🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social‬ at our DZD-Partner #DIfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️

Maximilian Kleinert@mkleinert.bsky.social · 2y ago

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Today, we report that chronic intermittent fasting impairs beta-cell maturation and function in adolescent mice. Using scRNAseq, we delineated a "maturation score" for beta-cells. Long-term IF good if you're older, might be harmful if you are still developing! 👇 www.cell.com/cell-reports...

Our new paper from @clemmensenc.bsky.social @metabolcenter.bsky.social is available online! I briefly summarize here our findings on the effects of short-term overfeeding in mice! We show real time energy expenditure data during and after overfeeding! diabetesjournals.org/diabetes/art... 🧵 (1/n)

Time-resolved effects of short-term overfeeding on energy balance in mice

To curb the obesity epidemic, it is imperative that we improve our understanding of the mechanisms controlling fat mass and body weight regulation. While g

diabetesjournals.org

Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail physoc.onlinelibrary.wiley.com/doi/10.14814...

Skeletal muscle ribosome analysis: A comparison of common assay methods and utilization of a novel RiboAb antibody cocktail

While total RNA concentrations putatively represent ribosome content, there is a need to homologize various quantification approaches. Thus, total RNA concentrations ([RNA]) provided through UV–Vis s...

physoc.onlinelibrary.wiley.com

Shamelessly😬 reposting our recent work to a broader metabolism network—thanks to @frezzalab.bsky.social starter packs. We’d love to hear your thoughts!

Maximilian Kleinert@mkleinert.bsky.social · 2y ago

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it. go.bsky.app/7Uwa6fb

Why Is the American Diet So Deadly? A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity. @DhruvKhullar www.newyorker.com/magazine/202...

Why Is the American Diet So Deadly?

A scientist tried to discredit the theory that ultra-processed foods are killing us. Instead, he overturned his own understanding of obesity.

newyorker.com

NEW ISSUE! We start 2025 approaching gut-brain crosstalk from a variety of perspectives, including neuroendocrine regulation of gut-brain signaling, interaction between microbiome and circadian rhythms, microbial metabolites associated with gut health and the potential of microbiome-based therapies.

A really nice special issue in @jphysiol.bsky.social by Dr. Chris Sundberg “Physiology of ageing skeletal muscle and the protective effects of exercise” feat. some work by our lab and many others! Check it out @myoblue.bsky.social physoc.onlinelibrary.wiley.com/toc/14697793...

Special Issue: Physiology of ageing skeletal muscle and the protective effects of exercise: The Journal of Physiology: Vol 603, No 1

<em>The Journal of Physiology</em> publishes research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.

physoc.onlinelibrary.wiley.com

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications

Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

nature.com