniz, MD on Breakthroughs, Challenges, and the Future of the Field - Psychedelic Alpha

In our latest Pα+ interview, our Editor Josh Hardman speaks with Javier Muniz, MD, who recently left his post as Associate Director at the FDA’s Division of Psychiatry. In that role, Muniz was at the…

psychedelicalpha.com

Another NMDA antagonist for depression bites the dust… Is it still a viable target?

New paper! This was a fun lil collaboration with Maastricht University in which we thought we might find evidence that ayahuasca would increase false memory in an observational study. WRONG! Ended up enhancing memory (but read 'til end for caveats) journals.sagepub.com/doi/10.1177/... 1/8

Sage Journals: Discover world-class research

Subscription and open access journals from Sage, the world's leading independent academic publisher.

journals.sagepub.com

Psychoactive-controlled ketamine for OCD study doi.org/10.1177/0269... "We did not assess blinding...prominent differences in dissociation scores...suggest that fentanyl 50 μg also did not provide an adequate blind...would not recommend its use (but do not have a suitable alternative to recommend)."

Psychoactive-controlled ketamine for OCD study doi.org/10.1177/0269... "We did not assess blinding...prominent differences in dissociation scores...suggest that fentanyl 50 μg also did not provide an adequate blind...would not recommend its use (but do not have a suitable alternative to recommend)."

Benjamin Labatut is one of the most amazing writers I’ve ever read! If you haven’t, please check “The day we ceased to understand the world” and “Maniac” His interviews are also mind blowing: youtu.be/E-OFnHwuTBg?...

"Anything that comes out of a writer is fiction." | Writer Benjamín Labatut | Louisiana Channel

YouTube video by Louisiana Channel

youtu.be

A new preprint for my new BlueSky homies: "Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically" www.researchgate.net/publication/...

(PDF) Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically

PDF | Background: Psychedelic drugs show promise in facilitating a variety of long-term psychological changes, but they may also lead to unexpected... | Find, read and cite all the research you need o...

researchgate.net

I don't know who made this #psychedelics paper one but I love it so much I framed a copy for my office

Matthijs Dorst@mattneuro.dorst-lab.org · 2y ago

Didn't see one for Neuroscience yet; allow me to oblige

Hi 🦋 1) Medical Advisor to Psychedelic Alpha 2) 2024 Interdisciplinary Annotated Psychedelic Research Bibliography (psychedelicalpha.com/news/2023-an...) - let me know if you'd like to participate 3) Just finished There's Always This Year - the most beautifully written non-fiction I've come across

The Interdisciplinary Annotated Psychedelic Research Bibliography of 2023 - Psychedelic Alpha

Psychedelic Alpha’s Medical Advisor, Michael Haichin, compiled a list of over 500 notable psychedelics-related publications from 2023. He then presented it to a group of researchers from varying…

psychedelicalpha.com

josh hardman@josh-hardman.bsky.social · 2y ago

Bluesky Psychedelics People: Let's (re-)intro ourselves to one another! Quote this post and tell us: 1) What you do in the field 2) A project you're currently working on 3) A show/film/book you're enjoying