In memory of Professor Tamara Vasilievna Chirkova (1932 -2026). She pioneered research on plant adaptation to oxygen deficiency and laid a robust foundation for the advancements we witness today. #plantscience sites.google.com/ucr.edu/ispl...
Functional diversification of UBP6 in plant immunity through N-degron pathway regulation https://www.biorxiv.org/content/10.64898/2026.07.24.740541v1
Our new preprint shows that metacaspase-mediated proteoform generation and N-degron pathway-dependent proteoform stability act together to diversify UBP6 function during Arabidopsis immunity www.biorxiv.org/content/10.6...
Functional diversification of UBP6 in plant immunity through N‑degron pathway regulation
Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modifications on substrate proteins, including those target...
biorxiv.org
New preprint: In collaboration with @yorgsvicen.bsky.social we show metacaspase9 and ATE N-degron pathway-dependent proteoform stability act to diversify UBP6 function during plant immunity www.biorxiv.org/content/10.6...
Functional diversification of UBP6 in plant immunity through N‑degron pathway regulation
Deubiquitylases are key proteolytic regulators of ubiquitin-dependent cellular processes, catalyzing the removal or remodelling of ubiquitin modifications on substrate proteins, including those target...
biorxiv.org
We developed genetically encoded FRET-based biosensors to visualize protease activity in living plant cells with high spatial and temporal resolution. (2/5)
Today marks a huge milestone in my career. I am proud to be announced as one of the new BBSRC Discovery Fellowship awardees, with a grant close to the value of £500 000
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
Over the last month I saw that human editors are now stripped of control. I could no longer stop the system from auto-inviting "reviewers" with zero relevant expertise. Even worse - the AI began actively revoking the invitations I manually sent out to actual, qualified experts.
Cool new T-DNA plasmid! Let's see how it gets adopted and common tools become available -- hope those will happen to some level at least www.biorxiv.org/content/10.6...
Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana
Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, u...
biorxiv.org
The final version of our @annualreviews.bsky.social article is now published OPEN ACCESS www.annualreviews.org/content/jour...
In Vivo Monitoring of Energy Metabolism with Genetically Encoded Fluorescent Biosensors
All organisms fuel and build themselves through their energy metabolism. While classic biochemistry conceptualizes the fluxes of energy and matter, our understanding of how energy metabolism works in ...
annualreviews.org
The N-degron pathway regulates glucose and insulin homeostasis through the lysosomal degradation of RXRA/RXRα via SQSTM1/p62: Autophagy: www.tandfonline.com/doi/abs/10.1...
The N-degron pathway regulates glucose and insulin homeostasis through the lysosomal degradation of RXRA/RXRα via SQSTM1/p62
Central to the pathogenesis of type 2 diabetes (T2D) is the failure in insulin secretion from pancreatic β-cells associated with insulin resistance. The nuclear receptor RXRA/RXRα (retinoid X recep...
tandfonline.com
New review out on protein N-terminal formylation - a stress-inducible modification of eukaryotic proteins #N-degron @ispt-proteinterm.bsky.social www.nature.com/articles/s12...
N-terminal formylmethionine as a degron and a specific signal in proteostasis and stress adaptation - Experimental & Molecular Medicine
N-terminal methionine formylation, a protein modification once thought to be exclusive to bacteria and organelles, also occurs on proteins synthesized in the cytosol of yeast and human cells, challeng...
nature.com
An oxygen-sensing Polycomb-group protein encodes flooding stress memory in plants https://www.biorxiv.org/content/10.64898/2026.05.01.722198v1
So happy and proud to share our lab’s first #plantscience research article, revealing that angiosperms have the capacity to encode memory of flooding stress. A heroic effort by @aidamaric.bsky.social in collaboration with @djgibbs.bsky.social and others. A brief 🧵 www.biorxiv.org/content/10.6...
biorxiv.org
University of Nottingham set to cut 600 jobs in major cost-cutting move #Nottinghamshire #Notts
University plans 600 job cuts in major cost-cutting move
The university hopes the move will stop it from running out of cash
nottinghampost.com
N-terminal cysteine dependent proteolysis of RGS4/5 is not sensitive to physiological oxidative stress | Preprint by Ya-Min Tian, Haeun Kim, Peter Ratcliffe & Thomas Keeley @ox.ac.uk @ispt-proteinterm.bsky.social #N-degron #cysteine www.biorxiv.org/content/10.6...
biorxiv.org
We knew PCOs & ERFVIIs regulated plant hypoxia, but this work shows they also manage the 'reoxygenation' stress. www.nature.com/articles/s41... @biology.ox.ac.uk @ox.ac.uk @uni-muenster.de
H2O2 repurposes plant O2 sensing to regulate post-hypoxia responses - Nature
Experiments in Arabidopsis demonstrate that group VII ethylene response factors show differential responses to different stimuli, enabling plants in flood-prone environments to adapt to both submergen...
nature.com
🎉 Thrilled - our new Nature Chemistry paper identifying H3K9acOH, a new histone PTM formed by JmjC oxygenase KDM3A - revealing an O2‑dependent PTM in chromatin regulation. Congrats to CRUK KDM team in the Kawamura & Schofield groups & thanks to our amazing collaborators! 📄 rdcu.be/fdx4f #Epigenetics
Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway Lin et al. nph.onlinelibrary.wiley.com/doi/10.1111/...
The N-degron pathways move from basic to applied science. This pathway will prove to be of key importance for agricultural improvement. Very happy to have been a part of this work led by Chen Lin and colleagues. #plantscience #nendrule #hypoxia nph.onlinelibrary.wiley.com/doi/10.1111/...
Generation of Brassica napus with enhanced Sclerotinia sclerotiorum resistance through CRISPR/Cas9‐mediated inhibition of the PROTEOLYSIS6 N‐degron pathway
Click on the article title to read more.
nph.onlinelibrary.wiley.com
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
science.org
New publication from Markus Wirtz and colleagues on N-terminal protein acetylation: www.nature.com/articles/s41...
The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - Nature Communications
Protein N-terminal acetylation profoundly influences protein fate. Here, the authors establish NatB as a central regulator of the interplay between ubiquitin–proteasome system and autophagy, and highl...
nature.com
🌱 CRAG launches an international call for early‑career researchers! We invite young scientists interested in starting their independent research group at CRAG 📅 Deadline - April 26 Apply now 👉 https://f.mtr.cool/jdwzombrbd
Proteostasis UK Logo Competition Design our new logo and win registration, UK‑based travel, and accommodation to attend the UK Proteostasis Meeting 2026, 20–21 July at The Francis Crick Institute, London. See here for more information: proteostasisuk.co.uk/calls/proteo... Deadline: 1st May 2026
I am definitely where I belong! So proud of me right now 🥰 and grateful of my support system in this team 🥂!
Finally officially out!! www.pnas.org/doi/10.1073/... We moved the main oxygen sensing machinery from plants to yeast and we learned a few things!
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | PNAS
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, ...
pnas.org
What features are required to shape hypoxic niches enclosing meristems? We @viktoriiavoloboeva.bsky.social in collab @pieterverboven.bsky.social found that a combination of cuticle barrier, densely packed tissue and metabolic activity all uniquely contribute to maintain shoot apical meristem hypoxia
