Martin Lauritzen
@mlauritz.bsky.social
Professor of Translational Neurobiology at University of Copenhagen. Research interests are brain aging, blood-brain barrier, drug delivery, brain blood vessels, brain energy and metabolic water and cortical spreading depolarization.
🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧪🧵
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
A budget for brain metabolic water production by glucose catabolism during rest, rises in activity and sleep - Fluids and Barriers of the CNS
Maintaining brain fluid homeostasis is of critical importance for creating a stable environment conducive to optimal neuronal functioning, nutrient distribution, and waste product removal. In this stu...
fluidsbarrierscns.biomedcentral.com
Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
doi.org
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation alzres.biomedcentral.com/articles/10....
The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation - Alzheimer's Research & Therapy
Background Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer’s Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, t...
alzres.biomedcentral.com