🚨Excited to announce a new preprint from our lab, where we describe an ancient metabolic axis that controls mitochondrial genome copy number; a mechanism we uncovered in human cells that stretches through evolution to control mtDNA in flies, yeast and even plants!

Today in @nature.com, we describe how discarded reads in biobank-scale WGS can help resolve the genetic predictors and consequences of Epstein-Barr Virus (EBV) infection. Wonderful working with @ryandhindsa.bsky.social @sherrynyeo.bsky.social @erinmayc.bsky.social www.nature.com/articles/s41...

Population-scale sequencing resolves determinants of persistent EBV DNA - Nature

Population-scale WGS reveals genetic determinants of persistent EBV DNA, linking immune regulation—especially antigen processing and MHC class II variation—to EBV persistence and heterogeneous di...

nature.com

Really elegant work, and something tells me the answer to the mammalian question is just around the corner 👏

Stirling Churchman@stirlingchurchman.bsky.social · 8mo ago

Oxidative phosphorylation complexes contain subunits encoded by both the nuclear and mitochondrial genomes. How do cells coordinate the synthesis and assembly of these complexes at the inner membrane? We teamed up with Martin Ott (@mitolab.bsky.social) to address this in two recent papers.

Bravo 👏 @ryanlab.bsky.social - big moment for the lab and important findings re potential pathogenic mechanisms of mitochondrial disease

RyanLab_TCD@ryanlab.bsky.social · 9mo ago

Very excited to announce that the first paper from the lab is now live @natcomms.nature.com #mitochondria #immunometabolism This work was led by postdoc Eloise marques with many important contributions from all of our co-authors. Please check it out! www.nature.com/articles/s41...

And finally - if you'd like to have our recent paper on functionally dominant mutations in mtDNA explained in podcast form, please see youtu.be/TY1hxrJzq5Q?... p.s. thank you @albertosanzmon1.bsky.social :)

Mitochondrial Ribosome Mutations: A Hidden Driver in Cancer

YouTube video by The Sanz Science Experience

youtu.be

For those who’d like a high level summary of our paper today, please check out the accompanying research briefing: www.nature.com/articles/s41...

Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask? rdcu.be/eN1jm

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer

Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...

rdcu.be

I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it. The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma. tl;dr it's glam-slop & everyone involved should be embarrassed

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature

mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.

nature.com

Hugely important paper for those with an interest in how mitochondrial genetic diversity develops. Bravo 👏

Systems and Signals@syssig.bsky.social · last yr.

We're pleased our exciting paper 'Cryptic mitochondrial ageing coincides with mid-late life and is pathophysiologically informative in single cells across tissues and species' is now out in Nature Comms: www.nature.com/articles/s41...

Ya-Ting Chang, @nanigrotjahn.bsky.social et al. @scripps.edu present a membrane-guided approach for identifying a subset of cytoplasmic #ribosomes oriented for protein import on the surface of #mitochondria in budding yeast using #cryoET: rupress.org/jcb/article/...

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

A fantastic lab and environment doing exciting science - check these guys out! 👍

Puigserver Lab@ppuigserverb.bsky.social · 2y ago

We are hiring! After the publication of our last paper, our lab has openings for #postdoc fellows in projects looking at the interactions between tumor metabolism and immunology. Direct inquiries to pere_puigserver@dfci.harvard.edu. Please share! (1/2)

While this is an interesting piece - there are quite a few issues that have slipped through peer review here: e.g. controlling for heteroplasmy levels in their patient associations (the mutation calls for which are not properly provided in source data) ED Fig 9 @natureportfolio.bsky.social

Payam Gammage@mito-oncogene.bsky.social · 2y ago

It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...

It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature

Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

nature.com

www.nature.com/articles/s41... What an effort!! Great news for the mito disease community 👏👏👏

Precise modelling of mitochondrial diseases using optimized mitoBEs - Nature

A study reports optimized mitochondrial base editors with reduced off-target effects to facilitate the generation of mouse models of human mitochondrial diseases.

nature.com

Really cool work from @ppuigserverb.bsky.social lab! Further strengthening the emerging links between perturbed bioenergetics and effectiveness of immunotherapy 👌👍

Puigserver Lab@ppuigserverb.bsky.social · 2y ago

New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ

Fine-tuning tumor immunogenicity with mitochondrial complex I Our views on a very cool paper from @ppuigserverb.bsky.social we hope you like it! www.nature.com/articles/s43...

🆕Opportunity for a Computational Biologist/Bioinformatician to join @mito-oncogene.bsky.social leading on the interrogation and integration of multi-modal data arising from preclinical models and patients 📅Closing date: 7 February 2025 www.crukscotlandinstitute.ac.uk/careers/comp...

Really cool work from @ryanlab.bsky.social !! A lot to chew over here 👌👌👌

RyanLab_TCD@ryanlab.bsky.social · 2y ago

1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫 **An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo** #mitochondria #immunometabolism #macrophages 📄Read here: www.biorxiv.org/content/10.1...

Really pumped to see our paper on how mtDNA mutations modify tumour biology with @edreznik.bsky.social & colleagues highlighted by the US National Cancer Institute’s Division of Cancer Biology as one of their advances of 2024! If you’re interested do check it out 😊 www.cancer.gov/about-nci/or...

Okey dokey here goes! First real post - please reshare if appropriate 🙏 🔔We’ve got two postdoc level positions opening in our lab! One wet lab, one computational🔔 We’re a scientifically diverse, friendly bunch working at the interface of mitochondrial biology, metabolism & cancer in Glasgow, UK.

Hey #science people - new kid on the block, fresh from the other place, over here 👈 I mostly post papers on mitochondria, cancer and genome editing, with a side helping of dumb internet humour, UK political satire and occasional exasperation with #arsenalFC. TLDR; science meets dad jokes 😎