More on NAC and cotranslational Nt-acetylation by NatB. Congratulations to the first authors Natalia and Pawel! rdcu.be/ftSay

Structural basis of cotranslational protein N-terminal acetylation by NatB in human cells

Nature Communications - N-terminal acetylation is one of the most common protein modifications. Here, the authors show how NAC recruits the essential enzyme NatB to translating ribosomes, revealing...

rdcu.be

α-Synuclein N-terminal acetylation tunes both its structural and physicochemical properties to enhance binding to lipid bilayers @ispt-proteinterm.bsky.social pubs.acs.org/bichaw/artic...

N-Terminal Amine Chemistry Influences α-Synuclein Interactions with Lipid Bilayers

Abstract. α-Synuclein (αSyn) is an intrinsically disordered protein whose reversible membrane binding via amphipathic α-helix formation is central to its f

pubs.acs.org

Our new preprint shows that metacaspase-mediated proteoform generation and N-degron pathway-dependent proteoform stability act together to diversify UBP6 function during Arabidopsis immunity www.biorxiv.org/content/10.6...

Functional diversification of UBP6 in plant immunity through N‑degron pathway regulation

Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modifications on substrate proteins, including those target...

biorxiv.org

Structural and mechanistic insights into the UBR4-KCMF1-Calmodulin complex @ispt-proteinterm.bsky.social academic.oup.com/proteincell/...

Structural and mechanistic insights into the UBR4-KCMF1-Calmodulin complex

Dear Editor,

academic.oup.com

After a wonderful four day, @giglionelab.bsky.social wraps up #proteintermini2026 Grazie, Carmela for a fantastic meeting and we look forward to Heidelberg in 2028!

Well, the conference dinner is absolutely hellish #proteintermini2026

As predicted, the food at #Proteintermini2026 is delicioso! Trying hard to resist these ricotta-filled pastries with candied orange

Look out for @jxbotany.bsky.social and @febsletters.bsky.social special issues on all things related to #Proteintermini2026

Have you ever seen a poster session like this? Simply beautiful. #Proteintermini2026

And we’re off! @giglionelab.bsky.social introduces FEBS Workshop #Proteintermini2026 Looking forward to four days of great science

#Proteintermini2026 is about to begin! This beautiful room in the heart of Palermo will be our home for the next four days 🤩

A conference about #proteostasis in a palazzo in Palermo; inclusive, affordable, and organised by the marvellous @giglionelab.bsky.social - what’s not to like? Oh, and there is a fantastic lineup of talks plus slots to spare #ProteinTermini2026

International Society for Protein Termini (ISPT)@ispt-proteinterm.bsky.social · 9mo ago

See you at Palazzo dei Normanni in Palermo for the 2026 Protein Termini Conference | Co- and post-translational modifications | Proteolytic processing and degradation pathways | Microbes, plants, animals #ProteinTermini2026 #Proteostasis #ProteinModifications #PalazzoDeiNormanni #Palermo2026

Excited to co-organize the upcoming FASEB Science Research Conference (SRC) on Protein Lipidation: Enzymology, Signaling, Therapeutics! July 13-15, 2026. Where: Yours Truly DC Hotel | Washington, DC. Register & Submit your abstract here: events.faseb.org/event/protei... Deadline Extended!

The countdown to Palermo is on! 🇮🇹 The FEBS Workshop "Protein Termini 2026" is set. • 151 participants from all over the world. • >50% ECRs! • 30+ travel grants. Thx to sponsors: FEBS, IUBMB, CDBC, ARS, and others.. See you at Palazzo dei Normanni! #ProteinTermini #FEBS #Proteostasis

An N-Acetyltransferase-MAPK fusion protein modulates developmental reprogramming in Physcomitrium patens 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... by de Luxán-Hernández et al. @moodytomato.bsky.social @plantophagy.bsky.social @eleazarrodriguez.bsky.social @WileyPlantSci #PlantScience

New review out on protein N-terminal formylation - a stress-inducible modification of eukaryotic proteins #N-degron @ispt-proteinterm.bsky.social www.nature.com/articles/s12...

N-terminal formylmethionine as a degron and a specific signal in proteostasis and stress adaptation - Experimental & Molecular Medicine

N-terminal methionine formylation, a protein modification once thought to be exclusive to bacteria and organelles, also occurs on proteins synthesized in the cytosol of yeast and human cells, challeng...

nature.com

So happy and proud to share our lab’s first #plantscience research article, revealing that angiosperms have the capacity to encode memory of flooding stress. A heroic effort by @aidamaric.bsky.social in collaboration with @djgibbs.bsky.social and others. A brief 🧵 www.biorxiv.org/content/10.6...

N-terminal cysteine dependent proteolysis of RGS4/5 is not sensitive to physiological oxidative stress | Preprint by Ya-Min Tian, Haeun Kim, Peter Ratcliffe & Thomas Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron #cysteine www.biorxiv.org/content/10.6...

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation www.pnas.org/doi/10.1073/...

A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation | PNAS

The Arg/N-degron pathway of Saccharomyces cerevisiae is mediated by two interacting E3 ubiquitin ligases, Ubr1 and Ufd4. We show here that the mito...

pnas.org

Resistance to prolonged darkness in plants steered by N-terminal acetylation | New study by Gong et al. Markus Wirtz lab @giglionelab.bsky.social Tanja Bange lab #NatB #autophagy #N-degron #proteostasis www.nature.com/articles/s41...

The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications

Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...

nature.com

How are histones acetylated as they emerge from the ribosome? We show that NAA40 cooperates with the NAC complex to enable co-translational acetylation of H2A/H4, revealing NAC as a coordinator of nascent protein modification. Read more about our collaboration with @kirmizislab.bsky.social #cryoEM

NAA40 and NAC cooperate in co-translational histone acetylation in humans

Nature Communications - N-terminal histone acetylation by human NAA40 alters epigenetic signaling and affects gene regulation. Here, the authors combine biochemistry and cryo-EM to unravel the...

rdcu.be

Finally officially out!! www.pnas.org/doi/10.1073/... We moved the main oxygen sensing machinery from plants to yeast and we learned a few things!

A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS

Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...

pnas.org

My review “Co-translational control of protein stability and quality in plants” is now online at @jxbotany.bsky.social, in which I describe how co-translational processing and ribosome-associated quality control together establish protein stability and fate early in synthesis. tinyurl.com/5dhhz9h6

Co-translational control of protein stability and quality in plants

Abstract. Proteostasis relies on the coordinated control of protein synthesis, folding, modification and degradation, and an increasingly clear picture is

tinyurl.com

Actin N-terminal maturation can be blocked by a butynamide stereoprobe which acts as an ACTMAP inhibitor. Preprint by Xiong et al. Benjamin Cravatt and Bruno Melillo. @ispt-proteinterm.bsky.social www.biorxiv.org/content/10.6...

Join us in Palermo! FEBS Workshop Protein Termini 2026: the power of protein termini across bacteria, plants, and animals—from ribosome biology to proteostasis and applications. Deadline: 3 March 2026 proteintermini.org/meeting #ProteinTermini #Proteostasis #FEBS #EMBO @iubmb.bsky.social

Join us at the @crick.ac.uk for the 2026 meeting of the UK proteostasis community! We especially encourage students and postdocs to attend and share their work. All talks (except the keynotes) will be selected from abstracts.

Proteostasis UK@proteostasisuk.bsky.social · 6mo ago

📣 UK Proteostasis Meeting 2026 – Registration Now Open! I’m delighted to share that registration is now open for the UK Proteostasis Meeting 2026, hosted by The Francis Crick Institute on 20–21 July 2026
. Please register here(lnkd.in/ervXMzWN) and through Eventbrite for payment (lnkd.in/eTxqjnQy)

Surprisingly: "Conditional stability of HY5 through the ATE N-degron pathway regulates environmental responses in Arabidopsis thaliana". The shining bounds of N-degron pathway influence expands! @charlene-kunaka.bsky.social www.biorxiv.org/content/10.6...