@juruehle.bsky.social's PhD work is now out in Genome Biology 📚🧬 : Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity link.springer.com/article/10.1186/s13059-026-04186-9 Julia achieved three cool things with this work...🧵

Lentiviral single-cell MPRA of synthetic enhancers reveals motif affinity-based encoding of cell state specificity - Genome Biology

Background Cell state-specific gene expression programs emerge from the interplay between cis-regulatory elements (CREs), such as enhancers, and transcription factors (TFs). Massively parallel reporte...

link.springer.com

We are delighted by the publication of our work identifying human LBR and LAP2 as key heterochromatin tethers at the nuclear envelope. Their loss massively changes 3D chromatin organization, and causes defects in epigenetic maintenance and cell fate determination. doi.org/10.1038/s415...

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis - Nature Cell Biology

Lewis et al. identify lamin B receptor (LBR) and lamina-associated polypeptide 2 (LAP2) as major factors that tether heterochromatin to the envelope. Deletion of these proteins causes changes in 3D ge...

doi.org

Moritz Mall, DKFZ and HITBR, has been awarded the Sibylle Assmus Foundation’s Neuro-Oncology Prize for his research on the plasticity of malignant brain tumors and how this can be used as a potential therapeutic approach. Congratulations! 👏 @moritzmall.bsky.social t1p.de/p49cb

The Plasticity of Malignant Brain Tumors as a Potential Therapeutic Approach: Sibylle Assmus Prize for Neuro-Oncology Awarded to Moritz Mall

The ability of cancer cells to change their identity makes tumors such as glioblastoma particularly aggressive and resistant to treatment. Moritz Mall, of the German Cancer Research Center (DKFZ) and ...

t1p.de

Thank you so much for the kind words! 🙏 I’m truly honored by this recognition from the Sibylle Assmus Foundation and grateful to my fantastic team at @dkfz.bsky.social, ZI Mannheim, and HITBR – this work wouldn’t be possible without them.

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · 3mo ago

Moritz Mall, DKFZ and HITBR, has been awarded the Sibylle Assmus Foundation’s Neuro-Oncology Prize for his research on the plasticity of malignant brain tumors and how this can be used as a potential therapeutic approach. Congratulations! 👏 @moritzmall.bsky.social t1p.de/p49cb

Für seine Forschung zur Plastizität bösartiger Hirntumoren und wie sich diese als möglicher Therapieansatz nutzen lässt, erhält Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, den Preis für Neuroonkologie der Sibylle Assmus Stiftung. @moritzmall.bsky.social t1p.de/wlbyt

Plastizität bösartiger Hirntumoren als möglicher Therapieansatz: Sibylle Assmus Preis für Neuroonkologie an Moritz Mall

Die Fähigkeit von Krebszellen, ihre Identität zu wechseln, macht Tumoren wie das Glioblastom besonders aggressiv und therapieresistent. Moritz Mall, Deutsches Krebsforschungszentrum (DKFZ) und Hector ...

t1p.de

Herzlichen Dank für die schönen Worte! 🙏 Ich freue mich sehr über die Auszeichnung der Sibylle Assmus Stiftung und bin meinem großartigen Team am @dkfz.bsky.social, ZI Mannheim und HITBR sehr dankbar – ohne euch wäre diese Forschung nicht möglich.

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · 3mo ago

Für seine Forschung zur Plastizität bösartiger Hirntumoren und wie sich diese als möglicher Therapieansatz nutzen lässt, erhält Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, den Preis für Neuroonkologie der Sibylle Assmus Stiftung. @moritzmall.bsky.social t1p.de/wlbyt

Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

Double ERC success for DKFZ researchers: Hellmut Augustin @hellmutaugustin.bsky.social and Michael Platten @michael-platten.bsky.social have been selected by the European Research Council @erc.europa.eu for the prestigious Proof of Concept (PoC) grants. #ERCPoC 👏 t1p.de/zau31

Double ERC success for DKFZ researchers

With its Proof of Concept (PoC) grants, the European Research Council (ERC) supports scientists in further developing the economic potential of their research results. Two scientists from the German C...

t1p.de

Researchers from DKFZ, University Hospital of Tübingen and @sbpdiscovery.bsky.social discovered that chronic cellular stress promotes liver cancer - but at the same time renders tumors vulnerable to immunotherapy. @nature.com t1p.de/1vosw

A double-edged sword: Chronic cellular stress promotes liver cancer - but at the same time renders tumors vulnerable to immunotherapy

A key molecular mechanism drives the growth of liver cell cancer while simultaneously suppressing the body's immune response to the tumor. This has now been published in the journal Nature by a team l...

t1p.de

The @dkfz.bsky.social PhD Program is open, and the Mall Lab is recruiting PhD students. 1: in vivo and organoid models to study and treat autism associated disorders. 2: cancer cell plasticity in brain tumors using single cell genomics and perturbation screens. Apply now: www.dkfz.de/en/career/in...

Werden Sie Teil unseres Teams! Become part of our team! 💡Die Health + Life Science Alliance Heidelberg Mannheim sucht ab sofort in Vollzeit: 👩🏻‍🔬Referent∗in👨‍🔬 (w/m/d) Bewerbungen als PDF-Datei bis 30.11.2025 an: andrea.leibfried@bioquant.uni-heidelberg.de adb.zuv.uni-heidelberg.de/info/INFO_FD... #job

Presenting recipients of our 2025 Stimulator Grant: 👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism. 🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social @dkfz.bsky.social

Looking forward to this collab with @moritzmall.bsky.social and Barbara Treutlein! We’ll generate high-throughput multi-modal CRISPR data on ASD risk genes in 🧠 organoids & assembloids, and build an ML model of gene regulation dynamics to analyze the data and enable future in silico experiments.

Health + Life Science Alliance Heidelberg Mannheim @hlsalliance.bsky.social · 10mo ago

Presenting recipients of our 2025 Stimulator Grant: 👉TACTICS: Thalamocortical Assembloids and Computational Tools for Investigating Cellular Signatures in #Autism. 🧠How do autism-linked mutations disrupt early brain development? @moritzmall.bsky.social @steglelab.bsky.social @dkfz.bsky.social

Since their discovery in 2004, the grid cells in the brain have been regarded as a kind of "GPS in the head." However, scientists at DKFZ and Heidelberg University Hospital have now shown that grid cells work much more flexibly than previously assumed. @nature.com Neuroscience t1p.de/hpj1m

No GPS in the head: How the brain flexibly switches between internal maps

Since their discovery in 2004, the grid cells in the brain, which are important for our orientation, have been regarded as a kind of “GPS in the head.” However, scientists at the German Cancer Researc...

t1p.de

🚨 Registration deadline for the EACR conference on #cancerneuroscience is September 15 ‼️ Please join us in beautiful Bilbao for exciting discussions on the dialogue between the nervous system and cancer 🔬🧠 See you soon!

‪GSCN 2025 Best Publication Award goes to B. Lim, @moritzmall.bsky.social, J. Zaugg, A. Kamal @biomedizin.unibas.ch for joint publication in @naturegenz.bsky.social All infos on www.gscn.org @dkfz.bsky.social @www.helmholtz-munich.de @embl.org @mdc-berlin.bsky.social @bihatcharite.bsky.social

Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏 @gscnoffice.bsky.social

🎉 Herzlichen Dank für den @gscnoffice.bsky.social-Preis „Publication of the Year 2025“ zu unserer @natgenet.nature.com Publikation: www.nature.com/articles/s41... Diese Auszeichnung ist echte Teamleistung—danke an alle Mitwirkenden. Auf zu den nächsten Schritten im Kampf gegen Krebs!

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · 12mo ago

Den GSCN 2025 Publication of the Year Award erhält @moritzmall.bsky.social zusammen mit Bryce Lim und weiteren Co-Autoren für ihre Veröffentlichung "Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis". 👏 @gscnoffice.bsky.social

🚨 @dkfz.bsky.social Postdoctoral Fellowships 2025 — Postdoc opening (Mall Lab) Work at the interface of neurodevelopment, epigenetic repression & cancer neuroscience. Apply: jobs.dkfz.de/en/jobs/1679... #Postdoc #Plasticity #Neurodegeneration #CancerNeuroscience

We're seeking a PhD student passionate about ML, biology, and driving impact in healthcare! You'll be working on multi-omics factorization models for personalized medicine, co-supervised by @junyanlu.bsky.social. 👉 Project: www.helmholtz.de/assets/hidss... ✍️ Apply: hidss4health.de/application

Application - Helmholtz Information & Data Science Academy

hidss4health.de

Hands down the best meeting this year so far! Thanks for the fantastic organization @matlupien.bsky.social @shenhui1986.bsky.social Bonus was a musical finale - who said science cannot be fun :)

Mathieu Lupien@matlupien.bsky.social · last yr.

1/ What a week! The 2025 GRC on Cancer Genetics and Epigenetics just wrapped up. I'm still energized by the phenomenal science, deep discussions, and vibrant sense of community. 🔗 www.grc.org/cancer-genet... #GRCCancerGenetics #Epigenetics

What keeps cancer cells in check—and can we tame them? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇 📍 Spatial & multi-omic atlas: www.biorxiv.org/content/10.1... 📍 Regulatory logic: www.biorxiv.org/content/10.1...

13/ Want to learn more? Read our regulatory paper www.biorxiv.org/content/10.1... and companion spatial multi-omics study www.biorxiv.org/content/10.1... Watch out for thread from @bayraktarlab.bsky.social on mapping conserved spatiotemporal trajectories of GB

Decoding Plasticity Regulators and Transition Trajectories in Glioblastoma with Single-cell Multiomics

Glioblastoma (GB) is one of the most lethal human cancers, marked by profound intratumoral heterogeneity and near-universal treatment resistance. Cellular plasticity, the capacity of cancer cells to t...

biorxiv.org

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktarlab.bsky.social @oliverstegle.bsky.social and @moritzmall.bsky.social, Preprint at end🧵👇

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Thank you, @hlsalliance.bsky.social! Your backing lets junior teams like ours pursue fundamental, high-risk research to better understand cancer. Excited to keep advancing the frontiers together with many collaborations within the Alliance.

Health + Life Science Alliance Heidelberg Mannheim @hlsalliance.bsky.social · last yr.

👏Congratulations to👏 🎉@moritzmall.bsky.social and 🏆@venkataramanilab.bsky.social at @UKHD for receiving the Hella-Bühler Price for their outstanding contributions to cancer research. www.uni-heidelberg.de/en/newsroom/... Their research groups are supported by the @hlsalliance.bsky.social.

I am very grateful to @uniheidelberg.bsky.social and the Hella Bühler Foundation for this honour. Sharing the prize with the brilliant @venkataramanilab.bsky.social and our amazing teams makes me extremely proud. I am excited to channel this prize into the next wave of cancer-fighting ideas!

Universität Heidelberg@uniheidelberg.bsky.social · last yr.

Award for Outstanding Contributions to Cancer Research: Dr Dr Varun Venkataramani and Dr Moritz Mall share the 100,000-euro Hella Bühler Prize www.uni-heidelberg.de/en/newsroom/...

Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social 👉 t1p.de/1dnqw

Vielen Dank für die große Ehrung und die starke Unterstützung durch das @dkfz.bsky.social , das Hector Institut & alle Partner! Gemeinsam treiben wir in Heidelberg die Krebsforschung voran – die spannendsten Entdeckungen kommen erst noch. 🙏🔬 #HellaBühlerPreis #TeamScience

Deutsches Krebsforschungszentrum (DKFZ)@dkfz.bsky.social · last yr.

Ausgezeichnet für herausragende #Krebsforschung: Den mit 100.000 Euro dotierten diesjährigen Hella Bühler-Preis teilen sich Moritz Mall, DKFZ und Hector Institut für Translationale Hirnforschung, und Varun Venkataramani vom Universitätsklinikum Heidelberg. 👏 @moritzmall.bsky.social 👉 t1p.de/1dnqw

Do you want to do your #postdoc in #cancerresearch with the most prestigious #fellowship in Europe? Apply to DKFZ Marie Skłodowska Curie MasterClasses by May 19. Projects in #cellandmolecularbiology #genomics #bioinformatics #immunology #medicaltechnology, #epidemiology. Apply here: t1p.de/nx6tu