Sharad Kumar
@molregulation.bsky.social
Biomedical scientist passionate about discovery research
A new perspective on Caspase-2, liver polyploidy and age-related liver cancer. www.sciexplor.com/articles/EXO...
The caspase-2 paradox in liver polyploidy and cancer risk
Caspase-2 is a key genome-surveillance protease that functions to kill or arrest cells with abnormal chromosome content, via PIDDosome-dependent and -independent mechanisms. However, this surveillance...
sciexplor.com
“HECT ubiquitin ligases as regulators of inflammatory signalling” In this timely and well-organised review, Prof. Sharad Kumar and colleagues provide insights into how ubiquitin signalling shapes inflammation and disease. ⤵️ www.nature.com/articles/s41...
nature.com
The E3-ome gene-centric compendium reveals the human E3 ligase landscape: Cell www.cell.com/cell/fulltex...
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented know...
cell.com
onlinelibrary.wiley.com/doi/full/10....
Increased Urinary Extracellular Vesicles and Reduced Expression of NEDD4L in Patients With Type 2 Diabetes and Diabetic Nephropathy
Introduction Diabetic nephropathy (DN) is a leading cause of chronic kidney disease. Current diagnosis requires the persistent presence of albuminuria and/or reduction in estimated glomerular filtra...
onlinelibrary.wiley.com
The E3-ome gene-centric compendium reveals the human E3 ligase landscape: Cell www.cell.com/cell/fulltex...
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented know...
cell.com
onlinelibrary.wiley.com/doi/full/10....
Increased Urinary Extracellular Vesicles and Reduced Expression of NEDD4L in Patients With Type 2 Diabetes and Diabetic Nephropathy
Introduction Diabetic nephropathy (DN) is a leading cause of chronic kidney disease. Current diagnosis requires the persistent presence of albuminuria and/or reduction in estimated glomerular filtra...
onlinelibrary.wiley.com
Hidden cancer risk behind fatty liver disease targets | EurekAlert! www.eurekalert.org/news-release...
Hidden cancer risk behind fatty liver disease targets
Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age.
eurekalert.org
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice | Science Advances www.science.org/doi/full/10....
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
science.org
Great to see this work, led by Loretta Dorstyn, with contributions from many colleagues and funded by NHMRC now out. Our first publication of 2026 and from the new Adelaide University. www.science.org/doi/10.1126/...
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
science.org
Great to see this work, led by Loretta Dorstyn, with contributions from many colleagues and funded by NHMRC now out. Our first publication of 2026 and from the new Adelaide University. www.science.org/doi/10.1126/...
Caspase-2 deficiency drives pathogenic liver polyploidy and increases age-associated hepatocellular carcinoma in mice
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer.
science.org
Caspase-2 inactivation promotes pathogenic hepatocyte polyploidy and age-related liver cancer www.science.org/doi/10.1126/... @molregulation.bsky.social
Of all the stupid things that this regime has done, this is right up near the top. Postdoctoral researchers come to the US on H-1B visas. This will further destroy the US science enterprise. Stupid stupid stupid.
Trump administration to add $100,000 fee for H-1B visas
The Trump administration is targeting a visa widely used by tech companies and other employers to hire foreign workers.
cbsnews.com
Very cool study: LYVAC/PDZD8 is a lysosomal vacuolator | Science www.science.org/doi/10.1126/...
LYVAC/PDZD8 is a lysosomal vacuolator
Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...
science.org
www.nature.com/articles/s41... New publication from our lab.
Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination - Cell Death Discovery
Cell Death Discovery - Phospholipid scramblase 1 (PLSCR1) is a novel substrate of NEDD4-2 (NEDD4L) mediated ubiquitination
nature.com
🧬 New paper alert! @molregulation.bsky.social’s team reveals a paradox: Nedd4-2 deficiency triggers kidney injury but protects against high blood glucose in diabetes. Fascinating twist! 🔄
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice - Cell Death & Disease
Cell Death & Disease - Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice
nature.com
New organ clock data support the anti-aging benefits of estrogen for postmenopausal women. Reviewed here in context with previous and other recent reports. erictopol.substack.com/p/new-anti-a...
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming https://go.nature.com/43lhNbO
Climate risk for younger generations is set to soar
An analysis shows that large fractions of future generations will be exposed to extreme climate events that would occur only once every 10,000 years in the absence of global warming.
go.nature.com
Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals https://go.nature.com/3EpQfIA
Tiger turnaround as populations grow in India
Nature - Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals.
go.nature.com
Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com www.nature.com/articles/s41...
Nature research paper: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia https://go.nature.com/4j2WTDZ
Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia - Nature
Explosive growth is attributed to the BCR::ABL1 gene 3–14 years before diagnosis of chronic myeloid leukaemia, highlighting the oncogenic potency of gene fusion and the slow and sequential trajectories of most other cancers.
go.nature.com
Studies of researchers globally suggest there is a mental-health crisis in academia https://go.nature.com/3RNAbmZ
A mental-health crisis plagues PhDs — these evidence-led initiatives offer help
Communities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics.
go.nature.com
“I’ve never thought that this would be accomplished in my lifetime” Researchers have successfully sequenced the complete genomes of six ape species https://go.nature.com/4j9jE9k
What makes us human? Milestone ape genomes promise clues
DNA sequences for the chimpanzee, orangutans and more will help scientists to determine what sets humans apart from other apes.
go.nature.com
Researchers have created the largest and most detailed wiring diagram of a mammalian brain to date, by mapping cells in a cubic millimetre of a mouse’s brain tissue https://go.nature.com/4cu68dN
Biggest brain map ever details huge number of neurons and their activity
3D reconstruction is the first to overlay neuronal activity on a large-scale map of brain cells.
go.nature.com
Cancer vulnerabilities exposed by finding interactions among DNA repair factors @nature.com @jcornlab.bsky.social www.nature.com/articles/s41... www.nature.com/articles/d41...
Of >105,000 participants with 30-year follow-up, only 9.3% achieved healthy aging (age 70, w/o any chronic diseases). Their diet was significantly associated with this outcome. @naturemedicine.bsky.social
Overseas universities see opportunity in U.S. ‘brain drain’ | Science | AAAS www.science.org/content/arti...
Overseas universities see opportunity in U.S. ‘brain drain’
But many U.S.-based scientists seeking to leave may struggle to find positions in countries grappling with funding issues of their own
science.org
Some scientists in the United States have told Nature that they are considering leaving the country in the wake of widespread disruption to research brought in by the Trump administration Are you thinking about leaving? https://go.nature.com/4bMGd0J
These frustrated scientists want to leave the United States – do you? Take Nature’s poll
Nature - In the wake of the Trump administration’s funding freezes and job cuts, some researchers are planning their next move.
go.nature.com
The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. www.science.org/doi/10.1126/...
Senolytic treatment for low back pain
Senolytics drugs can reduce back pain by removing senescent cells from the intervertebral discs and spinal cord.
science.org
