Awesome new work by @tsalo.bsky.social and @parkersingleton.bsky.social — a small but valuable test-retest dataset comparing single & multi-echo fMRI. Completely open + fully processed!!!!

PennLINC@pennlinc.bsky.social · 4w ago

New dataset out in Data in Brief 🧠 We're releasing an open, test-retest neuroimaging dataset built for directly comparing single-echo vs. multi-echo fMRI, head-to-head, in the same people. 1/

New dataset out in Data in Brief 🧠 We're releasing an open, test-retest neuroimaging dataset built for directly comparing single-echo vs. multi-echo fMRI, head-to-head, in the same people. 1/

A single-echo/multi-echo BOLD fMRI test-retest dataset

Functional MRI (fMRI) remains one of the primary tools for non-invasive studies of brain activity and organization in humans. Recently, multi-echo ima…

sciencedirect.com

Here's bonus slides on cross-validation tests, separate from our preprint. Covering: 1. paired (sign-flip) permutation test 2. label-swap permutation test 3. sample-level vs fold-averaged stats 4. a common misapplication of the corrected t-test 5. three bootstrap variants 1/N

Thomas Yeo@bttyeo.bsky.social · 3mo ago

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

Nice article on our recent Nature Mental Health paper: www.medscape.com/viewarticle/...

‘Living’ Database Tracks Psilocybin Trials for Depression

Sypres.io continuously tracks and evaluates psychedelic research, offering an up-to date view of study findings, design, and limitations.

medscape.com

Thrilled to share our latest paper, out recently in Nature Mental Health. "Optimizing functional connectivity scanning conditions for predicting autistic traits" www.nature.com/articles/s44... 1/n

Optimizing functional connectivity scanning conditions for predicting autistic traits - Nature Mental Health

This research investigates optimal brain states for predicting autistic traits using connectome-based predictive modeling across four datasets. Findings indicate that a sustained attention task enhanc...

nature.com

Corey Horien@coreyhorien.bsky.social · 2y ago

Take a look at some of our latest results, diving into task-fMRI data, autism, and predictive modelling: "What is the best brain state to predict autistic traits?" www.medrxiv.org/content/10.1... 1/2

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development. 🔗 www.biorxiv.org/content/10.6...

Incredible work by the absolutely stellar @bsevchik.bsky.social and @parkersingleton.bsky.social — the second installment of our open-science living meta-analysis of psychedelics for mental health.

Brooke Sevchik@bsevchik.bsky.social · 4mo ago

🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵 www.medrxiv.org/content/10.6...

And here's our second installment of sypres.io, co-led by the brilliant @bsevchik.bsky.social !!

Brooke Sevchik@bsevchik.bsky.social · 4mo ago

🍄 Our new living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵 www.medrxiv.org/content/10.6...

This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration." www.nature.com/articles/s41...

An international mega-analysis of psychedelic drug effects on brain circuit function - Nature Medicine

Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.

nature.com

Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at @natmentalhealth.nature.com. Check out Parker's awesome thread below, w/ links to dashboard + all code + data.

Parker Singleton@parkersingleton.bsky.social · 4mo ago

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

Excited that this is officially out there in the world. Check out the dashboard and visualizations! Huge shout out to Parker and Brooke, who led this herculean effort. More to come!

Parker Singleton@parkersingleton.bsky.social · 4mo ago

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

hello

boop

What makes brains (un)conscious? We provide new answers—and a universal mammalian blueprint for information processing—in a cross-species study of humans, macaques, marmosets & mice. Exploring convergent breakdown of integration in: www.nature.com/articles/s41... Led by @loopyluppi.bsky.social

Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains - Nature Human Behaviour

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia in humans, macaques, marmosets and mice.

nature.com

Happy to have been a part of yet another tour de force led by the one and only @loopyluppi.bsky.social !

Andrea Luppi@loopyluppi.bsky.social · 5mo ago

The Mammalian Architecture of Information Integration🧠🧬 For #BrainAwarenessWeek, excited to share our latest work about #Neuroscience of #Consciousness in @nathumbehav.nature.com www.nature.com/articles/s41... 🧵👇

The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi. To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6... youtube.com/shorts/MryMq...

how does his brain do it ? #neuroscience #memory #sport Nelson Dellis 6x US memory champion

YouTube video by Roselyne Chauvin

youtube.com

Very happy that this paper from our lab is now out in @pnas.org! What happens when the *same* person experiences the *same* information with a *different* interpretation? Nearly the whole 🧠—well, at least nearly all association cortex—changes how it represents that information! tinyurl.com/p8chj2j7

🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization. But is it actually the best way to estimate functional architecture? We tested this directly. 🧵1/8

We think of white matter as the highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My final PhD paper, “Two Axes of White Matter Development”, is now out in @natcomms.nature.com! 🛣️🧠✨ 🔗 bit.ly/wm2axes

Every participant had a MEQ-30 score of 150: youtu.be/-c9-poC5HGw?...

Africa - Angel City Chorale

YouTube video by Angel City Chorale

youtu.be

My first preprint is out! Thank you to my brilliant collaborators & mentors for making this possible @vmarchman.bsky.social @arokem.org @jyeatman.bsky.social, as well as everyone behind the awesome open source software that we use @pennlinc.bsky.social @cieslakmatt.bsky.social (& many not on bsky)

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 6mo ago

Neonatal brain-age models in full- and preterm infants https://www.biorxiv.org/content/10.64898/2026.01.23.701337v1

My Neighbour Totoro is I think the only movie I can think of that has a compelling plot for kids that does not involve a villain.

Another important one for psychedelics fMRI ppl: www.biorxiv.org/content/10.6...

Physiological Arousal as a Predominant Source of Individual Differences in Functional Brain Networks

Individual differences in brain network function and organization are promising targets for fMRI-based biomarkers in precision psychiatry, yet the sources of individual variability remain poorly under...

biorxiv.org

Come join an amazing team where you're guaranteed to set yourself up for future success!

Ted Satterthwaite@ted-satterthwaite.bsky.social · 8mo ago

#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs. Website: www.pennlinc.io Job: bit.ly/4ojvCir

💊 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.

🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550 www.biorxiv.org/content/10.1...

After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:

Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications

The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...

biorxiv.org

Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA 10.1093/brain/awaf391