Are psychedelics anti-inflammatory? A systematic review and meta-analysis of studies examining the immunomodulatory effects of serotonergic psychedelics

Serotonergic psychedelics are promising treatments for neuropsychiatric disorders, and their immunomodulatory effects may contribute to their clinical…

sciencedirect.com

jmepb.bmj.com

Evaluating the evidence for repressed memory recovery in psychedelic contexts - Psychopharmacology

Rationale Reports of resurfaced repressed memories during psychedelic experiences have circulated for decades and still emerge today. However, the veracity of repressed memories remains debated, and the mechanisms through which psychedelics might recover alleged repressed memories are unclear. Objectives This scoping review aimed to provide an overview of the literature on repressed memory in the context of psychedelics. It examined how repressed memory was defined, which substances were predominantly discussed, which mechanisms were proposed to explain their effects, and whether these mechanisms were empirically supported. Methods A scoping review was conducted in line with PRISMA-ScR guidelines. Web of Science, PubMed, PsycINFO and Google Scholar were searched for relevant publications. Fifty-three sources met eligibility criteria. Data were charted on study design, psychedelic substance, definitions of repressed memory, results, and proposed mechanisms. Results Most publications focused on lysergic acid diethylamide (LSD) in relation to repressed memory. Few sources provided a definition of repressed memory. Proposed mechanisms on how psychedelics might influence repressed memory included psychoanalytical reductions of defensive memory blockades and neurobiological alterations of executive control. However, empirical support for these mechanisms was limited. Conclusions The included literature did not offer a coherent explanation on how psychedelics could recover repressed memories, nor consistent evidence that they did so reliably. Future work should provide clear definitions of repressed memory in the context of psychedelics, test proposed effects of psychedelics on memory and executive control across multiple psychedelic substances, include placebo-controlled designs, and account for the potential occurrence of false memories.

doi.org

Preliminary effects of ayahuasca on mental and physical health: A systematic review of prospective studies

Ayahuasca is a psychedelic plant brew that has been used in Central and South America for centuries. Recently, there has been an increase in “drug tou…

sciencedirect.com

Best practices for first psychedelic experiences: harm reduction advice from the psychedelic community - Harm Reduction Journal

Background The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number o...

link.springer.com

Single-dose psychedelic enhances cognitive flexibility and reversal learning in mice weeks after administration

Psychedelic compounds have demonstrated remarkable therapeutic potential for treating neuropsychiatric disorders by promoting sustained neuroplasticity in the prefrontal cortex (PFC). Cognitive flexib...

pmc.ncbi.nlm.nih.gov

Psychedelic-assisted psychotherapy: where is the psychotherapy research? - Psychopharmacology

Rationale Psychedelic-assisted psychotherapy (PAP) has emerged as a potential treatment for a variety of mental health conditions, including substance use disorders and depression. Current models of P...

link.springer.com

Opinion | How the American Right Learned to Love Psychedelics (Gift Article)

A once left-wing psychedelic movement has become tightly entwined with the Trump administration.

nytimes.com

Addressing blinding in classic psychedelic studies with innovative active placebos

AbstractRationale. Classic psychedelics show promise as a treatment for various neuropsychiatric disorders. However, weak blinding integrity in trials has

academic.oup.com

Understanding experiences with psychedelics

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

umich.qualtrics.com

Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview

Psychedelic substances are increasingly recognized for their potential to catalyse transformative shifts in worldviews. Central to these transformations are states of awe, a self-transcendent, epistem...

doi.org

Frontiers | Preliminary safety and effectiveness of psilocybin-assisted therapy in adults with fibromyalgia: an open-label pilot clinical trial

frontiersin.org

Tripping into Treatment: Comparing Initial and Current Motivations for Psychedelic Use

Psychedelic drugs are currently being explored for their therapeutic potential for a variety of health conditions. The recent increased public interest in psychedelics necessitates empirical invest...

tandfonline.com

Billionaire Investor Antonio Gracias Plots $100M Lykos Takeover with Doblin’s Backing - Psychedelic Alpha

This latest twist in the Lykos Therapeutics saga threatens a major overhaul of the company’s strategy and direction, with Musk ally and billionaire investor Antonio Gracias appearing to want to take…

psychedelicalpha.com

Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials

This narrative review describes clinical trials of psychedelic or MDMA therapy and reports from the investigators on the use of modifications to informed consent in these studies.

jamanetwork.com

Inside the FDA’s Psychedelics Journey: Javier Muniz, MD on Breakthroughs, Challenges, and the Future of the Field - Psychedelic Alpha

In our latest Pα+ interview, our Editor Josh Hardman speaks with Javier Muniz, MD, who recently left his post as Associate Director at the FDA’s Division of Psychiatry. In that role, Muniz was at the…

psychedelicalpha.com

(PDF) Major life changes following psychedelic use: A retrospective survey among people using psychedelics naturalistically

PDF | Background: Psychedelic drugs show promise in facilitating a variety of long-term psychological changes, but they may also lead to unexpected... | Find, read and cite all the research you need o...

researchgate.net