Mikel Lavilla-Puerta
@mikellavi.bsky.social
Oxygen, yeast, SynBio and sometimes, plants. Postdoc at Oxford Biology, PhD at Scuola Superiore Sant'Anna. I also sing and am very fond of my village.
We knew PCOs & ERFVIIs regulated plant hypoxia, but this work shows they also manage the 'reoxygenation' stress. www.nature.com/articles/s41... @biology.ox.ac.uk @ox.ac.uk @uni-muenster.de
H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses - Nature
Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergen...
nature.com
The big takeaway: these O2 sensing systems are functionally interchangeable across kingdoms, but they're not identical. The kinetic differences matter!
New paper out from the Synoxys lab! We asked an important question: what if plants sensed oxygen like animals do? what if we swapped the O2 sensing across? We built the system to find out. 🧵 www.nature.com/articles/s41... #plantscience @syno2xis.bsky.social @beagiuntoli.bsky.social @biology.ox.ac.uk
a poster for indiana jones and the last crusade with a man in a hat
ALT: a poster for indiana jones and the last crusade with a man in a hat
media.tenor.com
It's finally out! With this new paper, Salma and Monica show that hypoxia-regulated ERFVIIs are not immediately destabilised during reoxygenation: they instead persist in the nucleus to control oxidative stress genes. www.nature.com/articles/s41...
When oxygen drops, plants respond in minutes 🌱 Oxford @biology.ox.ac.uk's @mikellavi.bsky.social and @syno2xis.bsky.social + Engineering Science researchers, with Prof Antonis Papachristodoulou, reveal a circuit key to plant survival. 🔗 eng.ox.ac.uk/news/without...
Very happy to see this out!! Thank you all! Check out or latest publication www.pnas.org/doi/10.1073/...
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...
pnas.org
Oxford Biology@biology.ox.ac.uk · 5mo agoWithout oxygen, the first minutes matter 🌱 In low oxygen, eg when flooded, plants need to act quickly to survive. New research led by @mikellavi.bsky.social has revealed a molecular circuit that kicks into gear in minutes - and it can work completely independently 👇
Without oxygen, the first minutes matter 🌱 In low oxygen, eg when flooded, plants need to act quickly to survive. New research led by @mikellavi.bsky.social has revealed a molecular circuit that kicks into gear in minutes - and it can work completely independently 👇
Without oxygen, the first minutes matter: a molecular circuit helps plants survive
bit.ly
What features are required to shape hypoxic niches enclosing meristems? We @viktoriiavoloboeva.bsky.social in collab @pieterverboven.bsky.social found that a combination of cuticle barrier, densely packed tissue and metabolic activity all uniquely contribute to maintain shoot apical meristem hypoxia
Finally officially out!! www.pnas.org/doi/10.1073/... We moved the main oxygen sensing machinery from plants to yeast and we learned a few things!
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...
pnas.org
Surprisingly: "Conditional stability of HY5 through the ATE N-degron pathway regulates environmental responses in Arabidopsis thaliana". The shining bounds of N-degron pathway influence expands! @charlene-kunaka.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
🚨 Positions available in Plant Science! Please share. We’re hiring: 1. Postdoc 2.PhD (UK applicants only) Focus: root oxygen dynamics, developmental signalling. Come help us uncover how O2 shapes root development. More info here- sites.google.com/view/root-re... #plantscijobs #plantscience
#ThrowbackThursday to last week Thursday at #ISPLORE2025JP where we took a group picture of our fantastic community. Missing those conferences vibes? Scroll back through the #ISPLORE2025JP hashtag for some of the best moments 🌱🌊
#ISPLORE2025JP is over.. but not before a comedy performance and closing ceremony by the organizers Mikio Nakazono and Moto Ashikari 😆 Thanks so much to all organisers and sponsors for making this edition possible. It was truly amazing! Next edition reveal by @djgibbs.bsky.social: #ISPLORE2028UK
Coming to you live from #ISPLORE2025JP Fresh preprint from my lab showing that leaves progressively oxygenate and how this is important for their morphogenesis.Thanks to our collaborators from @Fra_LicO2si lab. #plantscience www.biorxiv.org/content/10.1...
We finish this #ISPLORE2025JP session with exceptional talks by @mikellavi.bsky.social, Daai Zhang, @vinayshukla.bsky.social and Lina Zhou 🌱🌊 Check out @beagiuntoli.bsky.social's recent preprint #plantscience www.biorxiv.org/content/10.1...
The speed of hypoxia: great talk by @mikellavi.bsky.social at the @isplore.bsky.social conference in Nagoya!
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional ada...
biorxiv.org
Preprint alert! 🗞 We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄. We can now control yeast growth through oxygen! But most importantly, Here's a very short recap of what we understood thanks to it: biorxiv.org/content/10.110…
a cartoon of spongebob wearing a hat with the letter f on it
ALT: a cartoon of spongebob wearing a hat with the letter f on it
media.tenor.com
“I come from a rural area where agriculture and natural spaces coexist.” academic.oup.com/plphys/artic... #WeAreASPB
Honoured & excited that ‘Breathing Underground’ has been funded by the ERC! This will let me explore one of the most fundamental questions of plant life: how roots breathe underground? @erc.europa.eu
The January 2025 issue of Plant Physiology is now online! Read this Focus Issue on Hypoxia and Plants here: https://academic.oup.com/plphys/issue @ASPB @OxUniPress #PlantSci
The diverse aspects of hypoxia. The size of the oxygen bubble correlates with concentration. This collection highlights the importance of hypoxia for plant development and environmental adaptation such as during flooding, in compacted or poorly aerated soils, high altitudes, and within meristematic tissues. Image credit: Moe Abbas.
academic.oup.com
The real deal on the topic of plant hypoxia, SynBio and orthogonality. How to use these three concepts to build new oxygen-sensitive circuits? Don't miss the thread below!
Vinay Shukla@vinayshukla.bsky.social · 2y agoPreprint alert, please share!! With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
Preprint alert, please share!! With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
Added many more ISPLORE researchers to our starter pack, including @theplantlab.bsky.social, @mikellavi.bsky.social @freddietheodoulou.bsky.social, @gunjansharma88.bsky.social. Welcome to BlueSky!
First Bluesky post to share our review with the world! Is there anything, beyond oxygen biosensors, that SynBio can provide to the world of plant hypoxia? Check it out here! @plantphys.bsky.social academic.oup.com/plphys/advan...
Designed to breathe: synthetic biology applications in plant hypoxia
Novel biosensors and concepts from engineering biology expand the toolbox for plant low oxygen biology research
academic.oup.com